iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118671

UUCD1 version

UUC-TaR-00648

Ensembl Protein ID

ENSTRUP00000030770.1

UniProt Accession

H2U1F9; H2U1F9_TAKRU

Protein Name

Uncharacterized protein

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012162.1	ENSTRUT00000030887.1	ENSTRUP00000030770.1
ENSTRUG00000012162.1	ENSTRUT00000030888.1	ENSTRUP00000030771.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-120	403.8	1211	1543

Active Site

Position(s)	Description	Evidence
1511	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1211 DLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1296
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG+ni V ++Nk+eY+++
   Q: 1297 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGANIAVSEKNKKEYIER 1379
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+ +elel+i G++eid++d++ +t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1380 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDGRELELVIAGTAEIDLSDWRHNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1466
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ek+l+A+eet+ F+l+
   Q: 1467 LLQFVTGTSSIPYEGFAALRgsngPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTFGLE 1543
           **************************************************************************985 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

SSSPSTSTGN GSARDHLLAV RRRTPHTRPY TIGPENLRSL SVQGEQPEAA GVGLQRANSD 60
TDLVTSDSRS SLTASTYQLT LGHGHLVIFW DIKEEVDATD WIGLYHIDET CVANMWDSKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTCATCAC CATCCACATC AACTGGAAAT GGCAGCGCCC GAGACCACCT CCTGGCAGTG 60
CGCCGGCGCA CCCCACACAC CCGGCCATAT ACGATTGGCC CTGAAAACCT CCGCAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	83.47	0.00e+00	1459.00
IUUC-Apl-003935	Anas platyrhynchos	86.50	0.00e+00	1452.00
IUUC-Aca-004558	Anolis carolinensis	87.19	0.00e+00	1438.00
IUUC-Ame-010893	Astyanax mexicanus	91.56	0.00e+00	1328.00
IUUC-Bta-013093	Bos taurus	85.68	0.00e+00	1400.00
IUUC-Cja-019651	Callithrix jacchus	84.13	0.00e+00	1451.00
IUUC-Cfa-021232	Canis familiaris	87.77	0.00e+00	1436.00
IUUC-Cpo-021770	Cavia porcellus	87.82	0.00e+00	1459.00
IUUC-Csa-023970	Chlorocebus sabaeus	83.89	0.00e+00	1445.00
IUUC-Cho-024512	Choloepus hoffmanni	78.13	0.00e+00	1229.00
IUUC-Csv-026127	Ciona savignyi	66.92	5.00e-156	543.00
IUUC-Dre-028275	Danio rerio	85.60	0.00e+00	1509.00
IUUC-Dno-029963	Dasypus novemcinctus	81.63	0.00e+00	1431.00
IUUC-Dor-031030	Dipodomys ordii	68.18	0.00e+00	768.00
IUUC-Dme-032217	Drosophila melanogaster	71.00	0.00e+00	654.00
IUUC-Ete-033132	Echinops telfairi	73.25	0.00e+00	1103.00
IUUC-Eca-033978	Equus caballus	87.26	0.00e+00	1431.00
IUUC-Fca-036157	Felis catus	84.46	0.00e+00	1439.00
IUUC-Fal-037110	Ficedula albicollis	86.15	0.00e+00	1446.00
IUUC-Gga-040821	Gallus gallus	88.58	0.00e+00	1449.00
IUUC-Gac-042181	Gasterosteus aculeatus	76.82	0.00e+00	2293.00
IUUC-Lch-050526	Latimeria chalumnae	81.59	0.00e+00	1438.00
IUUC-Loc-052648	Lepisosteus oculatus	86.57	0.00e+00	1511.00
IUUC-Laf-054005	Loxodonta africana	66.83	0.00e+00	1987.00
IUUC-Mcc-055314	Macaca mulatta	83.77	0.00e+00	1442.00
IUUC-Meu-056356	Macropus eugenii	77.24	0.00e+00	762.00
IUUC-Mga-060074	Meleagris gallopavo	87.57	0.00e+00	1369.00
IUUC-Mmr-061526	Microcebus murinus	87.44	0.00e+00	1441.00
IUUC-Mdo-063017	Monodelphis domestica	84.27	0.00e+00	1416.00
IUUC-Mmu-064165	Mus musculus	83.22	0.00e+00	1437.00
IUUC-Mpu-065835	Mustela putorius furo	87.87	0.00e+00	1379.00
IUUC-Mlu-067709	Myotis lucifugus	82.17	0.00e+00	1413.00
IUUC-Nle-069308	Nomascus leucogenys	81.86	0.00e+00	1445.00
IUUC-Opr-070330	Ochotona princeps	72.61	0.00e+00	1206.00
IUUC-Ont-071345	Oreochromis niloticus	73.57	0.00e+00	2256.00
IUUC-Ocu-074775	Oryctolagus cuniculus	83.89	0.00e+00	1448.00
IUUC-Oga-088177	Otolemur garnettii	83.25	0.00e+00	1440.00
IUUC-Oar-089452	Ovis aries	83.69	0.00e+00	1442.00
IUUC-Pan-091838	Papio anubis	83.67	0.00e+00	1436.00
IUUC-Psi-094090	Pelodiscus sinensis	85.01	0.00e+00	1405.00
IUUC-Pfo-096520	Poecilia formosa	76.69	0.00e+00	2249.00
IUUC-Pab-098405	Pongo abelii	81.13	0.00e+00	1447.00
IUUC-Pva-102324	Pteropus vampyrus	87.14	0.00e+00	1431.00
IUUC-Rno-105943	Rattus norvegicus	80.20	0.00e+00	1444.00
IUUC-Sha-106985	Sarcophilus harrisii	79.33	0.00e+00	1366.00
IUUC-Sar-113505	Sorex araneus	84.24	0.00e+00	1353.00
IUUC-Ssc-115534	Sus scrofa	96.41	0.00e+00	736.00
IUUC-Tgu-117078	Taeniopygia guttata	85.84	0.00e+00	1444.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.80	0.00e+00	2541.00
IUUC-Ttr-128469	Tursiops truncatus	74.09	0.00e+00	1228.00
IUUC-Vpa-130498	Vicugna pacos	64.98	0.00e+00	1038.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence