iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055314

UUCD1 version

UUC-MaM-00271

Ensembl Protein ID

ENSMMUP00000007439.3

UniProt Accession

G7N8J7; F6WD73; G7N8J7_MACMU

Genbank Protein ID

AFE79395.1; EHH21547.1

Protein Name

E3 ubiquitin-protein ligase HECW2

Genbank Nucleotide ID

JSUE03024599; CM001264

Gene Name

HECW2; EGK_04643

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005627.3	ENSMMUT00000007914.3	ENSMMUP00000007439.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-121	406.5	1240	1572

Active Site

Position(s)	Description	Evidence
1540	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1240 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1325
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1326 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1408
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1409 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1495
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1496 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
           **************************************************************************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTATAGA AGCTGTTTCT GACATCATCA GTTGACAGTA GAATAATAGG TTTTATTTTG 60
ACAGCAGAAG ATTACATGGT CAGGCTTTAA TAAACACTCT TTAAGGCTTT ATGTCTGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

mcc:697155

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	96.76	0.00e+00	3002.00
IUUC-Apl-003935	Anas platyrhynchos	85.82	0.00e+00	2732.00
IUUC-Aca-004558	Anolis carolinensis	83.54	0.00e+00	2654.00
IUUC-Ame-010893	Astyanax mexicanus	88.33	0.00e+00	1305.00
IUUC-Bta-013093	Bos taurus	96.47	0.00e+00	1583.00
IUUC-Cja-019651	Callithrix jacchus	97.41	0.00e+00	2904.00
IUUC-Cfa-021232	Canis familiaris	99.49	0.00e+00	1635.00
IUUC-Cpo-021770	Cavia porcellus	89.33	0.00e+00	2826.00
IUUC-Csa-023970	Chlorocebus sabaeus	99.68	0.00e+00	3019.00
IUUC-Cho-024512	Choloepus hoffmanni	89.31	0.00e+00	2654.00
IUUC-Csv-026127	Ciona savignyi	66.67	3.00e-155	541.00
IUUC-Dre-028275	Danio rerio	85.26	0.00e+00	1484.00
IUUC-Dno-029963	Dasypus novemcinctus	95.10	0.00e+00	2807.00
IUUC-Dor-030282	Dipodomys ordii	90.96	0.00e+00	2037.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	660.00
IUUC-Ete-033132	Echinops telfairi	83.18	0.00e+00	1264.00
IUUC-Eca-033978	Equus caballus	96.06	0.00e+00	2944.00
IUUC-Eeu-035278	Erinaceus europaeus	63.91	0.00e+00	1204.00
IUUC-Fca-036157	Felis catus	96.63	0.00e+00	2965.00
IUUC-Fal-037110	Ficedula albicollis	83.52	0.00e+00	2396.00
IUUC-Gmo-039291	Gadus morhua	80.00	0.00e+00	1015.00
IUUC-Gga-040821	Gallus gallus	86.24	0.00e+00	2726.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.38	0.00e+00	1905.00
IUUC-Ggo-044862	Gorilla gorilla	99.21	0.00e+00	2919.00
IUUC-Hsa-046219	Homo sapiens	99.24	0.00e+00	3080.00
IUUC-Lch-050526	Latimeria chalumnae	77.95	0.00e+00	2440.00
IUUC-Loc-052648	Lepisosteus oculatus	78.98	0.00e+00	1537.00
IUUC-Laf-054005	Loxodonta africana	95.99	0.00e+00	3001.00
IUUC-Meu-056356	Macropus eugenii	70.07	0.00e+00	1147.00
IUUC-Mga-060074	Meleagris gallopavo	86.16	0.00e+00	2624.00
IUUC-Mmr-061526	Microcebus murinus	96.76	0.00e+00	2940.00
IUUC-Mdo-063017	Monodelphis domestica	91.75	0.00e+00	2835.00
IUUC-Mmu-064165	Mus musculus	94.62	0.00e+00	2911.00
IUUC-Mpu-065835	Mustela putorius furo	82.74	0.00e+00	1574.00
IUUC-Mlu-067709	Myotis lucifugus	90.90	0.00e+00	2783.00
IUUC-Nle-069308	Nomascus leucogenys	98.92	0.00e+00	3039.00
IUUC-Opr-070330	Ochotona princeps	82.76	0.00e+00	2418.00
IUUC-Ont-071345	Oreochromis niloticus	75.63	0.00e+00	1468.00
IUUC-Ocu-074775	Oryctolagus cuniculus	95.42	0.00e+00	2657.00
IUUC-Ola-087225	Oryzias latipes	64.30	0.00e+00	1852.00
IUUC-Oga-088177	Otolemur garnettii	94.35	0.00e+00	2821.00
IUUC-Oar-089452	Ovis aries	96.37	0.00e+00	2960.00
IUUC-Ptr-090806	Pan troglodytes	99.05	0.00e+00	3070.00
IUUC-Pan-091838	Papio anubis	99.60	0.00e+00	2895.00
IUUC-Psi-094090	Pelodiscus sinensis	86.22	0.00e+00	2717.00
IUUC-Pfo-096520	Poecilia formosa	69.52	0.00e+00	1546.00
IUUC-Pab-098405	Pongo abelii	99.11	0.00e+00	3043.00
IUUC-Pca-100441	Procavia capensis	89.99	0.00e+00	2289.00
IUUC-Pva-102324	Pteropus vampyrus	99.12	0.00e+00	1628.00
IUUC-Rno-105943	Rattus norvegicus	94.23	0.00e+00	3004.00
IUUC-Sha-106985	Sarcophilus harrisii	87.70	0.00e+00	2363.00
IUUC-Sar-113505	Sorex araneus	95.58	0.00e+00	1545.00
IUUC-Ssc-115439	Sus scrofa	95.25	0.00e+00	1966.00
IUUC-Tgu-117078	Taeniopygia guttata	91.34	0.00e+00	1769.00
IUUC-Tru-118671	Takifugu rubripes	81.24	0.00e+00	1454.00
IUUC-Tni-120619	Tetraodon nigroviridis	87.02	0.00e+00	1434.00
IUUC-Tbe-127975	Tupaia belangeri	93.93	0.00e+00	2468.00
IUUC-Ttr-128469	Tursiops truncatus	91.03	0.00e+00	2683.00
IUUC-Vpa-130498	Vicugna pacos	86.03	0.00e+00	2478.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence