iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024143

Ensembl Protein ID

ENSCSAP00000008851.1

UniProt Accession

A0A0D9RJR2; A0A0D9RJR2_CHLSB

Genbank Protein ID

ENSCSAP00000008851

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AQIB01149339

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000012669.1	ENSCSAT00000010762.1	ENSCSAP00000008851.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-16	58.6	119	174

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 119  IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 174
           689************************...99*************************97 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MEWALCGDDE GAWIWKGSYD WEDQWEPVWG QETWNASIRR LPRMRLLGTG AHLPSVCCRM 60
GCMKSKFLQA GGNTFSKTET SANPHCPVYV PDPTSTIKPG PNSNNRNTPG IGEGSEDIIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTGCCCAC CACCTGCTCT GCCCCCCAAC AGCTCGACCT GTTACATTTC TGTTATCCTC 60
ATGCCATCCT CTGAATAAAC ACCCATCACG CTGGTCCTTG GTACCCATGA CAATGACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	30.62	1.00e-21	98.20
IUUC-Aml-001284	Ailuropoda melanoleuca	90.93	0.00e+00	947.00
IUUC-Apl-003285	Anas platyrhynchos	78.59	0.00e+00	806.00
IUUC-Aca-004724	Anolis carolinensis	77.80	0.00e+00	785.00
IUUC-Ame-011954	Astyanax mexicanus	75.69	0.00e+00	768.00
IUUC-Bta-013060	Bos taurus	91.68	0.00e+00	961.00
IUUC-Bdi-014122	Brachypodium distachyon	31.40	1.00e-21	98.60
IUUC-Cja-019817	Callithrix jacchus	95.65	0.00e+00	978.00
IUUC-Cfa-020511	Canis familiaris	91.88	0.00e+00	959.00
IUUC-Cpo-022538	Cavia porcellus	90.12	0.00e+00	948.00
IUUC-Dre-028157	Danio rerio	76.88	0.00e+00	794.00
IUUC-Dno-029761	Dasypus novemcinctus	89.11	0.00e+00	929.00
IUUC-Eca-034090	Equus caballus	88.71	0.00e+00	920.00
IUUC-Fca-035937	Felis catus	89.11	0.00e+00	900.00
IUUC-Fal-036624	Ficedula albicollis	77.84	0.00e+00	802.00
IUUC-Gmo-039009	Gadus morhua	72.82	0.00e+00	756.00
IUUC-Gga-040296	Gallus gallus	78.90	0.00e+00	778.00
IUUC-Gac-042362	Gasterosteus aculeatus	81.61	0.00e+00	778.00
IUUC-Ggo-044570	Gorilla gorilla	98.02	0.00e+00	1018.00
IUUC-Hsa-046378	Homo sapiens	98.02	0.00e+00	1031.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	89.96	0.00e+00	941.00
IUUC-Loc-052904	Lepisosteus oculatus	78.94	0.00e+00	822.00
IUUC-Laf-053654	Loxodonta africana	89.11	0.00e+00	931.00
IUUC-Mcc-055317	Macaca mulatta	99.40	0.00e+00	1046.00
IUUC-Mga-060194	Meleagris gallopavo	81.29	0.00e+00	765.00
IUUC-Mmr-061510	Microcebus murinus	90.10	0.00e+00	938.00
IUUC-Mdo-062035	Monodelphis domestica	82.68	0.00e+00	881.00
IUUC-Mmu-064037	Mus musculus	90.10	0.00e+00	946.00
IUUC-Mpu-066874	Mustela putorius furo	90.89	0.00e+00	950.00
IUUC-Mlu-068202	Myotis lucifugus	86.06	0.00e+00	918.00
IUUC-Nle-069222	Nomascus leucogenys	98.02	0.00e+00	1020.00
IUUC-Opr-070705	Ochotona princeps	87.15	0.00e+00	922.00
IUUC-Ont-072347	Oreochromis niloticus	82.96	0.00e+00	767.00
IUUC-Ocu-074490	Oryctolagus cuniculus	89.29	0.00e+00	929.00
IUUC-Ola-086521	Oryzias latipes	81.84	0.00e+00	777.00
IUUC-Oga-088153	Otolemur garnettii	92.09	0.00e+00	958.00
IUUC-Oar-090184	Ovis aries	91.54	0.00e+00	959.00
IUUC-Ptr-090505	Pan troglodytes	94.27	0.00e+00	967.00
IUUC-Pan-092260	Papio anubis	99.80	0.00e+00	1049.00
IUUC-Pma-094311	Petromyzon marinus	73.40	0.00e+00	735.00
IUUC-Pfo-096566	Poecilia formosa	76.13	0.00e+00	795.00
IUUC-Pab-097908	Pongo abelii	77.67	0.00e+00	763.00
IUUC-Pva-103021	Pteropus vampyrus	91.09	0.00e+00	946.00
IUUC-Rno-105309	Rattus norvegicus	90.08	0.00e+00	943.00
IUUC-Sha-107099	Sarcophilus harrisii	82.33	0.00e+00	873.00
IUUC-Tgu-116912	Taeniopygia guttata	78.39	0.00e+00	797.00
IUUC-Tru-118449	Takifugu rubripes	81.80	0.00e+00	761.00
IUUC-Tae-123706	Triticum aestivum	31.01	4.00e-22	100.00
IUUC-Tur-126022	Triticum urartu	31.01	4.00e-22	100.00
IUUC-Tbe-128144	Tupaia belangeri	86.67	0.00e+00	798.00
IUUC-Xtr-132224	Xenopus tropicalis	72.04	0.00e+00	695.00
IUUC-Xma-133902	Xiphophorus maculatus	76.04	0.00e+00	794.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence