iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000095637.21	ENST00000371227.8	ENSP00000360271.3
ENSG00000095637.21	ENST00000371249.6	ENSP00000360295.2
ENSG00000095637.21	ENST00000306402.10	ENSP00000302556.6
ENSG00000095637.21	ENST00000634504.1	ENSP00000489022.1
ENSG00000095637.21	ENST00000607232.5	ENSP00000475901.1
ENSG00000095637.21	ENST00000361941.7	ENSP00000355136.3
ENSG00000095637.21	ENST00000277982.9	ENSP00000277982.5
ENSG00000095637.21	ENST00000371245.7	ENSP00000360291.2
ENSG00000095637.21	ENST00000371241.5	ENSP00000360285.1
ENSG00000095637.21	ENST00000354106.7	ENSP00000277984.4
ENSG00000095637.21	ENST00000371239.5	ENSP00000360283.1
ENSG00000095637.21	ENST00000371228.2	ENSP00000360272.2
ENSG00000095637.21	ENST00000486141.2	ENSP00000473813.1
ENSG00000095637.21	ENST00000492542.1	ENSP00000474932.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-35	122.7	1236	1292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  q+ly+y +qnddeL+l+ Gd+v+v+  e+ d gW +g++  +++ G fP n+v+ l
   Q: 1236 FSYQALYSYIPQNDDELELRDGDIVDVM--EKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1292
           6789***********************9..999***********************986 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).

Protein Sequence
(Fasta)

MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 60
TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK GYRSVHPNLP SDKSQDSSPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCTGAGT CCCAGAAAAA CAGAGCGGGG CCAGCTGCAG CGTGTAGTGC GAGTGGGGCG 60
GACGCGCGCA GCCCGCCCGC CCGGCGACCA GCAAGGTAAG CCCGCGCTCG CCCGCCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0813--Transport

Interpro

IPR028506--CAP/ponsin
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003127--SoHo_dom

PROSITE

PS50002--SH3
PS50831--SOHO

Pfam

PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9
PF02208--Sorb

SMART

SM00326--SH3
SM00459--Sorb

Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005924--C:cell-substrate adherens junction
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0045121--C:membrane raft
GO:0016363--C:nuclear matrix
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0001725--C:stress fiber
GO:0005915--C:zonula adherens
GO:0003779--F:actin binding
GO:0008092--F:cytoskeletal protein binding
GO:0005158--F:insulin receptor binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007160--P:cell-matrix adhesion
GO:0032869--P:cellular response to insulin stimulus
GO:0048041--P:focal adhesion assembly
GO:0015758--P:glucose transport
GO:0008286--P:insulin receptor signaling pathway
GO:0006936--P:muscle contraction
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0046326--P:positive regulation of glucose import
GO:0045725--P:positive regulation of glycogen biosynthetic process
GO:0046889--P:positive regulation of lipid biosynthetic process
GO:0043149--P:stress fiber assembly

KEGG

hsa:10580

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001949	Ailuropoda melanoleuca	73.98	3.00e-158	553.00
IUUC-Apl-003936	Anas platyrhynchos	80.22	3.00e-131	463.00
IUUC-Aca-004980	Anolis carolinensis	59.51	0.00e+00	1328.00
IUUC-Ame-011333	Astyanax mexicanus	70.61	2.00e-123	436.00
IUUC-Cja-018971	Callithrix jacchus	78.68	0.00e+00	636.00
IUUC-Cfa-020494	Canis familiaris	75.51	4.00e-161	562.00
IUUC-Cpo-022521	Cavia porcellus	83.80	7.00e-170	591.00
IUUC-Csa-023708	Chlorocebus sabaeus	92.10	0.00e+00	2102.00
IUUC-Cho-024684	Choloepus hoffmanni	97.46	7.00e-141	495.00
IUUC-Cin-025776	Ciona intestinalis	40.65	1.00e-26	114.00
IUUC-Dre-027905	Danio rerio	63.95	4.00e-118	419.00
IUUC-Dno-029581	Dasypus novemcinctus	71.81	1.00e-159	558.00
IUUC-Dor-030409	Dipodomys ordii	73.13	6.00e-173	602.00
IUUC-Ete-032565	Echinops telfairi	66.44	2.00e-138	487.00
IUUC-Eca-033630	Equus caballus	76.87	3.00e-179	623.00
IUUC-Eeu-035049	Erinaceus europaeus	95.44	6.00e-139	489.00
IUUC-Fca-035419	Felis catus	74.83	8.00e-173	601.00
IUUC-Fal-037511	Ficedula albicollis	77.29	1.00e-132	468.00
IUUC-Gmo-039712	Gadus morhua	71.15	1.00e-122	434.00
IUUC-Gga-040230	Gallus gallus	74.49	2.00e-166	579.00
IUUC-Gac-042510	Gasterosteus aculeatus	46.59	0.00e+00	807.00
IUUC-Ggo-045582	Gorilla gorilla	81.18	0.00e+00	655.00
IUUC-Itr-048647	Ictidomys tridecemlineatus	97.87	0.00e+00	640.00
IUUC-Lch-050442	Latimeria chalumnae	81.09	8.00e-113	402.00
IUUC-Loc-051789	Lepisosteus oculatus	78.81	2.00e-104	374.00
IUUC-Laf-054016	Loxodonta africana	69.60	3.00e-154	540.00
IUUC-Mcc-055691	Macaca mulatta	77.32	5.00e-175	608.00
IUUC-Meu-056146	Macropus eugenii	91.43	7.00e-138	485.00
IUUC-Mga-060002	Meleagris gallopavo	76.79	7.00e-131	462.00
IUUC-Mmr-060861	Microcebus murinus	77.55	2.00e-179	623.00
IUUC-Mdo-062665	Monodelphis domestica	91.02	1.00e-137	485.00
IUUC-Mmu-063837	Mus musculus	71.30	5.00e-170	592.00
IUUC-Mpu-066180	Mustela putorius furo	74.91	0.00e+00	743.00
IUUC-Mlu-067282	Myotis lucifugus	89.65	0.00e+00	2231.00
IUUC-Nle-070028	Nomascus leucogenys	81.41	0.00e+00	659.00
IUUC-Opr-071207	Ochotona princeps	68.25	3.00e-148	520.00
IUUC-Ont-071665	Oreochromis niloticus	76.75	6.00e-96	345.00
IUUC-Oan-072726	Ornithorhynchus anatinus	90.17	8.00e-131	462.00
IUUC-Ocu-073851	Oryctolagus cuniculus	79.40	2.00e-150	527.00
IUUC-Oga-089099	Otolemur garnettii	80.49	2.00e-139	489.00
IUUC-Oar-089792	Ovis aries	75.79	2.00e-176	613.00
IUUC-Ptr-091501	Pan troglodytes	81.18	0.00e+00	656.00
IUUC-Pan-092554	Papio anubis	80.95	0.00e+00	657.00
IUUC-Psi-093452	Pelodiscus sinensis	65.90	0.00e+00	1531.00
IUUC-Pma-094471	Petromyzon marinus	54.64	5.00e-70	259.00
IUUC-Pfo-097237	Poecilia formosa	58.02	3.00e-142	499.00
IUUC-Pab-097775	Pongo abelii	80.95	0.00e+00	659.00
IUUC-Pca-100184	Procavia capensis	78.81	2.00e-105	377.00
IUUC-Pva-102955	Pteropus vampyrus	72.03	1.00e-168	587.00
IUUC-Rno-105517	Rattus norvegicus	88.17	0.00e+00	2175.00
IUUC-Sha-107626	Sarcophilus harrisii	62.58	4.00e-139	489.00
IUUC-Sar-112921	Sorex araneus	71.21	6.00e-161	562.00
IUUC-Ssc-115959	Sus scrofa	87.35	0.00e+00	2105.00
IUUC-Tgu-117150	Taeniopygia guttata	77.78	6.00e-167	581.00
IUUC-Tru-118694	Takifugu rubripes	72.20	2.00e-122	433.00
IUUC-Tni-119903	Tetraodon nigroviridis	67.17	2.00e-120	425.00
IUUC-Tbe-127652	Tupaia belangeri	75.06	4.00e-159	556.00
IUUC-Ttr-129216	Tursiops truncatus	70.52	5.00e-160	558.00
IUUC-Xtr-131780	Xenopus tropicalis	56.53	0.00e+00	1185.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence