iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136717.14	ENST00000376113.6	ENSP00000365281.2
ENSG00000136717.14	ENST00000357970.7	ENSP00000350654.3
ENSG00000136717.14	ENST00000393040.7	ENSP00000376760.3
ENSG00000136717.14	ENST00000348750.8	ENSP00000259237.5
ENSG00000136717.14	ENST00000259238.8	ENSP00000259238.4
ENSG00000136717.14	ENST00000346226.7	ENSP00000315411.3
ENSG00000136717.14	ENST00000393041.7	ENSP00000376761.3
ENSG00000136717.14	ENST00000351659.7	ENSP00000315388.3
ENSG00000136717.14	ENST00000352848.7	ENSP00000315284.4
ENSG00000136717.14	ENST00000316724.9	ENSP00000316779.5
ENSG00000136717.14	ENST00000409400.1	ENSP00000386797.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/SH3	SH3	17244534

Classification

Family	E-value	Score	Start	End
UBD/SH3	1.90e-25	90.2	521	592

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvk........elegkrGlfPenFvekl 62
           +++kvq+++dy+a+++deL+lk+Gdvvlvi   ++eeqdegWl+gvk        ele++rG+fPenF+e++
   Q: 521  FMFKVQAQHDYTATDTDELQLKAGDVVLVIpfqNPEEQDEGWLMGVKesdwnqhkELEKCRGVFPENFTERV 592
           799*******************************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts (SH3 domain) with HCV NS5A.

Protein Sequence
(Fasta)

MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 60
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCGCCCC GGGGCGGTGC AGCTGGAGCG TCAGGGGAGT CCCGCTCGCC GCAGCCCCAG 60
CGCCGCGCGC GCCCCTCCCT CCTCGCGGAC CTGGCGGTGC CGGCGCCCGG AGTGGCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0043--Tumor suppressor

Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003023--Amphiphysin_2
IPR004148--BAR_dom
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF14604--SH3_9

PRINTS

PR01251--AMPHIPHYSIN
PR01253--AMPHIPHYSIN2
PR00452--SH3DOMAIN

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031674--C:I band
GO:0060987--C:lipid tube
GO:0016020--C:membrane
GO:0033268--C:node of Ranvier
GO:0005635--C:nuclear envelope
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0051015--F:actin filament binding
GO:0042802--F:identical protein binding
GO:0070063--F:RNA polymerase binding
GO:0048156--F:tau protein binding
GO:0008283--P:cell proliferation
GO:0006897--P:endocytosis
GO:0060988--P:lipid tube assembly
GO:0061024--P:membrane organization
GO:0042692--P:muscle cell differentiation
GO:0051647--P:nucleus localization
GO:0006997--P:nucleus organization
GO:0043065--P:positive regulation of apoptotic process
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0071156--P:regulation of cell cycle arrest
GO:0030100--P:regulation of endocytosis
GO:0045664--P:regulation of neuron differentiation
GO:0016032--P:viral process

KEGG

hsa:274

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001292	Ailuropoda melanoleuca	85.16	8.00e-171	593.00
IUUC-Apl-003830	Anas platyrhynchos	74.45	0.00e+00	835.00
IUUC-Aca-005149	Anolis carolinensis	75.98	4.00e-172	597.00
IUUC-Ath-007087	Arabidopsis thaliana	44.44	1.10e+00	26.90
IUUC-Ame-011551	Astyanax mexicanus	49.19	7.00e-137	481.00
IUUC-Bta-013069	Bos taurus	94.07	0.00e+00	994.00
IUUC-Cja-019089	Callithrix jacchus	97.98	0.00e+00	1116.00
IUUC-Cfa-020825	Canis familiaris	79.70	6.00e-174	604.00
IUUC-Cpo-022197	Cavia porcellus	96.84	0.00e+00	1016.00
IUUC-Csa-023301	Chlorocebus sabaeus	97.20	0.00e+00	1136.00
IUUC-Dre-028384	Danio rerio	62.72	5.00e-111	394.00
IUUC-Dno-029712	Dasypus novemcinctus	94.12	0.00e+00	803.00
IUUC-Dor-030441	Dipodomys ordii	85.56	0.00e+00	681.00
IUUC-Ete-032582	Echinops telfairi	71.69	0.00e+00	677.00
IUUC-Eca-034380	Equus caballus	95.41	0.00e+00	1023.00
IUUC-Eeu-035316	Erinaceus europaeus	89.47	5.00e-147	514.00
IUUC-Fca-036228	Felis catus	82.74	2.00e-168	586.00
IUUC-Fal-037539	Ficedula albicollis	72.84	0.00e+00	857.00
IUUC-Gmo-039190	Gadus morhua	66.78	8.00e-109	387.00
IUUC-Gga-041247	Gallus gallus	76.79	7.00e-146	510.00
IUUC-Gac-042188	Gasterosteus aculeatus	50.25	1.00e-150	526.00
IUUC-Ggo-044521	Gorilla gorilla	97.63	0.00e+00	1080.00
IUUC-Itr-048478	Ictidomys tridecemlineatus	96.80	0.00e+00	716.00
IUUC-Lch-050550	Latimeria chalumnae	59.05	1.00e-130	460.00
IUUC-Mcc-055717	Macaca mulatta	94.27	0.00e+00	1077.00
IUUC-Meu-056110	Macropus eugenii	76.87	1.00e-120	426.00
IUUC-Mga-059369	Meleagris gallopavo	73.02	4.00e-159	555.00
IUUC-Mmr-061149	Microcebus murinus	96.12	0.00e+00	1069.00
IUUC-Mdo-062533	Monodelphis domestica	76.59	0.00e+00	788.00
IUUC-Mmu-063911	Mus musculus	94.27	0.00e+00	1085.00
IUUC-Mpu-066246	Mustela putorius furo	96.63	0.00e+00	1081.00
IUUC-Nle-069141	Nomascus leucogenys	91.93	0.00e+00	1027.00
IUUC-Opr-070200	Ochotona princeps	77.87	0.00e+00	837.00
IUUC-Ont-071795	Oreochromis niloticus	69.71	5.00e-106	378.00
IUUC-Ocu-074817	Oryctolagus cuniculus	81.72	0.00e+00	821.00
IUUC-Obr-076905	Oryza brachyantha	31.46	5.00e-01	30.00
IUUC-Oin-079195	Oryza indica	38.71	1.10e-01	28.90
IUUC-Ola-087308	Oryzias latipes	48.24	5.00e-143	501.00
IUUC-Oga-088872	Otolemur garnettii	86.12	6.00e-162	564.00
IUUC-Ptr-091125	Pan troglodytes	98.32	0.00e+00	1112.00
IUUC-Pan-092349	Papio anubis	99.83	0.00e+00	1140.00
IUUC-Psi-093226	Pelodiscus sinensis	75.74	0.00e+00	812.00
IUUC-Pma-094139	Petromyzon marinus	58.05	9.00e-133	467.00
IUUC-Pfo-096470	Poecilia formosa	56.87	1.00e-111	397.00
IUUC-Pab-098085	Pongo abelii	86.85	0.00e+00	930.00
IUUC-Pop-098870	Populus trichocarpa	30.26	2.00e-04	38.90
IUUC-Pca-100306	Procavia capensis	88.06	2.00e-140	493.00
IUUC-Pva-103041	Pteropus vampyrus	86.17	0.00e+00	934.00
IUUC-Rno-105645	Rattus norvegicus	93.77	0.00e+00	1078.00
IUUC-Sar-113470	Sorex araneus	76.25	1.00e-116	413.00
IUUC-Tgu-117501	Taeniopygia guttata	76.79	1.00e-145	509.00
IUUC-Tru-118163	Takifugu rubripes	51.06	1.00e-150	526.00
IUUC-Tni-120465	Tetraodon nigroviridis	51.67	6.00e-144	504.00
IUUC-Tbe-127789	Tupaia belangeri	84.97	0.00e+00	645.00
IUUC-Ttr-129084	Tursiops truncatus	98.64	1.00e-173	603.00
IUUC-Xtr-132870	Xenopus tropicalis	60.14	1.00e-165	576.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence