iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044805

Ensembl Protein ID

ENSGGOP00000014405.2

UniProt Accession

G3RFN5; G3RFN5_GORGO

Protein Name

Uncharacterized protein

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014764.2	ENSGGOT00000014817.2	ENSGGOP00000014405.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-45	152.1	198	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 198  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 257
           689**************************************.7**************9886 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

KMTEEVIVIA KWDYTAQQDQ ELDIKKNERL WLLDDSKTWW RVRNAANRTG YVPSNYVERK 60
NSLKKGSLVK NLKDTLGLGK TRRKTSARDA SPTPSTDAEY PANGSGADRI YDLNIPAFVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATTTCATG TGTTCCTTGT ATACAAGCGA CGTCCCAGAT TATAATTCTC TGCTGAGATT 60
TGAGTTGGAT TTGAGAATTT GGAGAATCCC TGCAGCTGTG TAACTTCAGA GGTGTAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	97.63	0.00e+00	753.00
IUUC-Apl-003456	Anas platyrhynchos	92.91	0.00e+00	729.00
IUUC-Aca-005105	Anolis carolinensis	92.11	0.00e+00	723.00
IUUC-Ame-010966	Astyanax mexicanus	78.91	3.00e-177	614.00
IUUC-Bta-012424	Bos taurus	88.95	0.00e+00	653.00
IUUC-Cel-018144	Caenorhabditis elegans	42.40	6.00e-77	281.00
IUUC-Cja-019898	Callithrix jacchus	99.74	0.00e+00	764.00
IUUC-Cfa-020830	Canis familiaris	97.63	0.00e+00	752.00
IUUC-Cpo-021487	Cavia porcellus	88.95	0.00e+00	661.00
IUUC-Csa-023693	Chlorocebus sabaeus	99.74	0.00e+00	765.00
IUUC-Cin-025348	Ciona intestinalis	37.53	7.00e-67	247.00
IUUC-Dre-028334	Danio rerio	81.46	3.00e-180	624.00
IUUC-Dno-028973	Dasypus novemcinctus	94.74	0.00e+00	737.00
IUUC-Dor-031003	Dipodomys ordii	96.32	0.00e+00	711.00
IUUC-Ete-032792	Echinops telfairi	86.20	0.00e+00	662.00
IUUC-Eca-033656	Equus caballus	98.42	0.00e+00	758.00
IUUC-Fca-036347	Felis catus	97.89	0.00e+00	754.00
IUUC-Fal-037095	Ficedula albicollis	92.91	0.00e+00	731.00
IUUC-Gmo-039410	Gadus morhua	71.43	2.00e-162	564.00
IUUC-Gga-040155	Gallus gallus	92.89	0.00e+00	728.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.10	4.00e-166	577.00
IUUC-Hsa-046585	Homo sapiens	100.00	0.00e+00	765.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	96.84	0.00e+00	727.00
IUUC-Lch-049795	Latimeria chalumnae	88.68	0.00e+00	696.00
IUUC-Loc-051985	Lepisosteus oculatus	88.19	0.00e+00	672.00
IUUC-Laf-054228	Loxodonta africana	95.26	0.00e+00	739.00
IUUC-Mcc-055402	Macaca mulatta	99.74	0.00e+00	765.00
IUUC-Mga-059374	Meleagris gallopavo	92.89	0.00e+00	728.00
IUUC-Mmr-061453	Microcebus murinus	98.42	0.00e+00	758.00
IUUC-Mdo-063080	Monodelphis domestica	91.84	0.00e+00	722.00
IUUC-Mmu-063529	Mus musculus	96.05	0.00e+00	726.00
IUUC-Mpu-066815	Mustela putorius furo	97.63	0.00e+00	753.00
IUUC-Mlu-067132	Myotis lucifugus	94.43	2.00e-165	574.00
IUUC-Nle-069371	Nomascus leucogenys	100.00	0.00e+00	765.00
IUUC-Opr-070948	Ochotona princeps	97.08	0.00e+00	710.00
IUUC-Ont-071410	Oreochromis niloticus	75.06	8.00e-164	569.00
IUUC-Oan-073304	Ornithorhynchus anatinus	91.83	2.00e-165	574.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.63	0.00e+00	730.00
IUUC-Ola-086808	Oryzias latipes	73.33	1.00e-161	562.00
IUUC-Oga-088391	Otolemur garnettii	98.95	0.00e+00	740.00
IUUC-Oar-090025	Ovis aries	82.63	9.00e-170	588.00
IUUC-Ptr-090975	Pan troglodytes	100.00	0.00e+00	765.00
IUUC-Pan-092287	Papio anubis	99.74	0.00e+00	765.00
IUUC-Psi-093413	Pelodiscus sinensis	93.42	0.00e+00	730.00
IUUC-Pfo-097129	Poecilia formosa	76.71	2.00e-169	588.00
IUUC-Pab-098756	Pongo abelii	100.00	0.00e+00	765.00
IUUC-Pca-100235	Procavia capensis	82.11	0.00e+00	648.00
IUUC-Pva-102294	Pteropus vampyrus	94.47	0.00e+00	720.00
IUUC-Rno-105090	Rattus norvegicus	95.79	0.00e+00	724.00
IUUC-Sha-107521	Sarcophilus harrisii	92.37	0.00e+00	726.00
IUUC-Sar-113697	Sorex araneus	89.32	0.00e+00	671.00
IUUC-Ssc-115958	Sus scrofa	88.29	7.00e-168	582.00
IUUC-Tgu-116559	Taeniopygia guttata	90.79	0.00e+00	703.00
IUUC-Tru-117677	Takifugu rubripes	76.46	1.00e-167	582.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.02	4.00e-165	573.00
IUUC-Tbe-127931	Tupaia belangeri	97.15	0.00e+00	638.00
IUUC-Ttr-128993	Tursiops truncatus	88.95	0.00e+00	655.00
IUUC-Xtr-132543	Xenopus tropicalis	83.99	0.00e+00	672.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence