iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089271

Ensembl Protein ID

ENSOARP00000000580.1

UniProt Accession

W5NQZ0; W5NQZ0_SHEEP

Genbank Protein ID

ENSOARP00000000580

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01107926

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000569.1	ENSOART00000000610.1	ENSOARP00000000580.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.90e-39	135.4	93	263
UBD/ZnF/ZnF_A20	3.70e-23	81.3	752	785

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++ l+++L+e+ ++++    q es + +ef+e++         de++++ k+++ +   
   Q: 93   VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKVLFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwTDEWDNLVKMASADtpa 181
           789**********************************************9**********************9**********999775 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
           a+g       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv++
   Q: 182  ARGglqyhslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVTM 263
           5557***************************************************************************986 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+ ++C++ +C+++Gn ++ngyC++C++++++++
   Q: 752  PPTQRCRApACDHFGNTKCNGYCNECFQFKQMYG 785
           99******************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAEQLLPLAL YLSNMRKAVK IRERTPADIF KPTNGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHNALID RNIQASLESQ KKLNWCREVR RLVALKTNGD GNCLMHAASQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATGATTT TCTGCAGAAA AACGGCTGAG AAAAAGAACC TATTTCATTT CCAGTTCCCA 60
TCACTGCGAT TTCCACATGG ATGTGACGTT CAGTCCAGCT TCCGAAATGC CCAGTTGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

oas:101113156

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	87.85	0.00e+00	1442.00
IUUC-Apl-003501	Anas platyrhynchos	64.94	0.00e+00	1022.00
IUUC-Aca-004245	Anolis carolinensis	62.70	0.00e+00	1034.00
IUUC-Ame-011789	Astyanax mexicanus	46.41	0.00e+00	694.00
IUUC-Bta-012664	Bos taurus	96.82	0.00e+00	1521.00
IUUC-Cja-019895	Callithrix jacchus	85.95	0.00e+00	1410.00
IUUC-Cfa-020754	Canis familiaris	88.23	0.00e+00	1447.00
IUUC-Cpo-021780	Cavia porcellus	85.59	0.00e+00	1394.00
IUUC-Csa-023568	Chlorocebus sabaeus	86.58	0.00e+00	1429.00
IUUC-Cho-024300	Choloepus hoffmanni	88.05	0.00e+00	642.00
IUUC-Dre-028577	Danio rerio	48.13	0.00e+00	682.00
IUUC-Dno-029382	Dasypus novemcinctus	80.15	0.00e+00	1286.00
IUUC-Dor-030874	Dipodomys ordii	82.78	0.00e+00	1335.00
IUUC-Ete-032721	Echinops telfairi	89.95	0.00e+00	797.00
IUUC-Eca-033596	Equus caballus	84.18	0.00e+00	1368.00
IUUC-Eeu-035159	Erinaceus europaeus	82.64	0.00e+00	1060.00
IUUC-Fca-035847	Felis catus	87.72	0.00e+00	1434.00
IUUC-Fal-036681	Ficedula albicollis	63.28	0.00e+00	1025.00
IUUC-Gmo-038521	Gadus morhua	59.71	1.00e-145	510.00
IUUC-Gga-040975	Gallus gallus	62.84	0.00e+00	1032.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.26	2.00e-151	529.00
IUUC-Ggo-045258	Gorilla gorilla	85.95	0.00e+00	1418.00
IUUC-Hsa-046071	Homo sapiens	85.82	0.00e+00	1418.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	86.71	0.00e+00	1409.00
IUUC-Lch-050326	Latimeria chalumnae	57.29	0.00e+00	897.00
IUUC-Loc-051945	Lepisosteus oculatus	47.03	5.00e-176	611.00
IUUC-Laf-053722	Loxodonta africana	84.30	0.00e+00	1382.00
IUUC-Mcc-055503	Macaca mulatta	86.33	0.00e+00	1424.00
IUUC-Meu-056481	Macropus eugenii	72.47	0.00e+00	1131.00
IUUC-Mga-059690	Meleagris gallopavo	61.47	0.00e+00	962.00
IUUC-Mmr-061233	Microcebus murinus	85.23	0.00e+00	1380.00
IUUC-Mdo-062446	Monodelphis domestica	77.92	0.00e+00	1250.00
IUUC-Mmu-063436	Mus musculus	85.35	0.00e+00	1355.00
IUUC-Mpu-066808	Mustela putorius furo	87.72	0.00e+00	1438.00
IUUC-Mlu-067339	Myotis lucifugus	86.58	0.00e+00	1404.00
IUUC-Nle-069888	Nomascus leucogenys	85.95	0.00e+00	1420.00
IUUC-Opr-070303	Ochotona princeps	84.62	0.00e+00	1376.00
IUUC-Ont-072283	Oreochromis niloticus	59.32	1.00e-146	514.00
IUUC-Oan-072925	Ornithorhynchus anatinus	75.06	0.00e+00	1209.00
IUUC-Ocu-073889	Oryctolagus cuniculus	86.09	0.00e+00	1377.00
IUUC-Ola-087417	Oryzias latipes	60.05	1.00e-147	517.00
IUUC-Oga-088708	Otolemur garnettii	83.80	0.00e+00	1317.00
IUUC-Ptr-091296	Pan troglodytes	85.82	0.00e+00	1417.00
IUUC-Pan-092474	Papio anubis	86.46	0.00e+00	1425.00
IUUC-Psi-093447	Pelodiscus sinensis	66.67	0.00e+00	1075.00
IUUC-Pfo-096511	Poecilia formosa	60.05	3.00e-148	519.00
IUUC-Pab-098700	Pongo abelii	85.95	0.00e+00	1418.00
IUUC-Pca-100246	Procavia capensis	72.15	0.00e+00	1142.00
IUUC-Pva-102606	Pteropus vampyrus	76.40	6.00e-177	614.00
IUUC-Rno-105818	Rattus norvegicus	84.99	0.00e+00	1385.00
IUUC-Sha-106559	Sarcophilus harrisii	77.05	0.00e+00	1234.00
IUUC-Sar-113454	Sorex araneus	91.46	0.00e+00	637.00
IUUC-Ssc-116064	Sus scrofa	91.34	0.00e+00	1456.00
IUUC-Tgu-117212	Taeniopygia guttata	63.67	0.00e+00	1025.00
IUUC-Tru-118230	Takifugu rubripes	60.05	3.00e-150	525.00
IUUC-Tsy-119066	Tarsius syrichta	83.86	0.00e+00	1370.00
IUUC-Tni-119825	Tetraodon nigroviridis	48.05	0.00e+00	679.00
IUUC-Tvi-122463	Trichoderma virens	42.86	1.40e+00	28.50
IUUC-Tbe-127601	Tupaia belangeri	94.82	0.00e+00	663.00
IUUC-Ttr-128930	Tursiops truncatus	91.72	0.00e+00	1471.00
IUUC-Vpa-130450	Vicugna pacos	95.51	0.00e+00	806.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence