iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000006075.2	ENSPPYT00000033735.1	ENSPPYP00000024473.1
ENSPPYG00000006075.2	ENSPPYT00000007181.1	ENSPPYP00000006907.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UIM	3.10e-09	35.9	194	212
UBD/Alpha-Helix/UIM	8.7e-06	16.4	214	230
UBD/Alpha-Helix/UIM	8.1e-05	13.4	305	321

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +++e+Lq+AlalS+qE ++
   Q: 194  EDEEDLQRALALSRQEIDM 212
           69**************886 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           dE+++L++A++lS+q  
   Q: 214  DEEADLRRAIQLSMQGS 230
           7*************976 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           +E+++Lq A+++Sl+ +
   Q: 305  SEEDMLQAAVTMSLETV 321
           7*************986 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MESIFHEKQL EEEERMRMAE GGVSSEVFRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE 60
LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTCCA TCTTCCACGA GAAAGTGAGT GTCCGCGTTC GGTGGGGAGC CGTCTGCCGC 60
GCGGTGGCGG GCGTGGAGCG CGGTATCACC GCCTCCCGGA GGGCTGGGTG GGGCCGGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR009068--S15_NS1_RNA-bd
IPR011990--TPR-like_helical_dom
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN
PS50330--UIM

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin
SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030036--P:actin cytoskeleton organization
GO:0045104--P:intermediate filament cytoskeleton organization
GO:0000226--P:microtubule cytoskeleton organization
GO:1904294--P:positive regulation of ERAD pathway
GO:1904379--P:protein localization to cytosolic proteasome complex involved in ERAD pathway
GO:0010810--P:regulation of cell-substrate adhesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	90.63	3.00e-161	560.00
IUUC-Apl-003210	Anas platyrhynchos	73.37	2.00e-121	428.00
IUUC-Aca-005171	Anolis carolinensis	72.89	2.00e-123	435.00
IUUC-Afu-009069	Aspergillus fumigatus	26.89	1.60e-01	29.30
IUUC-Bta-013538	Bos taurus	80.92	2.00e-148	518.00
IUUC-Bci-013745	Botrytis cinerea	34.85	1.60e-01	31.60
IUUC-Cja-018840	Callithrix jacchus	84.73	7.00e-152	530.00
IUUC-Cfa-021035	Canis familiaris	91.82	1.00e-159	555.00
IUUC-Cpo-021776	Cavia porcellus	84.80	6.00e-156	543.00
IUUC-Cho-024878	Choloepus hoffmanni	91.29	3.00e-159	554.00
IUUC-Cgl-026754	Colletotrichum gloeosporioides	55.56	3.90e-01	30.80
IUUC-Dre-027506	Danio rerio	68.60	4.00e-86	310.00
IUUC-Dno-029172	Dasypus novemcinctus	91.27	3.00e-159	553.00
IUUC-Dor-030900	Dipodomys ordii	75.41	2.00e-118	418.00
IUUC-Ete-033000	Echinops telfairi	57.53	2.00e-80	291.00
IUUC-Eca-034338	Equus caballus	92.15	2.00e-161	561.00
IUUC-Eeu-034585	Erinaceus europaeus	98.10	2.00e-57	215.00
IUUC-Fca-035441	Felis catus	91.49	1.00e-72	264.00
IUUC-Fal-037525	Ficedula albicollis	71.74	1.00e-107	382.00
IUUC-Gga-040774	Gallus gallus	73.15	2.00e-122	431.00
IUUC-Ggo-044759	Gorilla gorilla	88.63	4.00e-152	530.00
IUUC-Hsa-046591	Homo sapiens	92.77	9.00e-154	536.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	72.90	3.00e-105	374.00
IUUC-Lch-049519	Latimeria chalumnae	69.83	5.00e-108	383.00
IUUC-Laf-053784	Loxodonta africana	86.71	7.00e-156	542.00
IUUC-Mcc-055283	Macaca mulatta	95.77	1.00e-170	592.00
IUUC-Meu-056589	Macropus eugenii	72.70	1.00e-124	439.00
IUUC-Mga-059301	Meleagris gallopavo	71.52	2.00e-124	438.00
IUUC-Mmr-061038	Microcebus murinus	92.24	3.00e-162	563.00
IUUC-Mdo-062927	Monodelphis domestica	76.90	1.00e-119	422.00
IUUC-Mmu-063600	Mus musculus	80.72	1.00e-132	465.00
IUUC-Mpu-065897	Mustela putorius furo	92.72	9.00e-133	466.00
IUUC-Mlu-067543	Myotis lucifugus	91.54	6.00e-133	466.00
IUUC-Nle-069847	Nomascus leucogenys	89.39	2.00e-153	535.00
IUUC-Opr-070550	Ochotona princeps	81.57	3.00e-136	477.00
IUUC-Ont-071723	Oreochromis niloticus	64.84	1.00e-87	316.00
IUUC-Oan-073569	Ornithorhynchus anatinus	75.15	1.00e-129	456.00
IUUC-Ocu-074632	Oryctolagus cuniculus	86.49	9.00e-156	542.00
IUUC-Ola-087566	Oryzias latipes	70.09	4.00e-89	320.00
IUUC-Oga-088617	Otolemur garnettii	70.65	7.00e-104	369.00
IUUC-Oar-090052	Ovis aries	84.75	5.00e-151	526.00
IUUC-Ptr-091435	Pan troglodytes	96.37	8.00e-172	595.00
IUUC-Pno-095003	Phaeosphaeria nodorum	34.52	6.50e-02	33.10
IUUC-Pva-102844	Pteropus vampyrus	91.84	7.00e-160	556.00
IUUC-Rno-104896	Rattus norvegicus	81.33	5.00e-142	496.00
IUUC-Sha-107106	Sarcophilus harrisii	80.83	2.00e-141	495.00
IUUC-Sly-111416	Solanum lycopersicum	39.13	5.00e-18	84.30
IUUC-Stu-112227	Solanum tuberosum	34.13	2.00e-20	92.40
IUUC-Sar-113534	Sorex araneus	77.42	1.00e-129	456.00
IUUC-Ssc-115274	Sus scrofa	90.03	3.00e-161	560.00
IUUC-Tgu-117426	Taeniopygia guttata	74.60	1.00e-119	422.00
IUUC-Tbe-127638	Tupaia belangeri	85.84	1.00e-145	508.00
IUUC-Ttr-129288	Tursiops truncatus	80.06	2.00e-133	468.00
IUUC-Vpa-130788	Vicugna pacos	90.75	5.00e-161	560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence