iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094090

Ensembl Protein ID

ENSPSIP00000015686.1

UniProt Accession

K7G5X5; K7G5X5_PELSI

Genbank Protein ID

ENSPSIP00000015686

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01051137

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000013756.1	ENSPSIT00000015760.1	ENSPSIP00000015686.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-121	405.2	1243	1575

Active Site

Position(s)	Description	Evidence
1543	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1243 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1328
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1329 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1411
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1412 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1498
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l ekLl+A+eet+ F+l+
   Q: 1499 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLCEKLLTAVEETSTFGLE 1575
           **************************************************************************985 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MANSAREHLL FVRRRNPQLR YTLSPENLQS LASQGTIPEN MNLQRANSDT DLVTSDSRSS 60
LTASMYEYTL GQSQNLIIFW DIKEEVDPTD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAAATT CAGCCAGAGA ACATCTGCTT TTTGTGCGAC GTCGTAATCC TCAGCTACGG 60
TATACTCTGA GCCCAGAGAA TCTACAGAGT CTGGCATCTC AGGGCACCAT ACCTGAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	85.59	0.00e+00	2657.00
IUUC-Apl-003935	Anas platyrhynchos	90.42	0.00e+00	2800.00
IUUC-Aca-004558	Anolis carolinensis	87.19	0.00e+00	2719.00
IUUC-Ame-010893	Astyanax mexicanus	88.24	0.00e+00	1278.00
IUUC-Bta-013093	Bos taurus	94.72	0.00e+00	1532.00
IUUC-Cja-019651	Callithrix jacchus	84.77	0.00e+00	2539.00
IUUC-Cfa-021232	Canis familiaris	97.23	0.00e+00	1575.00
IUUC-Cpo-021770	Cavia porcellus	83.01	0.00e+00	2595.00
IUUC-Csa-023970	Chlorocebus sabaeus	85.58	0.00e+00	2651.00
IUUC-Cho-024512	Choloepus hoffmanni	78.37	0.00e+00	2360.00
IUUC-Csv-026127	Ciona savignyi	66.67	1.00e-154	538.00
IUUC-Dre-028275	Danio rerio	85.43	0.00e+00	1447.00
IUUC-Dno-029963	Dasypus novemcinctus	84.79	0.00e+00	2503.00
IUUC-Dor-030282	Dipodomys ordii	76.33	0.00e+00	1685.00
IUUC-Dme-032217	Drosophila melanogaster	70.95	0.00e+00	646.00
IUUC-Ete-033132	Echinops telfairi	81.40	0.00e+00	1229.00
IUUC-Eca-033978	Equus caballus	85.06	0.00e+00	2637.00
IUUC-Eeu-035278	Erinaceus europaeus	96.93	0.00e+00	737.00
IUUC-Fca-036157	Felis catus	85.25	0.00e+00	2618.00
IUUC-Fal-037110	Ficedula albicollis	96.57	0.00e+00	1622.00
IUUC-Gmo-039291	Gadus morhua	79.91	0.00e+00	1007.00
IUUC-Gga-040821	Gallus gallus	90.36	0.00e+00	2809.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.20	0.00e+00	1895.00
IUUC-Ggo-044862	Gorilla gorilla	85.25	0.00e+00	2550.00
IUUC-Hsa-046219	Homo sapiens	85.58	0.00e+00	2699.00
IUUC-Lch-050526	Latimeria chalumnae	80.16	0.00e+00	2459.00
IUUC-Loc-052648	Lepisosteus oculatus	86.81	0.00e+00	1493.00
IUUC-Laf-054005	Loxodonta africana	85.82	0.00e+00	2665.00
IUUC-Mcc-055314	Macaca mulatta	85.58	0.00e+00	2647.00
IUUC-Meu-056356	Macropus eugenii	64.90	0.00e+00	1047.00
IUUC-Mga-060074	Meleagris gallopavo	89.77	0.00e+00	2701.00
IUUC-Mmr-061526	Microcebus murinus	85.08	0.00e+00	2638.00
IUUC-Mdo-063017	Monodelphis domestica	87.35	0.00e+00	2691.00
IUUC-Mmu-064165	Mus musculus	84.63	0.00e+00	2612.00
IUUC-Mpu-065835	Mustela putorius furo	81.04	0.00e+00	1520.00
IUUC-Mlu-067709	Myotis lucifugus	83.20	0.00e+00	2544.00
IUUC-Nle-069308	Nomascus leucogenys	85.13	0.00e+00	2657.00
IUUC-Opr-070330	Ochotona princeps	72.74	0.00e+00	2124.00
IUUC-Ont-071345	Oreochromis niloticus	87.55	0.00e+00	1424.00
IUUC-Ocu-074775	Oryctolagus cuniculus	84.34	0.00e+00	2358.00
IUUC-Ola-087225	Oryzias latipes	63.67	0.00e+00	1835.00
IUUC-Oga-088177	Otolemur garnettii	83.57	0.00e+00	2542.00
IUUC-Oar-089452	Ovis aries	85.71	0.00e+00	2642.00
IUUC-Ptr-090806	Pan troglodytes	85.44	0.00e+00	2672.00
IUUC-Pan-091838	Papio anubis	85.25	0.00e+00	2529.00
IUUC-Pfo-096520	Poecilia formosa	68.13	0.00e+00	1481.00
IUUC-Pab-098405	Pongo abelii	85.65	0.00e+00	2668.00
IUUC-Pca-100441	Procavia capensis	77.73	0.00e+00	1979.00
IUUC-Pva-102324	Pteropus vampyrus	96.74	0.00e+00	1568.00
IUUC-Rno-105943	Rattus norvegicus	84.49	0.00e+00	2679.00
IUUC-Sha-106985	Sarcophilus harrisii	84.45	0.00e+00	2251.00
IUUC-Sar-113505	Sorex araneus	93.33	0.00e+00	1483.00
IUUC-Ssc-115439	Sus scrofa	79.64	0.00e+00	1684.00
IUUC-Tgu-117078	Taeniopygia guttata	86.70	0.00e+00	2670.00
IUUC-Tru-118671	Takifugu rubripes	84.62	0.00e+00	1415.00
IUUC-Tni-120619	Tetraodon nigroviridis	84.38	0.00e+00	1403.00
IUUC-Tbe-127975	Tupaia belangeri	81.47	0.00e+00	2142.00
IUUC-Ttr-128469	Tursiops truncatus	79.82	0.00e+00	2389.00
IUUC-Vpa-130498	Vicugna pacos	75.84	0.00e+00	2221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence