iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065716

Ensembl Protein ID

ENSMPUP00000012674.1

UniProt Accession

M3YMW7; M3YMW7_MUSPF

Genbank Protein ID

ENSMPUP00000012674

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01000408

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000012769.1	ENSMPUT00000012878.1	ENSMPUP00000012674.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-58	191.2	426	460
UBD/Beta-Prp	7.30e-69	232.2	339	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 426  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 460
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 339  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 422
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 423  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 504
           ***************9..***********************************99.************..99**************7 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

ASLCRKHKNQ KLMHSQVMED QNEDESPKKN TLWQISNGTS SVIVSRKRPS EGNYQKEKDL 60
CIKYFDQWSE SDQVEFVEHL ISRMCHYQHG HINSYLKPML QRDFITALPE QGLDHIAENI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCTTTGT GCAGGAAACA CAAAAATCAA AAGCTAATGC ATTCTCAAGG CAAGCCAGAT 60
TGTTACTGGC TACCAGCATC CTCCTCTTCA GGGAAAAAGT TGGGGCACAC ACCATGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	100.00	0.00e+00	1022.00
IUUC-Apl-003449	Anas platyrhynchos	98.65	0.00e+00	1053.00
IUUC-Aca-004341	Anolis carolinensis	99.10	0.00e+00	913.00
IUUC-Ani-009324	Aspergillus nidulans	29.65	1.00e-47	184.00
IUUC-Ang-009766	Aspergillus niger	31.41	5.00e-52	199.00
IUUC-Ate-010546	Aspergillus terreus	36.21	1.00e-42	168.00
IUUC-Ame-011393	Astyanax mexicanus	89.23	0.00e+00	962.00
IUUC-Bta-012920	Bos taurus	99.03	0.00e+00	1060.00
IUUC-Bci-013685	Botrytis cinerea	30.72	6.00e-54	205.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	635.00
IUUC-Cja-018879	Callithrix jacchus	100.00	0.00e+00	1022.00
IUUC-Cfa-020021	Canis familiaris	100.00	0.00e+00	1022.00
IUUC-Cpo-022151	Cavia porcellus	99.03	0.00e+00	1051.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1056.00
IUUC-Cho-024658	Choloepus hoffmanni	99.53	9.00e-127	446.00
IUUC-Cin-025188	Ciona intestinalis	80.42	0.00e+00	824.00
IUUC-Csv-026020	Ciona savignyi	78.75	0.00e+00	781.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.12	4.00e-59	223.00
IUUC-Dre-028160	Danio rerio	88.97	0.00e+00	962.00
IUUC-Dno-029485	Dasypus novemcinctus	88.80	0.00e+00	927.00
IUUC-Dor-030498	Dipodomys ordii	99.60	0.00e+00	1016.00
IUUC-Dse-031287	Dothistroma septosporum	28.95	1.00e-52	201.00
IUUC-Dme-031885	Drosophila melanogaster	80.84	0.00e+00	811.00
IUUC-Eca-033804	Equus caballus	100.00	0.00e+00	1022.00
IUUC-Fca-035887	Felis catus	98.85	0.00e+00	1066.00
IUUC-Fal-036783	Ficedula albicollis	98.84	0.00e+00	1058.00
IUUC-Fox-037978	Fusarium oxysporum	33.56	1.00e-60	227.00
IUUC-Fso-038077	Fusarium solani	32.52	1.00e-55	211.00
IUUC-Gmo-038590	Gadus morhua	91.30	0.00e+00	929.00
IUUC-Ggr-039974	Gaeumannomyces graminis	31.72	7.00e-55	209.00
IUUC-Gga-040628	Gallus gallus	98.45	0.00e+00	1053.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.89	0.00e+00	932.00
IUUC-Ggo-044604	Gorilla gorilla	100.00	0.00e+00	1022.00
IUUC-Hsa-046139	Homo sapiens	100.00	0.00e+00	1022.00
IUUC-Lch-050460	Latimeria chalumnae	95.57	0.00e+00	1033.00
IUUC-Lma-053289	Leptosphaeria maculans	37.72	1.00e-45	178.00
IUUC-Laf-053968	Loxodonta africana	99.22	0.00e+00	1061.00
IUUC-Mcc-055822	Macaca mulatta	96.05	0.00e+00	1049.00
IUUC-Mor-057283	Magnaporthe oryzae	32.52	2.00e-56	214.00
IUUC-Mpo-057540	Magnaporthe poae	31.94	3.00e-55	210.00
IUUC-Mla-058989	Melampsora laricipopulina	40.57	6.00e-60	224.00
IUUC-Mga-059225	Meleagris gallopavo	98.45	0.00e+00	1045.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	1.00e-69	258.00
IUUC-Mmr-060746	Microcebus murinus	100.00	0.00e+00	1022.00
IUUC-Mdo-062005	Monodelphis domestica	99.41	0.00e+00	1052.00
IUUC-Mmu-063851	Mus musculus	98.45	0.00e+00	1055.00
IUUC-Mlu-067001	Myotis lucifugus	100.00	0.00e+00	1056.00
IUUC-Nle-069788	Nomascus leucogenys	100.00	0.00e+00	1022.00
IUUC-Opr-071229	Ochotona princeps	99.80	0.00e+00	1021.00
IUUC-Ont-071792	Oreochromis niloticus	91.50	0.00e+00	940.00
IUUC-Oan-072782	Ornithorhynchus anatinus	98.84	0.00e+00	1058.00
IUUC-Ocu-074894	Oryctolagus cuniculus	99.22	0.00e+00	1061.00
IUUC-Ola-086985	Oryzias latipes	89.06	0.00e+00	957.00
IUUC-Oga-088604	Otolemur garnettii	93.43	0.00e+00	1045.00
IUUC-Oar-090412	Ovis aries	99.22	0.00e+00	1062.00
IUUC-Ptr-091039	Pan troglodytes	99.80	0.00e+00	1021.00
IUUC-Pan-092770	Papio anubis	99.19	0.00e+00	1013.00
IUUC-Psi-093887	Pelodiscus sinensis	98.06	0.00e+00	1048.00
IUUC-Pma-094315	Petromyzon marinus	83.43	0.00e+00	847.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	90.29	0.00e+00	960.00
IUUC-Pva-102547	Pteropus vampyrus	99.80	0.00e+00	1015.00
IUUC-Ptt-103853	Puccinia triticina	32.75	3.00e-60	226.00
IUUC-Rno-105246	Rattus norvegicus	98.45	0.00e+00	1055.00
IUUC-Sha-107339	Sarcophilus harrisii	99.41	0.00e+00	1052.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	4.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.42	2.00e-66	246.00
IUUC-Sre-114916	Sporisorium reilianum	31.64	9.00e-43	169.00
IUUC-Tgu-116541	Taeniopygia guttata	98.64	0.00e+00	1053.00
IUUC-Tru-117671	Takifugu rubripes	89.65	0.00e+00	949.00
IUUC-Tni-120359	Tetraodon nigroviridis	88.89	0.00e+00	951.00
IUUC-Tre-122207	Trichoderma reesei	32.97	2.00e-53	204.00
IUUC-Tvi-122344	Trichoderma virens	32.97	2.00e-54	206.00
IUUC-Tme-127141	Tuber melanosporum	33.33	4.00e-62	232.00
IUUC-Tbe-127418	Tupaia belangeri	93.32	0.00e+00	936.00
IUUC-Ttr-129131	Tursiops truncatus	100.00	0.00e+00	1022.00
IUUC-Vpa-130668	Vicugna pacos	100.00	0.00e+00	1023.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	6.00e-158	549.00
IUUC-Yli-134582	Yarrowia lipolytica	34.99	6.00e-56	211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence