iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004201

Ensembl Protein ID

ENSAPLP00000010171.1

UniProt Accession

U3ISE8; U3ISE8_ANAPL

Genbank Protein ID

ENSAPLP00000010171

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

ADON01105530

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000010387.1	ENSAPLT00000010879.1	ENSAPLP00000010171.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-62	204.6	654	691
UBD/Beta-Prp	1.70e-94	316.1	610	838

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           H+d++ c+af  +d++++++s D+++k+W+ rtg++ +
   Q: 654  HEDEILCCAFsaDDKYVATCSADKKVKIWNSRTGKCMH 691
           ***********777*********************976 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghd 137
             h+++v+  +fs+d++ +++++ D+t++v+  ++g+++  +++hed++l+++fs++++++++ s+d+ +++w+ +tg+c++ ++++h+
   Q: 610  RPHKDAVYHACFSQDRQRIASCGADKTLQVFKTESGEMLLEITAHEDEILCCAFSADDKYVATCSADKKVKIWNSRTGKCMH-IFEEHT 697
           4588888888888888888888888888888888888888888888888888888888888888888888888888888888.888888 PP
   S: 138  gvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec.......... 214
           + vnc +++  +   ll+++s+D++++lWdlk + +  t+ g h +sv++  f++n ++++s+s+dgtvklw+ ++ +           
   Q: 698  EQVNCCQFNNRSgqYLLATCSNDTFIKLWDLKGKYCRNTMFG-HVNSVNHCRFSPNDEYVASCSTDGTVKLWEARSANElktieikdff 785
           888888888877745678888888888888888888888877.8888888888888888888888888888888844442344545555 PP
   S: 215  ..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
              +++ + +  vk+   s+n++ ++ +++ + + + d++++dll+++  +++s
   Q: 786  qnADEQDDVEVLVKCCSWSRNSDMILAVAKNKLLLF-DVKTSDLLTQVIVSHHS 838
           555556666688888888888888888887666665.88888888777666655 PP

Organism

Anas platyrhynchos

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

NMDVKSRNYL LMNRQALERD IKTCYIMDHM ISDEVLTTEE EEKVKQQNTQ KERAAMLINI 60
ILTKDNNSYR SFYNALLHEG YRDLAALLQD GIPVFSGNGK SSVDGMTSYV KTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACATGGATG TGAAGAGTAG AAATTATTTA CTTATGAATC GTCAAGCTCT GGAGAGAGAC 60
ATCAAGACCT GTTATATTAT GGATCATATG ATATCTGACG AAGTACTAAC AACAGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	71.21	0.00e+00	1842.00
IUUC-Aca-004638	Anolis carolinensis	71.12	0.00e+00	1887.00
IUUC-Ani-009285	Aspergillus nidulans	25.41	4.00e-64	240.00
IUUC-Ang-009637	Aspergillus niger	23.25	9.00e-32	132.00
IUUC-Ame-011062	Astyanax mexicanus	54.32	0.00e+00	1385.00
IUUC-Bta-012865	Bos taurus	70.98	0.00e+00	1876.00
IUUC-Cel-018376	Caenorhabditis elegans	21.78	6.00e-30	126.00
IUUC-Cja-018815	Callithrix jacchus	65.74	0.00e+00	1677.00
IUUC-Cfa-020222	Canis familiaris	67.41	0.00e+00	1706.00
IUUC-Cpo-021524	Cavia porcellus	69.86	0.00e+00	1843.00
IUUC-Csa-023861	Chlorocebus sabaeus	70.90	0.00e+00	1852.00
IUUC-Cho-024484	Choloepus hoffmanni	59.52	0.00e+00	906.00
IUUC-Dre-028006	Danio rerio	53.59	0.00e+00	1293.00
IUUC-Dno-029591	Dasypus novemcinctus	71.68	0.00e+00	1886.00
IUUC-Dor-030237	Dipodomys ordii	57.26	0.00e+00	813.00
IUUC-Ete-032620	Echinops telfairi	67.58	0.00e+00	867.00
IUUC-Eca-033569	Equus caballus	71.06	0.00e+00	1842.00
IUUC-Eeu-035354	Erinaceus europaeus	50.52	1.00e-135	477.00
IUUC-Fca-036337	Felis catus	70.45	0.00e+00	1863.00
IUUC-Fal-037077	Ficedula albicollis	89.52	0.00e+00	2305.00
IUUC-Gmo-039687	Gadus morhua	49.32	0.00e+00	918.00
IUUC-Ggr-039828	Gaeumannomyces graminis	22.83	1.00e-35	145.00
IUUC-Gga-040299	Gallus gallus	90.07	0.00e+00	2353.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.18	0.00e+00	1286.00
IUUC-Ggo-045563	Gorilla gorilla	70.90	0.00e+00	1855.00
IUUC-Hsa-046771	Homo sapiens	70.90	0.00e+00	1855.00
IUUC-Lch-050200	Latimeria chalumnae	65.42	0.00e+00	1648.00
IUUC-Loc-052090	Lepisosteus oculatus	59.38	0.00e+00	1539.00
IUUC-Laf-053861	Loxodonta africana	70.53	0.00e+00	1841.00
IUUC-Mcc-055543	Macaca mulatta	70.82	0.00e+00	1847.00
IUUC-Meu-056688	Macropus eugenii	69.52	0.00e+00	1796.00
IUUC-Mga-059243	Meleagris gallopavo	90.79	0.00e+00	2367.00
IUUC-Mmr-061134	Microcebus murinus	67.11	0.00e+00	1574.00
IUUC-Mdo-062913	Monodelphis domestica	68.96	0.00e+00	1803.00
IUUC-Mmu-063811	Mus musculus	69.94	0.00e+00	1842.00
IUUC-Mpu-066780	Mustela putorius furo	70.69	0.00e+00	1819.00
IUUC-Mlu-067276	Myotis lucifugus	70.93	0.00e+00	1861.00
IUUC-Nle-069129	Nomascus leucogenys	70.42	0.00e+00	1841.00
IUUC-Opr-071007	Ochotona princeps	52.34	0.00e+00	850.00
IUUC-Ont-071348	Oreochromis niloticus	55.06	0.00e+00	1417.00
IUUC-Oan-072717	Ornithorhynchus anatinus	73.44	0.00e+00	1928.00
IUUC-Ocu-074286	Oryctolagus cuniculus	70.05	0.00e+00	1556.00
IUUC-Ola-086895	Oryzias latipes	50.12	0.00e+00	1209.00
IUUC-Oga-088678	Otolemur garnettii	70.10	0.00e+00	1831.00
IUUC-Oar-089359	Ovis aries	70.26	0.00e+00	1856.00
IUUC-Ptr-091062	Pan troglodytes	70.82	0.00e+00	1855.00
IUUC-Pan-092528	Papio anubis	75.52	0.00e+00	1143.00
IUUC-Psi-093430	Pelodiscus sinensis	79.31	0.00e+00	2051.00
IUUC-Pma-094690	Petromyzon marinus	36.55	3.00e-143	501.00
IUUC-Pfo-097204	Poecilia formosa	54.42	0.00e+00	1390.00
IUUC-Pab-097690	Pongo abelii	70.98	0.00e+00	1855.00
IUUC-Pca-100778	Procavia capensis	55.14	0.00e+00	912.00
IUUC-Pva-102870	Pteropus vampyrus	68.54	0.00e+00	1654.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	27.53	7.00e-61	229.00
IUUC-Rno-104889	Rattus norvegicus	70.02	0.00e+00	1810.00
IUUC-Sha-107465	Sarcophilus harrisii	69.75	0.00e+00	1848.00
IUUC-Sar-113268	Sorex araneus	67.52	5.00e-143	502.00
IUUC-Ssc-115654	Sus scrofa	70.10	0.00e+00	1849.00
IUUC-Tgu-117302	Taeniopygia guttata	90.54	0.00e+00	2331.00
IUUC-Tru-118363	Takifugu rubripes	54.58	0.00e+00	1393.00
IUUC-Tsy-119007	Tarsius syrichta	68.90	0.00e+00	1781.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.34	0.00e+00	1329.00
IUUC-Tbe-127413	Tupaia belangeri	60.66	0.00e+00	1105.00
IUUC-Ttr-129213	Tursiops truncatus	65.31	0.00e+00	1676.00
IUUC-Vpa-130146	Vicugna pacos	65.56	0.00e+00	1257.00
IUUC-Xtr-132559	Xenopus tropicalis	60.26	0.00e+00	1566.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence