iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092814

Ensembl Protein ID

ENSPANP00000015298.1

UniProt Accession

A0A096NQJ4; A0A096NQJ4_PAPAN

Genbank Protein ID

ENSPANP00000015298

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AHZZ01003198

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000023569.1	ENSPANT00000018805.1	ENSPANP00000015298.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-127	424.3	533	864

Active Site

Position(s)	Description	Evidence
833	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 533  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 620
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle+vdpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 621  GFTLPFYKRMLNKRPTLKDLESVDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 706
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r + +   
   Q: 707  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIR-CSLS 793
           ********************************************************99.***********************99.899* PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            g  rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 794  PGHARLPIGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 864
           *********************************************************************96 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLA SETKKTAKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCACTGC ACTCCAGCCT GGGCAGCAGA GCAAGACCCT GTCTCAAAAA GAAAAAAAGA 60
AGTATGTTAA AGGTAAGACT TTGTATCAGT TTCATGCATT CTCCTTCTGC CTTCTCTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	92.11	0.00e+00	1553.00
IUUC-Apl-003912	Anas platyrhynchos	73.02	0.00e+00	1150.00
IUUC-Aca-004291	Anolis carolinensis	78.33	0.00e+00	1365.00
IUUC-Bta-013231	Bos taurus	91.28	0.00e+00	1510.00
IUUC-Cja-019455	Callithrix jacchus	94.04	0.00e+00	1624.00
IUUC-Cfa-021017	Canis familiaris	92.55	0.00e+00	1540.00
IUUC-Cpo-021988	Cavia porcellus	91.86	0.00e+00	1579.00
IUUC-Csa-023549	Chlorocebus sabaeus	95.64	0.00e+00	1657.00
IUUC-Dre-028513	Danio rerio	90.19	0.00e+00	1110.00
IUUC-Dno-028976	Dasypus novemcinctus	91.75	0.00e+00	1580.00
IUUC-Dor-030176	Dipodomys ordii	88.56	0.00e+00	1417.00
IUUC-Eca-033949	Equus caballus	92.32	0.00e+00	1561.00
IUUC-Eeu-034529	Erinaceus europaeus	87.45	0.00e+00	1362.00
IUUC-Fca-036236	Felis catus	92.09	0.00e+00	1590.00
IUUC-Fal-036948	Ficedula albicollis	75.87	0.00e+00	1255.00
IUUC-Gmo-038842	Gadus morhua	87.48	0.00e+00	1043.00
IUUC-Gga-040617	Gallus gallus	76.77	0.00e+00	1348.00
IUUC-Gac-041338	Gasterosteus aculeatus	66.81	0.00e+00	1164.00
IUUC-Ggo-045278	Gorilla gorilla	94.84	0.00e+00	1644.00
IUUC-Hsa-046148	Homo sapiens	94.84	0.00e+00	1644.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	96.07	0.00e+00	1094.00
IUUC-Lch-050663	Latimeria chalumnae	75.23	0.00e+00	1310.00
IUUC-Loc-052604	Lepisosteus oculatus	71.66	0.00e+00	1239.00
IUUC-Laf-053944	Loxodonta africana	91.97	0.00e+00	1579.00
IUUC-Mcc-055655	Macaca mulatta	95.87	0.00e+00	1660.00
IUUC-Meu-055953	Macropus eugenii	75.97	0.00e+00	1288.00
IUUC-Mga-060190	Meleagris gallopavo	77.50	0.00e+00	1346.00
IUUC-Mmr-060896	Microcebus murinus	93.08	0.00e+00	1558.00
IUUC-Mdo-062536	Monodelphis domestica	86.96	0.00e+00	1512.00
IUUC-Mmu-064017	Mus musculus	92.09	0.00e+00	1567.00
IUUC-Mpu-066608	Mustela putorius furo	90.62	0.00e+00	1516.00
IUUC-Mlu-067623	Myotis lucifugus	88.99	0.00e+00	1508.00
IUUC-Nle-069496	Nomascus leucogenys	92.55	0.00e+00	1589.00
IUUC-Opr-071054	Ochotona princeps	83.16	0.00e+00	1397.00
IUUC-Ont-071279	Oreochromis niloticus	70.59	0.00e+00	1208.00
IUUC-Oan-073512	Ornithorhynchus anatinus	84.49	0.00e+00	1405.00
IUUC-Ocu-074271	Oryctolagus cuniculus	91.27	0.00e+00	1532.00
IUUC-Ola-087237	Oryzias latipes	65.03	0.00e+00	1107.00
IUUC-Oga-088164	Otolemur garnettii	92.89	0.00e+00	1597.00
IUUC-Oar-089698	Ovis aries	91.63	0.00e+00	1521.00
IUUC-Ptr-091306	Pan troglodytes	93.58	0.00e+00	1612.00
IUUC-Pfo-096709	Poecilia formosa	88.64	0.00e+00	1057.00
IUUC-Pab-098494	Pongo abelii	88.93	0.00e+00	1545.00
IUUC-Pca-100596	Procavia capensis	79.72	0.00e+00	1287.00
IUUC-Pva-103154	Pteropus vampyrus	87.66	0.00e+00	1494.00
IUUC-Rno-104954	Rattus norvegicus	90.91	0.00e+00	1327.00
IUUC-Sha-106781	Sarcophilus harrisii	87.19	0.00e+00	1555.00
IUUC-Ssc-116307	Sus scrofa	80.69	0.00e+00	1370.00
IUUC-Tgu-116530	Taeniopygia guttata	79.86	0.00e+00	1119.00
IUUC-Tru-118287	Takifugu rubripes	87.87	0.00e+00	1041.00
IUUC-Tsy-119097	Tarsius syrichta	80.72	0.00e+00	1173.00
IUUC-Tni-120801	Tetraodon nigroviridis	75.14	0.00e+00	1053.00
IUUC-Tbe-127793	Tupaia belangeri	83.45	0.00e+00	1414.00
IUUC-Ttr-128275	Tursiops truncatus	87.27	0.00e+00	1456.00
IUUC-Xtr-132866	Xenopus tropicalis	80.70	0.00e+00	1103.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence