iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036229

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02157840

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000001645.3	ENSFCAT00000001646.3	ENSFCAP00000001526.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.40e-39	134.3	388	696

Active Site

Position(s)	Description	Evidence
666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v+E+   g +++G+++efl+ll+++l+n+      ++ + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 388  YTIEVAYVNENdnfGREHPGSKQEFLSLLMQHLENSP----IFEGSLSKNLSLNSQAL-----KENLYYEAGKILAISLVHGGPSPGFF 467
           678999***98888**********************9....35777888888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + ++  ++  ++ ++ +dl++      ++e++++  + g+ +    +++k++  k+++ y
   Q: 468  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQMIIRV--NTATTVADLNSI-----VNECYNYLELIGCLRLITSISDKYMLAKDILVY 546
           ***********8...************9988888774..566666777765.....88899**999*********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e   ++++++ e++++e l++   ++  + ++ + +  Fw+ + +++++ + +  ++  
   Q: 547  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFYSIFCHKPENLSAEILSDL--FTVRTLSNVQSL-GFWNSYlQAVEDGKSAVTMEdi 632
           **************************************************95..555556666665.7888764666666665544455 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg++++P++Gf++ + ++ +++      ++P  n+C n+L LP  +++++++e++ +Ai++t ++e
   Q: 633  liFATGCNSIPPAGFKPTP-SIECLHM-----DFPVGNKCNNCLALPITNTYQEFQENMDFAIKNTLRLE 696
           55****************9.9999999.....*********************************87665 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MNENKPGASQ NLACVFCRKN DDCPNKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLVEDIR KEVNRASKLK CCICKKTGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGAAGTGG ACGAATTTGA ATCCTGTGGG CCGTTGGATG CGGCTGCTCG AGGTCAGCTT 60
TGCGGCTCTG CGAAAGAAGG GAAAACTGAT ACGACCGCTC TGGAACTTCT GCCCAGCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

fca:101086236

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	95.61	0.00e+00	1429.00
IUUC-Apl-003763	Anas platyrhynchos	59.89	0.00e+00	861.00
IUUC-Aca-004328	Anolis carolinensis	60.37	0.00e+00	865.00
IUUC-Ame-011288	Astyanax mexicanus	40.93	2.00e-168	585.00
IUUC-Bta-012496	Bos taurus	88.92	0.00e+00	1326.00
IUUC-Cja-019756	Callithrix jacchus	89.35	0.00e+00	1338.00
IUUC-Cfa-020806	Canis familiaris	95.18	0.00e+00	1423.00
IUUC-Cpo-022519	Cavia porcellus	86.69	0.00e+00	1290.00
IUUC-Csa-023957	Chlorocebus sabaeus	90.93	0.00e+00	1368.00
IUUC-Cho-024375	Choloepus hoffmanni	83.26	0.00e+00	1199.00
IUUC-Cin-025325	Ciona intestinalis	41.89	8.00e-68	249.00
IUUC-Csv-026262	Ciona savignyi	41.98	7.00e-68	250.00
IUUC-Dre-027829	Danio rerio	41.12	1.00e-157	549.00
IUUC-Dno-029362	Dasypus novemcinctus	89.53	0.00e+00	1327.00
IUUC-Dor-030710	Dipodomys ordii	82.86	0.00e+00	1260.00
IUUC-Dse-031248	Dothistroma septosporum	35.85	3.00e-03	37.40
IUUC-Dme-031692	Drosophila melanogaster	34.53	4.00e-42	166.00
IUUC-Ete-032282	Echinops telfairi	79.15	0.00e+00	1144.00
IUUC-Eca-033963	Equus caballus	92.35	0.00e+00	1385.00
IUUC-Eeu-035029	Erinaceus europaeus	87.23	0.00e+00	1311.00
IUUC-Fal-037015	Ficedula albicollis	57.82	0.00e+00	868.00
IUUC-Gmo-039715	Gadus morhua	41.51	5.00e-82	297.00
IUUC-Gga-040298	Gallus gallus	58.51	0.00e+00	896.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.20	5.00e-145	508.00
IUUC-Ggo-045456	Gorilla gorilla	90.37	0.00e+00	1356.00
IUUC-Hsa-046297	Homo sapiens	90.65	0.00e+00	1365.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.67	0.00e+00	930.00
IUUC-Lch-050287	Latimeria chalumnae	66.54	6.00e-106	378.00
IUUC-Loc-052839	Lepisosteus oculatus	55.96	5.00e-32	129.00
IUUC-Laf-053581	Loxodonta africana	87.72	0.00e+00	1300.00
IUUC-Mcc-055615	Macaca mulatta	90.65	0.00e+00	1365.00
IUUC-Meu-056753	Macropus eugenii	48.47	2.00e-128	453.00
IUUC-Mga-059902	Meleagris gallopavo	58.50	0.00e+00	899.00
IUUC-Mmr-061522	Microcebus murinus	92.07	0.00e+00	1374.00
IUUC-Mdo-063022	Monodelphis domestica	65.27	0.00e+00	905.00
IUUC-Mmu-063609	Mus musculus	76.07	0.00e+00	1173.00
IUUC-Mpu-066656	Mustela putorius furo	95.75	0.00e+00	1434.00
IUUC-Mlu-067011	Myotis lucifugus	91.50	0.00e+00	1347.00
IUUC-Nle-069949	Nomascus leucogenys	90.37	0.00e+00	1359.00
IUUC-Opr-071224	Ochotona princeps	82.71	2.00e-131	463.00
IUUC-Ont-072174	Oreochromis niloticus	36.78	7.00e-139	487.00
IUUC-Oan-072712	Ornithorhynchus anatinus	67.29	0.00e+00	976.00
IUUC-Ocu-073776	Oryctolagus cuniculus	89.94	0.00e+00	1345.00
IUUC-Ola-087247	Oryzias latipes	37.68	1.00e-131	463.00
IUUC-Oga-088094	Otolemur garnettii	87.42	0.00e+00	1236.00
IUUC-Oar-090248	Ovis aries	89.35	0.00e+00	1324.00
IUUC-Ptr-090634	Pan troglodytes	90.51	0.00e+00	1362.00
IUUC-Pan-092876	Papio anubis	90.79	0.00e+00	1367.00
IUUC-Psi-093580	Pelodiscus sinensis	60.69	0.00e+00	885.00
IUUC-Pma-094295	Petromyzon marinus	52.96	8.00e-73	266.00
IUUC-Pfo-096351	Poecilia formosa	37.31	3.00e-148	518.00
IUUC-Pab-097596	Pongo abelii	91.22	0.00e+00	1369.00
IUUC-Pca-100309	Procavia capensis	81.30	0.00e+00	1209.00
IUUC-Pva-102526	Pteropus vampyrus	94.75	0.00e+00	877.00
IUUC-Rno-105432	Rattus norvegicus	80.40	0.00e+00	1216.00
IUUC-Sha-107089	Sarcophilus harrisii	65.33	0.00e+00	1021.00
IUUC-Sar-113667	Sorex araneus	68.04	0.00e+00	979.00
IUUC-Ssc-116200	Sus scrofa	92.78	0.00e+00	1380.00
IUUC-Tgu-116467	Taeniopygia guttata	57.63	0.00e+00	859.00
IUUC-Tru-117690	Takifugu rubripes	39.12	2.00e-156	545.00
IUUC-Tsy-119481	Tarsius syrichta	88.20	0.00e+00	925.00
IUUC-Tni-119669	Tetraodon nigroviridis	38.14	2.00e-137	482.00
IUUC-Tbe-127241	Tupaia belangeri	81.96	0.00e+00	1175.00
IUUC-Ttr-129057	Tursiops truncatus	83.85	0.00e+00	1199.00
IUUC-Vpa-130685	Vicugna pacos	90.33	0.00e+00	1309.00
IUUC-Xtr-132555	Xenopus tropicalis	51.95	0.00e+00	747.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence