iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004245

UUCD1 version

UUC-AnC-00407

Ensembl Protein ID

ENSACAP00000016617.3

UniProt Accession

H9GNP6; H9GNP6_ANOCA

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016855.3	ENSACAT00000016944.3	ENSACAP00000016617.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.80e-37	127.7	117	285
UBD/ZnF/ZnF_A20	1.50e-21	75.9	797	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak. 76
           + lkt+gDGnCL++A+sq+++gv+d d+ l++al++aL+e  ++++    q+e  + +ef+ ++        ede+e++ k+ + e+  
   Q: 117  MSLKTNGDGNCLMHAASQYMWGVQDVDLvLRKALFHALKEVDTRNFklrwQRETLKSQEFVATGlcydtrnwEDEWENLIKMSSAETSv 205
           5789********************************************************************************99443 PP
   S: 77   g.........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLv 136
           +         eeihif+L +iL+rpiivv++++l+s          +vggi+lpl++p e+ +++pivL+Y+s+H+ +L+
   Q: 206  AqhglqynslEEIHIFVLVNILRRPIIVVADKMLRSlqsgssfsplNVGGIYLPLHWPTEEcYRYPIVLAYDSMHFTPLI 285
           355699999********************************************************************996 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrr 33
           +k++C++ +C++YGn ++ gyC++Cy++++ +
   Q: 797  PKQRCRApACDHYGNTKCHGYCNECYQFKQIY 828
           69***************************977 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MGFRRKRRIS PALSKQTASS SNRMASPQII PQALYLSNML KAVKIRERMP EDLVKCTNGI 60
IHHFKTMHRY TIEMFRMCQF CPQFQELLQK ALFDQATQTS LEHQRKLNWC REVKKLMSLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCACCGCAA ATGTCACATG CCTCCCGCGG GAAAGTCCCC TCGCTCGCTC TCTCTGCGGT 60
TCTGAAAATC CCAGCCCCTT TTTCCCCCTT GCATTGGGGT GAAGGGAAGG GGCCCGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20
IPR001781--Znf_LIM

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

acs:100564334

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	64.18	0.00e+00	1051.00
IUUC-Apl-003501	Anas platyrhynchos	68.94	0.00e+00	1109.00
IUUC-Ame-011789	Astyanax mexicanus	46.81	0.00e+00	699.00
IUUC-Bta-012664	Bos taurus	62.16	0.00e+00	1008.00
IUUC-Cja-019895	Callithrix jacchus	63.93	0.00e+00	1051.00
IUUC-Cfa-020754	Canis familiaris	65.05	0.00e+00	1068.00
IUUC-Cpo-021780	Cavia porcellus	63.52	0.00e+00	1031.00
IUUC-Csa-023568	Chlorocebus sabaeus	64.68	0.00e+00	1066.00
IUUC-Cho-024300	Choloepus hoffmanni	75.00	3.00e-159	555.00
IUUC-Dre-028577	Danio rerio	48.53	0.00e+00	686.00
IUUC-Dno-029382	Dasypus novemcinctus	62.33	0.00e+00	1022.00
IUUC-Dor-030874	Dipodomys ordii	61.44	0.00e+00	995.00
IUUC-Ete-032721	Echinops telfairi	74.58	0.00e+00	663.00
IUUC-Eca-033596	Equus caballus	62.21	0.00e+00	1009.00
IUUC-Eeu-035159	Erinaceus europaeus	60.09	0.00e+00	773.00
IUUC-Fca-035847	Felis catus	64.30	0.00e+00	1059.00
IUUC-Fal-036681	Ficedula albicollis	68.56	0.00e+00	1136.00
IUUC-Gmo-038521	Gadus morhua	60.89	2.00e-148	519.00
IUUC-Gga-040975	Gallus gallus	70.17	0.00e+00	1145.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.90	2.00e-154	539.00
IUUC-Ggo-045258	Gorilla gorilla	64.30	0.00e+00	1058.00
IUUC-Hsa-046071	Homo sapiens	64.43	0.00e+00	1061.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	63.68	0.00e+00	1051.00
IUUC-Lch-050326	Latimeria chalumnae	55.71	0.00e+00	894.00
IUUC-Loc-051945	Lepisosteus oculatus	45.47	8.00e-180	623.00
IUUC-Laf-053722	Loxodonta africana	64.14	0.00e+00	1059.00
IUUC-Mcc-055503	Macaca mulatta	64.43	0.00e+00	1060.00
IUUC-Meu-056481	Macropus eugenii	60.02	0.00e+00	949.00
IUUC-Mga-059690	Meleagris gallopavo	65.39	0.00e+00	1042.00
IUUC-Mmr-061233	Microcebus murinus	63.86	0.00e+00	1028.00
IUUC-Mdo-062446	Monodelphis domestica	65.47	0.00e+00	1083.00
IUUC-Mmu-063436	Mus musculus	63.81	0.00e+00	1031.00
IUUC-Mpu-066808	Mustela putorius furo	64.93	0.00e+00	1065.00
IUUC-Mlu-067339	Myotis lucifugus	63.61	0.00e+00	1028.00
IUUC-Nle-069888	Nomascus leucogenys	64.43	0.00e+00	1063.00
IUUC-Opr-070303	Ochotona princeps	64.40	0.00e+00	1044.00
IUUC-Ont-072283	Oreochromis niloticus	59.53	9.00e-150	523.00
IUUC-Oan-072925	Ornithorhynchus anatinus	64.79	0.00e+00	1091.00
IUUC-Ocu-073889	Oryctolagus cuniculus	64.43	0.00e+00	1053.00
IUUC-Ola-087417	Oryzias latipes	60.49	5.00e-149	521.00
IUUC-Oga-088708	Otolemur garnettii	62.19	0.00e+00	990.00
IUUC-Oar-089271	Ovis aries	62.70	0.00e+00	1023.00
IUUC-Ptr-091296	Pan troglodytes	64.43	0.00e+00	1061.00
IUUC-Pan-092474	Papio anubis	64.55	0.00e+00	1063.00
IUUC-Psi-093447	Pelodiscus sinensis	70.74	0.00e+00	1160.00
IUUC-Pfo-096511	Poecilia formosa	43.68	0.00e+00	651.00
IUUC-Pab-098700	Pongo abelii	64.43	0.00e+00	1061.00
IUUC-Pca-100246	Procavia capensis	60.10	0.00e+00	698.00
IUUC-Pva-102606	Pteropus vampyrus	62.15	3.00e-142	499.00
IUUC-Rno-105818	Rattus norvegicus	63.96	0.00e+00	1047.00
IUUC-Sha-106559	Sarcophilus harrisii	64.85	0.00e+00	1073.00
IUUC-Sit-110516	Setaria italica	44.44	8.00e-02	33.10
IUUC-Sar-113454	Sorex araneus	77.23	6.00e-157	547.00
IUUC-Ssc-116064	Sus scrofa	63.31	0.00e+00	1032.00
IUUC-Tgu-117212	Taeniopygia guttata	67.62	0.00e+00	1116.00
IUUC-Tru-118230	Takifugu rubripes	61.22	8.00e-153	534.00
IUUC-Tsy-119066	Tarsius syrichta	62.89	0.00e+00	1035.00
IUUC-Tni-119825	Tetraodon nigroviridis	45.93	0.00e+00	660.00
IUUC-Tbe-127601	Tupaia belangeri	78.46	9.00e-161	560.00
IUUC-Ttr-128930	Tursiops truncatus	62.22	0.00e+00	1016.00
IUUC-Vpa-130450	Vicugna pacos	75.63	0.00e+00	647.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence