iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021780

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02045845

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010771.3	ENSCPOT00000010869.2	ENSCPOP00000009670.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	4.90e-38	130.6	93	263
UBD/ZnF/ZnF_A20	3.40e-23	81.3	758	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe..a 75
           ++lkt+gDGnCL++A+ q+l+gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++        +de++++ ++++++  a
   Q: 93   VALKTNGDGNCLMHATCQYLWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLVRMASTDspA 181
           789**********************************************9***********************************9663 PP
   S: 76   kg........eeihifaLaqiLsrpiivvdvdsles...........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
            +        eeihif+L++iL+rp+iv+++d++ +           kvggi+lpl++p+++ +++pivL+Y+s+H+ +Lv+
   Q: 182  ACcglqysslEEIHIFVLCNILRRPVIVISADKMLRslesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSHHFVPLVT 263
           32579999*********************98877667*******************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +k++C++ +C+++Gn ++ngyC++C++++++++
   Q: 758  PKQRCRApACDHFGNSKCNGYCNECFQFKQMYG 790
           79*****************************96 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF 60
REIIHKALID RNLQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHATCQ YLWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAC AACTCCTTCC TCAGGCTTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG 60
ATAAGAGAGA GAACTCCAGA AGACATTTTC AAACCTACCA ACGGGATCAT CCATCATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	88.13	0.00e+00	1436.00
IUUC-Apl-003501	Anas platyrhynchos	65.07	0.00e+00	1013.00
IUUC-Aca-004245	Anolis carolinensis	63.40	0.00e+00	1031.00
IUUC-Ame-011789	Astyanax mexicanus	46.80	0.00e+00	677.00
IUUC-Bta-012664	Bos taurus	85.34	0.00e+00	1350.00
IUUC-Cja-019895	Callithrix jacchus	89.77	0.00e+00	1462.00
IUUC-Cfa-020754	Canis familiaris	87.88	0.00e+00	1441.00
IUUC-Csa-023568	Chlorocebus sabaeus	90.15	0.00e+00	1475.00
IUUC-Cho-024300	Choloepus hoffmanni	88.66	0.00e+00	640.00
IUUC-Dre-028577	Danio rerio	47.90	0.00e+00	668.00
IUUC-Dno-029382	Dasypus novemcinctus	82.58	0.00e+00	1306.00
IUUC-Dor-030874	Dipodomys ordii	85.73	0.00e+00	1380.00
IUUC-Ete-032721	Echinops telfairi	91.17	0.00e+00	795.00
IUUC-Eca-033596	Equus caballus	84.94	0.00e+00	1378.00
IUUC-Eeu-035159	Erinaceus europaeus	84.76	0.00e+00	1089.00
IUUC-Fca-035847	Felis catus	88.51	0.00e+00	1444.00
IUUC-Fal-036681	Ficedula albicollis	64.39	0.00e+00	1030.00
IUUC-Gmo-038521	Gadus morhua	58.33	3.00e-143	502.00
IUUC-Gga-040975	Gallus gallus	63.04	0.00e+00	1018.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.14	3.00e-149	522.00
IUUC-Ggo-045258	Gorilla gorilla	89.39	0.00e+00	1464.00
IUUC-Hsa-046071	Homo sapiens	89.65	0.00e+00	1466.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	90.91	0.00e+00	1467.00
IUUC-Lch-050326	Latimeria chalumnae	56.84	0.00e+00	897.00
IUUC-Loc-051945	Lepisosteus oculatus	45.38	5.00e-176	611.00
IUUC-Laf-053722	Loxodonta africana	88.01	0.00e+00	1402.00
IUUC-Mcc-055503	Macaca mulatta	89.90	0.00e+00	1470.00
IUUC-Meu-056481	Macropus eugenii	73.09	0.00e+00	1136.00
IUUC-Mga-059690	Meleagris gallopavo	61.34	0.00e+00	941.00
IUUC-Mmr-061233	Microcebus murinus	88.16	0.00e+00	1403.00
IUUC-Mdo-062446	Monodelphis domestica	77.60	0.00e+00	1249.00
IUUC-Mmu-063436	Mus musculus	85.98	0.00e+00	1380.00
IUUC-Mpu-066808	Mustela putorius furo	88.26	0.00e+00	1446.00
IUUC-Mlu-067339	Myotis lucifugus	87.47	0.00e+00	1425.00
IUUC-Nle-069888	Nomascus leucogenys	89.65	0.00e+00	1467.00
IUUC-Opr-070303	Ochotona princeps	86.29	0.00e+00	1390.00
IUUC-Ont-072283	Oreochromis niloticus	57.97	3.00e-143	502.00
IUUC-Oan-072925	Ornithorhynchus anatinus	74.72	0.00e+00	1209.00
IUUC-Ocu-073889	Oryctolagus cuniculus	87.89	0.00e+00	1387.00
IUUC-Ola-087417	Oryzias latipes	58.35	2.00e-146	513.00
IUUC-Oga-088708	Otolemur garnettii	87.09	0.00e+00	1353.00
IUUC-Oar-089271	Ovis aries	85.59	0.00e+00	1363.00
IUUC-Ptr-091296	Pan troglodytes	89.65	0.00e+00	1466.00
IUUC-Pan-092474	Papio anubis	90.03	0.00e+00	1473.00
IUUC-Psi-093447	Pelodiscus sinensis	67.71	0.00e+00	1087.00
IUUC-Pfo-096511	Poecilia formosa	58.45	5.00e-145	508.00
IUUC-Pab-098700	Pongo abelii	89.65	0.00e+00	1465.00
IUUC-Pca-100246	Procavia capensis	74.49	0.00e+00	1150.00
IUUC-Pva-102606	Pteropus vampyrus	76.46	2.00e-175	609.00
IUUC-Rno-105818	Rattus norvegicus	86.38	0.00e+00	1403.00
IUUC-Sha-106559	Sarcophilus harrisii	77.47	0.00e+00	1241.00
IUUC-Sar-113454	Sorex araneus	92.40	0.00e+00	635.00
IUUC-Ssc-116064	Sus scrofa	86.49	0.00e+00	1370.00
IUUC-Tgu-117212	Taeniopygia guttata	63.54	0.00e+00	1014.00
IUUC-Tru-118230	Takifugu rubripes	58.94	1.00e-147	517.00
IUUC-Tsy-119066	Tarsius syrichta	86.36	0.00e+00	1401.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.19	0.00e+00	665.00
IUUC-Tbe-127601	Tupaia belangeri	95.74	0.00e+00	662.00
IUUC-Ttr-128930	Tursiops truncatus	85.84	0.00e+00	1393.00
IUUC-Vpa-130450	Vicugna pacos	93.53	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence