iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074775

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02003292

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000011694.3	ENSOCUT00000021121.2	ENSOCUP00000017112.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.50e-122	406.6	1105	1437

Active Site

Position(s)	Description	Evidence
1405	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1105 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1190
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1191 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1273
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1274 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1360
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1361 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1437
           **************************************************************************985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MEPEIKICFK YYHGISGALR ATTPCITVKN PAVMMGAEGM EGSASGNLHS RKLVSFTLSD 60
LRAVGLKKGM FFNPDPYLKM SIQPGKKSSF PTCAHHGQER RSTIISNTTN PIWHREKYSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTCTTAG GATGCCTGAA CAGTGATAGG ACTTGATGAG AGGCGGGATT GGCTTTCAGT 60
GTTGCTCCTA GCTGGTCAGG AGTCTCCAGG TAGAGGCCTG TGCAAATTCC ACCTAGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	94.93	0.00e+00	2642.00
IUUC-Apl-003935	Anas platyrhynchos	83.99	0.00e+00	2407.00
IUUC-Aca-004558	Anolis carolinensis	82.29	0.00e+00	2373.00
IUUC-Ame-010893	Astyanax mexicanus	88.47	0.00e+00	1306.00
IUUC-Bta-013093	Bos taurus	96.72	0.00e+00	1585.00
IUUC-Cja-019651	Callithrix jacchus	94.10	0.00e+00	2653.00
IUUC-Cfa-021232	Canis familiaris	99.75	0.00e+00	1638.00
IUUC-Cpo-021770	Cavia porcellus	88.79	0.00e+00	2526.00
IUUC-Csa-023970	Chlorocebus sabaeus	95.35	0.00e+00	2632.00
IUUC-Cho-024512	Choloepus hoffmanni	86.81	0.00e+00	2321.00
IUUC-Csv-026127	Ciona savignyi	72.27	4.00e-155	541.00
IUUC-Dre-028275	Danio rerio	85.73	0.00e+00	1492.00
IUUC-Dno-029963	Dasypus novemcinctus	93.00	0.00e+00	2573.00
IUUC-Dor-030282	Dipodomys ordii	88.01	0.00e+00	1678.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	660.00
IUUC-Ete-033132	Echinops telfairi	83.31	0.00e+00	1266.00
IUUC-Eca-033978	Equus caballus	94.31	0.00e+00	2608.00
IUUC-Eeu-035278	Erinaceus europaeus	60.35	0.00e+00	907.00
IUUC-Fca-036157	Felis catus	94.80	0.00e+00	2618.00
IUUC-Fal-037110	Ficedula albicollis	80.52	0.00e+00	2280.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1018.00
IUUC-Gga-040821	Gallus gallus	84.23	0.00e+00	2401.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.02	0.00e+00	1701.00
IUUC-Ggo-044862	Gorilla gorilla	95.36	0.00e+00	2636.00
IUUC-Hsa-046219	Homo sapiens	95.49	0.00e+00	2670.00
IUUC-Lch-050526	Latimeria chalumnae	76.52	0.00e+00	2184.00
IUUC-Loc-052648	Lepisosteus oculatus	88.37	0.00e+00	1538.00
IUUC-Laf-054005	Loxodonta africana	94.45	0.00e+00	2640.00
IUUC-Mcc-055314	Macaca mulatta	95.42	0.00e+00	2629.00
IUUC-Meu-056356	Macropus eugenii	68.85	0.00e+00	838.00
IUUC-Mga-060074	Meleagris gallopavo	84.16	0.00e+00	2301.00
IUUC-Mmr-061526	Microcebus murinus	95.35	0.00e+00	2620.00
IUUC-Mdo-063017	Monodelphis domestica	90.44	0.00e+00	2510.00
IUUC-Mmu-064165	Mus musculus	93.23	0.00e+00	2592.00
IUUC-Mpu-065835	Mustela putorius furo	82.57	0.00e+00	1560.00
IUUC-Mlu-067709	Myotis lucifugus	90.01	0.00e+00	2496.00
IUUC-Nle-069308	Nomascus leucogenys	95.21	0.00e+00	2641.00
IUUC-Opr-070330	Ochotona princeps	83.12	0.00e+00	2183.00
IUUC-Ont-071345	Oreochromis niloticus	87.56	0.00e+00	1455.00
IUUC-Ola-087225	Oryzias latipes	80.71	0.00e+00	1345.00
IUUC-Oga-088177	Otolemur garnettii	94.58	0.00e+00	2559.00
IUUC-Oar-089452	Ovis aries	94.86	0.00e+00	2635.00
IUUC-Ptr-090806	Pan troglodytes	95.21	0.00e+00	2653.00
IUUC-Pan-091838	Papio anubis	95.36	0.00e+00	2625.00
IUUC-Psi-094090	Pelodiscus sinensis	84.56	0.00e+00	2398.00
IUUC-Pfo-096520	Poecilia formosa	68.93	0.00e+00	1528.00
IUUC-Pab-098405	Pongo abelii	95.35	0.00e+00	2646.00
IUUC-Pca-100441	Procavia capensis	87.75	0.00e+00	1959.00
IUUC-Pva-102324	Pteropus vampyrus	99.37	0.00e+00	1632.00
IUUC-Rno-105943	Rattus norvegicus	92.95	0.00e+00	2666.00
IUUC-Sha-106985	Sarcophilus harrisii	88.06	0.00e+00	2308.00
IUUC-Sar-113505	Sorex araneus	95.83	0.00e+00	1546.00
IUUC-Ssc-115439	Sus scrofa	92.89	0.00e+00	1639.00
IUUC-Tgu-117078	Taeniopygia guttata	96.70	0.00e+00	1649.00
IUUC-Tru-118671	Takifugu rubripes	84.00	0.00e+00	1453.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.89	0.00e+00	1432.00
IUUC-Tbe-127975	Tupaia belangeri	91.93	0.00e+00	2139.00
IUUC-Ttr-128469	Tursiops truncatus	88.90	0.00e+00	2358.00
IUUC-Vpa-130498	Vicugna pacos	83.81	0.00e+00	2132.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence