iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041707

UUCD1 version

UUC-GaA-00377

Ensembl Protein ID

ENSGACP00000010495.1

UniProt Accession

G3NYS4; G3NYS4_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000007912.1	ENSGACT00000010517.1	ENSGACP00000010495.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-126	422.2	393	728

Active Site

Position(s)	Description	Evidence
697	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 393  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRVMGLAVFHGHYING 480
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle++dpel+ksl +i+en   di+   ld tf+v+++ +g+ +++eLkp+G+n pVt+eNk+eYv+l+v+
   Q: 481  SFTLPFYKQLLGKPIQLNDLETTDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGKFSQHELKPNGRNLPVTEENKKEYVRLYVN 565
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gf+e+ip++ll+ F+++elel+i G  +id+ d+k +t+ k+ +t++s++++wFw+++e+fs+e r ++LqFv
   Q: 566  WRFMRGIEAQFLALQKGFSELIPQHLLKPFDHKELELIIGGLGKIDLADWKTNTRLKH-CTSESNVVRWFWQAVEAFSEERRGRLLQFV 653
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 654  TGSTRVPLQGFKALQgstgsagPRLFTIHLiDANTDNLPKAHTCFNRIDVPPYESYEKLYEKLLTAVEETCGFAV 728
           ******************************99999**************************************76 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISI WNHKKIHKRQ GAGFLGCIRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGACTTTG CGATGAAATA ATACCTTTTT ACCTGTGAGG AAAACCAAAA CAAGCCGCAT 60
GTTTTTAAAC GGAAGTTATT CGCGTTCCCA TTAAGTGGTG AAACGGTGTT TTGGGGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	79.87	0.00e+00	1219.00
IUUC-Apl-004155	Anas platyrhynchos	81.75	0.00e+00	1269.00
IUUC-Aca-005238	Anolis carolinensis	84.08	0.00e+00	1268.00
IUUC-Ame-010901	Astyanax mexicanus	89.57	0.00e+00	1362.00
IUUC-Bta-013221	Bos taurus	78.08	0.00e+00	1180.00
IUUC-Cja-018985	Callithrix jacchus	82.90	0.00e+00	1291.00
IUUC-Cfa-020568	Canis familiaris	80.60	0.00e+00	1242.00
IUUC-Cpo-022531	Cavia porcellus	82.64	0.00e+00	1288.00
IUUC-Csa-024145	Chlorocebus sabaeus	85.41	0.00e+00	1297.00
IUUC-Cho-024963	Choloepus hoffmanni	66.56	0.00e+00	776.00
IUUC-Dre-028341	Danio rerio	89.43	0.00e+00	1364.00
IUUC-Dno-029705	Dasypus novemcinctus	80.66	0.00e+00	1226.00
IUUC-Dme-031740	Drosophila melanogaster	71.54	2.00e-174	606.00
IUUC-Eca-034125	Equus caballus	81.95	0.00e+00	1249.00
IUUC-Fca-035905	Felis catus	83.77	0.00e+00	1249.00
IUUC-Fal-037336	Ficedula albicollis	84.49	0.00e+00	1251.00
IUUC-Gmo-039486	Gadus morhua	86.87	0.00e+00	920.00
IUUC-Gga-040218	Gallus gallus	84.63	0.00e+00	1309.00
IUUC-Ggo-045408	Gorilla gorilla	77.67	0.00e+00	1159.00
IUUC-Hsa-045878	Homo sapiens	82.90	0.00e+00	1292.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	82.46	0.00e+00	1254.00
IUUC-Loc-052628	Lepisosteus oculatus	82.37	0.00e+00	1318.00
IUUC-Laf-053644	Loxodonta africana	80.19	0.00e+00	1201.00
IUUC-Mcc-055479	Macaca mulatta	78.24	0.00e+00	1150.00
IUUC-Mga-059723	Meleagris gallopavo	81.59	0.00e+00	1238.00
IUUC-Mdo-063005	Monodelphis domestica	85.50	0.00e+00	1311.00
IUUC-Mmu-063634	Mus musculus	85.12	0.00e+00	1283.00
IUUC-Mpu-065898	Mustela putorius furo	84.18	0.00e+00	1254.00
IUUC-Mlu-067584	Myotis lucifugus	81.59	0.00e+00	1253.00
IUUC-Nle-069033	Nomascus leucogenys	82.49	0.00e+00	1256.00
IUUC-Ont-072265	Oreochromis niloticus	92.89	0.00e+00	1425.00
IUUC-Oan-073621	Ornithorhynchus anatinus	79.87	0.00e+00	1258.00
IUUC-Ocu-073960	Oryctolagus cuniculus	81.33	0.00e+00	1225.00
IUUC-Ola-086960	Oryzias latipes	85.24	0.00e+00	1245.00
IUUC-Oga-088579	Otolemur garnettii	82.90	0.00e+00	1292.00
IUUC-Oar-090396	Ovis aries	81.36	0.00e+00	1206.00
IUUC-Ptr-091624	Pan troglodytes	82.90	0.00e+00	1292.00
IUUC-Pan-092479	Papio anubis	82.49	0.00e+00	1257.00
IUUC-Pfo-097203	Poecilia formosa	95.89	0.00e+00	1417.00
IUUC-Pab-097540	Pongo abelii	82.40	0.00e+00	1222.00
IUUC-Rno-105396	Rattus norvegicus	85.12	0.00e+00	1284.00
IUUC-Sha-107216	Sarcophilus harrisii	81.82	0.00e+00	1273.00
IUUC-Ssc-116413	Sus scrofa	83.33	0.00e+00	1238.00
IUUC-Tgu-116723	Taeniopygia guttata	82.06	0.00e+00	1244.00
IUUC-Tru-117843	Takifugu rubripes	91.30	0.00e+00	1392.00
IUUC-Tsy-119455	Tarsius syrichta	81.68	0.00e+00	1165.00
IUUC-Tni-120037	Tetraodon nigroviridis	91.04	0.00e+00	1329.00
IUUC-Tbe-127879	Tupaia belangeri	69.19	0.00e+00	996.00
IUUC-Ttr-128423	Tursiops truncatus	81.26	0.00e+00	1183.00
IUUC-Xtr-132237	Xenopus tropicalis	80.87	0.00e+00	1265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence