iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015494.1	ENSSHAT00000018399.1	ENSSHAP00000018249.1
ENSSHAG00000015494.1	ENSSHAT00000018400.1	ENSSHAP00000018250.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-135	452.6	538	870

Active Site

Position(s)	Description	Evidence
839	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 538  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 625
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 626  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 711
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s+ iqwFw+v++e+++e+r ++LqFv
   Q: 712  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMADWQKNTIYRH-YTKNSRPIQWFWQVVKEMDNEKRIRLLQFV 799
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 800  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 870
           *********************************************************************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MASASSSRAG VGLPFEKSQL TLKVVSAKPK VHSRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGCATAAA AGGGAGCTGG AAAAAGTTCA TAAGGAAACG CAGACAATTG TCAACCTCAA 60
AAAGAAATGG ATTTCTGAGG ATTTAGAAAA CAATCAAATT TTTTATGTTG TATTTTGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

shr:100917130

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	90.96	0.00e+00	1551.00
IUUC-Apl-003912	Anas platyrhynchos	76.74	0.00e+00	1241.00
IUUC-Aca-004291	Anolis carolinensis	81.38	0.00e+00	1434.00
IUUC-Bta-013231	Bos taurus	90.94	0.00e+00	1534.00
IUUC-Cel-018299	Caenorhabditis elegans	67.18	0.00e+00	828.00
IUUC-Cja-019455	Callithrix jacchus	90.94	0.00e+00	1601.00
IUUC-Cfa-021017	Canis familiaris	91.97	0.00e+00	1559.00
IUUC-Cpo-021988	Cavia porcellus	91.17	0.00e+00	1594.00
IUUC-Csa-023549	Chlorocebus sabaeus	91.06	0.00e+00	1607.00
IUUC-Dre-028513	Danio rerio	91.59	0.00e+00	1135.00
IUUC-Dno-028976	Dasypus novemcinctus	91.52	0.00e+00	1604.00
IUUC-Dor-030176	Dipodomys ordii	89.27	0.00e+00	1468.00
IUUC-Eca-033949	Equus caballus	91.63	0.00e+00	1579.00
IUUC-Eeu-034529	Erinaceus europaeus	83.78	0.00e+00	1308.00
IUUC-Fca-036236	Felis catus	91.17	0.00e+00	1590.00
IUUC-Fal-036948	Ficedula albicollis	78.99	0.00e+00	1343.00
IUUC-Gmo-038842	Gadus morhua	89.24	0.00e+00	1070.00
IUUC-Gga-040617	Gallus gallus	80.02	0.00e+00	1442.00
IUUC-Gac-041338	Gasterosteus aculeatus	70.03	0.00e+00	1264.00
IUUC-Ggo-045278	Gorilla gorilla	91.51	0.00e+00	1619.00
IUUC-Hsa-046148	Homo sapiens	91.40	0.00e+00	1618.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	96.64	0.00e+00	1100.00
IUUC-Lch-050663	Latimeria chalumnae	78.62	0.00e+00	1394.00
IUUC-Loc-052604	Lepisosteus oculatus	75.80	0.00e+00	1321.00
IUUC-Laf-053944	Loxodonta africana	91.28	0.00e+00	1583.00
IUUC-Mcc-055655	Macaca mulatta	90.94	0.00e+00	1608.00
IUUC-Meu-055953	Macropus eugenii	84.52	0.00e+00	1462.00
IUUC-Mga-060190	Meleagris gallopavo	79.69	0.00e+00	1441.00
IUUC-Mmr-060896	Microcebus murinus	91.58	0.00e+00	1579.00
IUUC-Mdo-062536	Monodelphis domestica	96.67	0.00e+00	1695.00
IUUC-Mmu-064017	Mus musculus	90.37	0.00e+00	1588.00
IUUC-Mpu-066608	Mustela putorius furo	88.90	0.00e+00	1508.00
IUUC-Mlu-067623	Myotis lucifugus	89.12	0.00e+00	1528.00
IUUC-Nle-069496	Nomascus leucogenys	89.23	0.00e+00	1565.00
IUUC-Opr-071054	Ochotona princeps	81.65	0.00e+00	1376.00
IUUC-Ont-071279	Oreochromis niloticus	73.52	0.00e+00	1279.00
IUUC-Oan-073512	Ornithorhynchus anatinus	89.46	0.00e+00	1513.00
IUUC-Ocu-074271	Oryctolagus cuniculus	90.92	0.00e+00	1560.00
IUUC-Ola-087237	Oryzias latipes	69.64	0.00e+00	1233.00
IUUC-Oga-088164	Otolemur garnettii	91.40	0.00e+00	1609.00
IUUC-Oar-089698	Ovis aries	91.28	0.00e+00	1543.00
IUUC-Ptr-091306	Pan troglodytes	90.14	0.00e+00	1588.00
IUUC-Pan-092814	Papio anubis	87.07	0.00e+00	1519.00
IUUC-Pfo-096709	Poecilia formosa	72.78	0.00e+00	1278.00
IUUC-Pab-098494	Pongo abelii	88.46	0.00e+00	1544.00
IUUC-Pca-100596	Procavia capensis	80.78	0.00e+00	1320.00
IUUC-Pva-103154	Pteropus vampyrus	86.95	0.00e+00	1490.00
IUUC-Rno-104954	Rattus norvegicus	89.59	0.00e+00	1338.00
IUUC-Ssc-116307	Sus scrofa	77.59	0.00e+00	1357.00
IUUC-Tgu-116530	Taeniopygia guttata	75.77	0.00e+00	1200.00
IUUC-Tru-118287	Takifugu rubripes	89.81	0.00e+00	1074.00
IUUC-Tsy-119097	Tarsius syrichta	78.29	0.00e+00	1157.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.79	0.00e+00	1207.00
IUUC-Tbe-127793	Tupaia belangeri	80.05	0.00e+00	1377.00
IUUC-Ttr-128275	Tursiops truncatus	87.03	0.00e+00	1498.00
IUUC-Uma-129332	Ustilago maydis	46.21	4.00e-142	498.00
IUUC-Xtr-132866	Xenopus tropicalis	82.95	0.00e+00	1144.00
IUUC-Xma-133757	Xiphophorus maculatus	72.11	0.00e+00	1282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence