iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000087589.16	ENST00000360314.7	ENSP00000353462.3
ENSG00000087589.16	ENST00000434344.2	ENSP00000410027.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-10	41.3	16	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
            ++lyd  +  +deL + +Gd+++++ ++  ++egW+k+   l+g++Gl P+n
   Q: 16   ARALYDNCPDCSDELAFSRGDILTILeQHVPESEGWWKC--LLHGRQGLAPAN 66
           579***********************5566799******..9*********99 PP

Organism

Homo sapiens

Functional Description
(View)

Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.

Protein Sequence
(Fasta)

MKGTGIMDCA PKALLARALY DNCPDCSDEL AFSRGDILTI LEQHVPESEG WWKCLLHGRQ 60
GLAPANRLQI LTEVAADRPC PPFLRGLEEA PASSEETYQV PTLPRPPTPG PVYEQMRSWA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAGTGGT GTTTTTTTCT TCTTCTTCTT CTTTTGTGGT TTCACATAGC AAATGAGTGA 60
CAGTCTCTAC TTACAGACAA AGTGAGACGT CAGGCATTGA GACGTGAGTG TGGCTTGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR015224--Talin_cent

PROSITE

PS50002--SH3

Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF14604--SH3_9

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0007155--P:cell adhesion

KEGG

hsa:57091

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013513	Bos taurus	66.67	4.00e-78	286.00
IUUC-Cja-018847	Callithrix jacchus	87.89	7.00e-105	375.00
IUUC-Dno-029953	Dasypus novemcinctus	68.97	4.00e-70	259.00
IUUC-Gac-041754	Gasterosteus aculeatus	51.26	4.00e-26	113.00
IUUC-Itr-049018	Ictidomys tridecemlineatus	75.98	5.00e-78	285.00
IUUC-Mcc-054708	Macaca mulatta	94.27	0.00e+00	628.00
IUUC-Meu-056005	Macropus eugenii	46.26	1.00e-42	168.00
IUUC-Mmr-061129	Microcebus murinus	79.09	1.00e-98	353.00
IUUC-Mdo-062756	Monodelphis domestica	53.85	4.00e-54	206.00
IUUC-Mmu-063574	Mus musculus	69.77	5.00e-83	302.00
IUUC-Oan-073556	Ornithorhynchus anatinus	55.92	1.00e-59	224.00
IUUC-Ocu-074645	Oryctolagus cuniculus	74.22	3.00e-87	316.00
IUUC-Pfo-097206	Poecilia formosa	54.33	5.00e-29	123.00
IUUC-Rno-105677	Rattus norvegicus	70.97	2.00e-86	313.00
IUUC-Ssc-115527	Sus scrofa	76.88	1.00e-145	509.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence