iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120619

UUCD1 version

UUC-TeN-00744

Ensembl Protein ID

ENSTNIP00000016242.1

UniProt Accession

H3D6V1; H3D6V1_TETNG

Protein Name

Uncharacterized protein

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000013257.1	ENSTNIT00000016454.1	ENSTNIP00000016242.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-119	399.5	1113	1443

Active Site

Position(s)	Description	Evidence
1411	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+y  nd++t+q++p+++++  +h ++F+f Gr+lg+al ++ lld
   Q: 1113 DLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYA-NDTYTVQISPSAFVD--NHHRVFRFSGRILGLALIHQYLLD 1196
           456689************************************986.589**********96..8*********************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG+ni V ++Nk+eY+++
   Q: 1197 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGANIAVSEKNKKEYIER 1279
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1280 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1366
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s ++l+ek+l+A+eet+ F+l+
   Q: 1367 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSVLYEKMLTAVEETSTFGLE 1443
           **************************************************************************985 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

GVGLQRANSD TDLVTSDSRS SLTASTYQLT LGHGHLVIFW DIKEEVDATD WIGLYHIDET 60
CVANMWDSKN RGVNGTQRGQ IVWRLEPGPY FMESETKICF KYYHGISGAL RATTPCITVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTGGGGC TCCAGCGTGC TAACAGTGAC ACAGACCTGG TGACATCAGA CAGCCGGTCT 60
TCTCTCACAG CGTCTACGTA CCAGCTGACG CTGGGCCACG GCCACCTGGT CATCTTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003935	Anas platyrhynchos	85.87	0.00e+00	1435.00
IUUC-Aca-004558	Anolis carolinensis	86.80	0.00e+00	1427.00
IUUC-Ame-010893	Astyanax mexicanus	90.86	0.00e+00	1311.00
IUUC-Bta-013093	Bos taurus	85.48	0.00e+00	1394.00
IUUC-Cel-018137	Caenorhabditis elegans	30.76	7.00e-101	361.00
IUUC-Cja-019651	Callithrix jacchus	84.42	0.00e+00	1432.00
IUUC-Cfa-021232	Canis familiaris	87.39	0.00e+00	1420.00
IUUC-Cpo-021770	Cavia porcellus	87.69	0.00e+00	1448.00
IUUC-Csa-023970	Chlorocebus sabaeus	87.39	0.00e+00	1431.00
IUUC-Cho-024512	Choloepus hoffmanni	78.38	0.00e+00	1225.00
IUUC-Csv-026127	Ciona savignyi	71.71	3.00e-150	524.00
IUUC-Dre-028275	Danio rerio	90.74	0.00e+00	1474.00
IUUC-Dme-032217	Drosophila melanogaster	70.48	0.00e+00	635.00
IUUC-Ete-033132	Echinops telfairi	73.25	0.00e+00	1098.00
IUUC-Eca-033978	Equus caballus	87.14	0.00e+00	1420.00
IUUC-Fal-037110	Ficedula albicollis	85.01	0.00e+00	1430.00
IUUC-Gga-040821	Gallus gallus	88.20	0.00e+00	1433.00
IUUC-Gac-042181	Gasterosteus aculeatus	76.71	0.00e+00	2210.00
IUUC-Lch-050526	Latimeria chalumnae	85.98	0.00e+00	1416.00
IUUC-Loc-052648	Lepisosteus oculatus	87.77	0.00e+00	1466.00
IUUC-Laf-054005	Loxodonta africana	85.47	0.00e+00	1436.00
IUUC-Mcc-055314	Macaca mulatta	87.52	0.00e+00	1431.00
IUUC-Meu-056356	Macropus eugenii	76.63	0.00e+00	743.00
IUUC-Mga-060074	Meleagris gallopavo	87.30	0.00e+00	1356.00
IUUC-Mmr-061526	Microcebus murinus	87.19	0.00e+00	1427.00
IUUC-Mdo-063017	Monodelphis domestica	65.83	0.00e+00	1885.00
IUUC-Mpu-065835	Mustela putorius furo	87.61	0.00e+00	1368.00
IUUC-Mlu-067709	Myotis lucifugus	85.68	0.00e+00	1389.00
IUUC-Ont-071345	Oreochromis niloticus	91.69	0.00e+00	1496.00
IUUC-Ocu-074775	Oryctolagus cuniculus	87.39	0.00e+00	1430.00
IUUC-Oga-088177	Otolemur garnettii	87.61	0.00e+00	1426.00
IUUC-Oar-089452	Ovis aries	85.91	0.00e+00	1430.00
IUUC-Psi-094090	Pelodiscus sinensis	84.70	0.00e+00	1403.00
IUUC-Pfo-096520	Poecilia formosa	74.56	0.00e+00	2144.00
IUUC-Pva-102324	Pteropus vampyrus	86.79	0.00e+00	1412.00
IUUC-Sha-106985	Sarcophilus harrisii	84.39	0.00e+00	1341.00
IUUC-Sar-113505	Sorex araneus	83.98	0.00e+00	1339.00
IUUC-Ssc-115534	Sus scrofa	95.30	0.00e+00	717.00
IUUC-Tgu-117078	Taeniopygia guttata	84.70	0.00e+00	1427.00
IUUC-Tru-118671	Takifugu rubripes	87.41	0.00e+00	2506.00
IUUC-Tsy-119379	Tarsius syrichta	70.06	0.00e+00	673.00
IUUC-Ttr-128469	Tursiops truncatus	77.55	0.00e+00	1208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence