iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013286

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

UBE3A protein

Genbank Nucleotide ID

DAAA02051638

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000002487.5	ENSBTAT00000049743.2	ENSBTAP00000046597.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.20e-108	361.3	548	874

Active Site

Position(s)	Description	Evidence
843	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 548  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 631
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 632  HFPMVVYRKLMGKKGTFLDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 718
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds +i+ Fwe++++f++e+++ fLq
   Q: 719  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVVIREFWEIVHSFTDEQKRLFLQ 807
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 808  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
           *****************...8888866666**************************************97 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MATACKRSSG EPQSDDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFRR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNCSDIKM NKKDGQGARD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATCTGTA AGAGCCTGAT TTTAGAATTC ACCAGCTCCT CAGAAGTTTG GCGAAATATG 60
GTATGTTTCT GTTTTATTTT TTGAAAGTCA AAATTGCATG AATATCTTAA TGTCATGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:533136

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	98.24	0.00e+00	1604.00
IUUC-Atr-003144	Amborella trichopoda	45.58	1.00e-95	343.00
IUUC-Apl-003742	Anas platyrhynchos	93.75	0.00e+00	1589.00
IUUC-Aca-004873	Anolis carolinensis	92.99	0.00e+00	1604.00
IUUC-Ame-011166	Astyanax mexicanus	86.13	0.00e+00	1455.00
IUUC-Cja-019707	Callithrix jacchus	96.90	0.00e+00	1610.00
IUUC-Cfa-020154	Canis familiaris	97.93	0.00e+00	1623.00
IUUC-Cpo-021292	Cavia porcellus	96.95	0.00e+00	1590.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	7.00e-83	300.00
IUUC-Csa-023378	Chlorocebus sabaeus	97.15	0.00e+00	1621.00
IUUC-Cho-025059	Choloepus hoffmanni	93.57	0.00e+00	1506.00
IUUC-Cin-025643	Ciona intestinalis	44.62	0.00e+00	714.00
IUUC-Csv-026282	Ciona savignyi	45.06	0.00e+00	676.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	1.00e-101	364.00
IUUC-Dre-027901	Danio rerio	85.18	0.00e+00	1434.00
IUUC-Dno-029320	Dasypus novemcinctus	97.37	0.00e+00	1635.00
IUUC-Dor-030756	Dipodomys ordii	93.58	0.00e+00	724.00
IUUC-Dme-032035	Drosophila melanogaster	43.31	2.00e-165	576.00
IUUC-Eca-033843	Equus caballus	97.66	0.00e+00	1570.00
IUUC-Eeu-035109	Erinaceus europaeus	96.01	0.00e+00	1553.00
IUUC-Fca-036344	Felis catus	96.35	0.00e+00	1633.00
IUUC-Fal-036747	Ficedula albicollis	93.75	0.00e+00	1590.00
IUUC-Gmo-038840	Gadus morhua	63.21	0.00e+00	1097.00
IUUC-Gga-040399	Gallus gallus	93.75	0.00e+00	1589.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.31	0.00e+00	1401.00
IUUC-Ggo-044804	Gorilla gorilla	97.13	0.00e+00	1613.00
IUUC-Hsa-045727	Homo sapiens	97.13	0.00e+00	1613.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	93.55	0.00e+00	1499.00
IUUC-Lch-050197	Latimeria chalumnae	90.59	0.00e+00	1539.00
IUUC-Loc-052743	Lepisosteus oculatus	88.22	0.00e+00	1521.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	5.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	95.51	0.00e+00	1592.00
IUUC-Mcc-054934	Macaca mulatta	97.24	0.00e+00	1608.00
IUUC-Meu-056061	Macropus eugenii	96.41	0.00e+00	1342.00
IUUC-Mga-059271	Meleagris gallopavo	92.27	0.00e+00	1551.00
IUUC-Mmr-061288	Microcebus murinus	97.12	0.00e+00	1611.00
IUUC-Mdo-062975	Monodelphis domestica	95.44	0.00e+00	1604.00
IUUC-Mmu-063674	Mus musculus	94.74	0.00e+00	1568.00
IUUC-Mpu-066568	Mustela putorius furo	98.29	0.00e+00	1651.00
IUUC-Mlu-067522	Myotis lucifugus	89.44	0.00e+00	1526.00
IUUC-Nle-069505	Nomascus leucogenys	97.13	0.00e+00	1613.00
IUUC-Opr-070570	Ochotona princeps	89.17	0.00e+00	1459.00
IUUC-Ont-071527	Oreochromis niloticus	85.68	0.00e+00	1464.00
IUUC-Oan-073446	Ornithorhynchus anatinus	89.98	0.00e+00	1053.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.12	0.00e+00	1627.00
IUUC-Ola-086996	Oryzias latipes	83.91	0.00e+00	1461.00
IUUC-Oga-088261	Otolemur garnettii	96.96	0.00e+00	1583.00
IUUC-Oar-090024	Ovis aries	100.00	0.00e+00	1649.00
IUUC-Ptr-090455	Pan troglodytes	97.13	0.00e+00	1613.00
IUUC-Pan-092509	Papio anubis	95.22	0.00e+00	1442.00
IUUC-Psi-092974	Pelodiscus sinensis	93.63	0.00e+00	1564.00
IUUC-Pma-094643	Petromyzon marinus	71.05	0.00e+00	1257.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	8.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	84.23	0.00e+00	1470.00
IUUC-Pab-097840	Pongo abelii	95.09	0.00e+00	1540.00
IUUC-Pca-100869	Procavia capensis	95.91	0.00e+00	1568.00
IUUC-Pva-103040	Pteropus vampyrus	96.43	0.00e+00	664.00
IUUC-Rno-105453	Rattus norvegicus	94.97	0.00e+00	1576.00
IUUC-Sha-107651	Sarcophilus harrisii	95.44	0.00e+00	1605.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	2.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	97.42	0.00e+00	1600.00
IUUC-Ssc-115979	Sus scrofa	98.71	0.00e+00	1615.00
IUUC-Tgu-116901	Taeniopygia guttata	93.75	0.00e+00	1589.00
IUUC-Tru-118368	Takifugu rubripes	85.55	0.00e+00	1466.00
IUUC-Tsy-119516	Tarsius syrichta	93.21	0.00e+00	1475.00
IUUC-Tni-120143	Tetraodon nigroviridis	84.87	0.00e+00	1459.00
IUUC-Tbe-127484	Tupaia belangeri	91.50	0.00e+00	1083.00
IUUC-Ttr-129078	Tursiops truncatus	99.30	0.00e+00	1613.00
IUUC-Vpa-130312	Vicugna pacos	90.65	0.00e+00	1370.00
IUUC-Xtr-132881	Xenopus tropicalis	91.04	0.00e+00	1540.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence