iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060074

UUCD1 version

UUC-MeG-00332

Ensembl Protein ID

ENSMGAP00000006887.2

UniProt Accession

G1N4T6; G1N4T6_MELGA

Protein Name

Uncharacterized protein

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006790.2	ENSMGAT00000007650.2	ENSMGAP00000006887.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-101	339.8	1239	1534

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1239 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1324
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt eNk+eY+++
   Q: 1325 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVT-ENKKEYIER 1406
           ************************************99...9***9.******************************.9******** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1407 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1493
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+
   Q: 1494 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPR 1534
           **********************************9999996 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQLR YTLSPENLQS LASQGTMAEN MNLQRANSDT DLVTSDSRSS 60
LTASMYEYTL GQSQNLIIFW DIKEEVDPTD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGTT CAGCACGAGA GCATCTGCTA TTTGTGCGAC GTCGCAACCC GCAGCTCCGG 60
TATACTCTAA GCCCAGAGAA TCTGCAGAGT TTGGCATCTC AGGGCACCAT GGCTGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	85.77	0.00e+00	2607.00
IUUC-Apl-003935	Anas platyrhynchos	96.62	0.00e+00	2938.00
IUUC-Aca-004558	Anolis carolinensis	86.40	0.00e+00	2632.00
IUUC-Ame-010893	Astyanax mexicanus	88.30	0.00e+00	1233.00
IUUC-Bta-013093	Bos taurus	94.98	0.00e+00	1488.00
IUUC-Cja-019651	Callithrix jacchus	85.08	0.00e+00	2484.00
IUUC-Cfa-021232	Canis familiaris	98.02	0.00e+00	1536.00
IUUC-Cpo-021770	Cavia porcellus	83.17	0.00e+00	2537.00
IUUC-Csa-023970	Chlorocebus sabaeus	85.89	0.00e+00	2595.00
IUUC-Cho-024512	Choloepus hoffmanni	78.58	0.00e+00	2296.00
IUUC-Dre-028275	Danio rerio	85.59	0.00e+00	1419.00
IUUC-Dno-029963	Dasypus novemcinctus	85.02	0.00e+00	2455.00
IUUC-Dor-030282	Dipodomys ordii	77.09	0.00e+00	1685.00
IUUC-Ete-033132	Echinops telfairi	82.12	0.00e+00	1246.00
IUUC-Eca-033978	Equus caballus	84.97	0.00e+00	2581.00
IUUC-Eeu-035278	Erinaceus europaeus	59.02	0.00e+00	1087.00
IUUC-Fca-036157	Felis catus	85.95	0.00e+00	2590.00
IUUC-Fal-037110	Ficedula albicollis	91.17	0.00e+00	2506.00
IUUC-Gmo-039291	Gadus morhua	78.80	0.00e+00	936.00
IUUC-Gga-040821	Gallus gallus	97.98	0.00e+00	2991.00
IUUC-Gac-042456	Gasterosteus aculeatus	80.82	0.00e+00	1290.00
IUUC-Ggo-044862	Gorilla gorilla	85.70	0.00e+00	2485.00
IUUC-Hsa-046219	Homo sapiens	85.89	0.00e+00	2632.00
IUUC-Lch-050526	Latimeria chalumnae	78.95	0.00e+00	2392.00
IUUC-Loc-052648	Lepisosteus oculatus	86.20	0.00e+00	1464.00
IUUC-Laf-054005	Loxodonta africana	85.92	0.00e+00	2624.00
IUUC-Mcc-055314	Macaca mulatta	85.76	0.00e+00	2585.00
IUUC-Meu-056356	Macropus eugenii	62.50	0.00e+00	1001.00
IUUC-Mmr-061526	Microcebus murinus	85.63	0.00e+00	2595.00
IUUC-Mdo-063017	Monodelphis domestica	86.41	0.00e+00	2574.00
IUUC-Mmu-064165	Mus musculus	84.53	0.00e+00	2544.00
IUUC-Mpu-065835	Mustela putorius furo	93.61	0.00e+00	1464.00
IUUC-Mlu-067709	Myotis lucifugus	82.19	0.00e+00	2474.00
IUUC-Nle-069308	Nomascus leucogenys	85.83	0.00e+00	2593.00
IUUC-Opr-070330	Ochotona princeps	74.65	0.00e+00	2094.00
IUUC-Ont-071345	Oreochromis niloticus	87.22	0.00e+00	1379.00
IUUC-Ocu-074775	Oryctolagus cuniculus	84.37	0.00e+00	2300.00
IUUC-Ola-087225	Oryzias latipes	80.97	0.00e+00	1275.00
IUUC-Oga-088177	Otolemur garnettii	83.59	0.00e+00	2508.00
IUUC-Oar-089452	Ovis aries	85.63	0.00e+00	2598.00
IUUC-Ptr-090806	Pan troglodytes	86.08	0.00e+00	2609.00
IUUC-Pan-091838	Papio anubis	85.64	0.00e+00	2470.00
IUUC-Psi-094090	Pelodiscus sinensis	89.97	0.00e+00	2713.00
IUUC-Pfo-096520	Poecilia formosa	65.55	0.00e+00	1895.00
IUUC-Pab-098405	Pongo abelii	85.83	0.00e+00	2598.00
IUUC-Pca-100441	Procavia capensis	79.26	0.00e+00	2033.00
IUUC-Pva-102324	Pteropus vampyrus	97.63	0.00e+00	1532.00
IUUC-Rno-105943	Rattus norvegicus	84.53	0.00e+00	2605.00
IUUC-Sha-106985	Sarcophilus harrisii	82.86	0.00e+00	2145.00
IUUC-Sar-113505	Sorex araneus	94.05	0.00e+00	1447.00
IUUC-Ssc-115439	Sus scrofa	79.98	0.00e+00	1677.00
IUUC-Tgu-117078	Taeniopygia guttata	91.12	0.00e+00	2717.00
IUUC-Tru-118671	Takifugu rubripes	82.08	0.00e+00	1388.00
IUUC-Tsy-119498	Tarsius syrichta	98.32	0.00e+00	706.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.93	0.00e+00	1357.00
IUUC-Tbe-127975	Tupaia belangeri	81.85	0.00e+00	2160.00
IUUC-Ttr-128469	Tursiops truncatus	80.00	0.00e+00	2327.00
IUUC-Vpa-130498	Vicugna pacos	76.36	0.00e+00	2214.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence