iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132090

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01017743

Gene Name

usp49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000011843.3	ENSXETT00000025887.3	ENSXETP00000025887.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.20e-99	331.0	256	644

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp..........................................ke 44
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+   +   + +e                                             ++
   Q: 256  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldpS---EKEELLArtgtngkrrvgdaggghpvggiglnggssitksleliqpkepST 341
           7******************************5552...333322245567888899999999999999999999999999988888788 PP
   S: 45   pkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeek 133
           ++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         e+e+++++ l  ++++k
   Q: 342  KHLSLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL---------ESEGSKRRILIPISQRK 421
           888************************************************************.........67899999999****** PP
   S: 134  kkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyycekck 212
            +k+  ++++++F+gql sq++cl+c  +s + epf+dlsl++p++ +++++          +l+++L++ft++e leg+  y c++c+
   Q: 422  LTKQVLKVVNTIFHGQLLSQVTCLKCSYKSDTVEPFWDLSLEFPERYHSQEKgiapvtttecTLTEMLAKFTETEALEGRI-YACDQCN 509
           ***********************************************98888**************************965.******* PP
   S: 213  kkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...peekqkekkkYeLiavvvHs 287
           +k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c s   p++   e + Y+L+avv+H+
   Q: 510  SKRRksspkplvlseAKKQLMIFRLPQVLRLHLKRFRWSGR-NHREKIGVHVFFDQVLNMEPYCRSvlpPSNP--EAYLYDLSAVVMHH 595
           9999999*******************************997.8889******************997744433..39************ PP
   S: 288  G.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           G +++sGHY+ay++n++g+ W++++Dsk + ++ eev++   ++aY+lfY++
   Q: 596  GkGFGSGHYTAYCYNTEGGfWVHCNDSKLNMCSVEEVCR---TQAYILFYTQ 644
           ***************9999********************...********98 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWRCVDCD TKESVWACLK CSHVACGRYI EEHSLRHFQE 60
SSHPLVMEVH ELYVFCYLCQ DYVLNDNPEG DLKLLRSALS AVWTQKQEAY SRRSLRSQVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCGAT GTAAGCATGT TGGACGCCTG CGCCTTGCAC AGGATCATTC TATTCTAAAC 60
CCACAAAAGT GGCGTTGTGT AGACTGTGAC ACAAAAGAGT CTGTGTGGGC ATGCCTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination

KEGG

xtr:100488823

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	75.14	0.00e+00	1027.00
IUUC-Aca-005278	Anolis carolinensis	74.86	0.00e+00	1043.00
IUUC-Bta-012911	Bos taurus	70.35	0.00e+00	899.00
IUUC-Cja-019171	Callithrix jacchus	71.67	0.00e+00	932.00
IUUC-Cfa-020408	Canis familiaris	71.39	0.00e+00	914.00
IUUC-Cpo-022233	Cavia porcellus	67.67	0.00e+00	875.00
IUUC-Csa-024272	Chlorocebus sabaeus	72.70	0.00e+00	775.00
IUUC-Cho-025051	Choloepus hoffmanni	73.50	8.00e-149	520.00
IUUC-Cin-025587	Ciona intestinalis	47.86	2.00e-109	390.00
IUUC-Csv-025814	Ciona savignyi	42.88	2.00e-145	509.00
IUUC-Dre-027577	Danio rerio	66.32	0.00e+00	784.00
IUUC-Dno-029856	Dasypus novemcinctus	71.57	0.00e+00	931.00
IUUC-Eca-033851	Equus caballus	70.99	0.00e+00	857.00
IUUC-Fal-037290	Ficedula albicollis	75.25	0.00e+00	932.00
IUUC-Gmo-039249	Gadus morhua	79.25	2.00e-147	515.00
IUUC-Gac-042595	Gasterosteus aculeatus	63.78	0.00e+00	801.00
IUUC-Ggo-044979	Gorilla gorilla	72.04	0.00e+00	931.00
IUUC-Hsa-046743	Homo sapiens	71.75	0.00e+00	925.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	70.88	0.00e+00	932.00
IUUC-Lch-050294	Latimeria chalumnae	74.49	0.00e+00	944.00
IUUC-Loc-051961	Lepisosteus oculatus	71.28	0.00e+00	807.00
IUUC-Mcc-055048	Macaca mulatta	71.75	0.00e+00	929.00
IUUC-Meu-055971	Macropus eugenii	64.94	6.00e-147	514.00
IUUC-Mdo-062073	Monodelphis domestica	74.15	0.00e+00	1030.00
IUUC-Mmu-064095	Mus musculus	70.03	0.00e+00	927.00
IUUC-Mlu-067090	Myotis lucifugus	70.74	0.00e+00	910.00
IUUC-Nle-069486	Nomascus leucogenys	71.75	0.00e+00	926.00
IUUC-Opr-070563	Ochotona princeps	70.61	0.00e+00	919.00
IUUC-Ont-072103	Oreochromis niloticus	65.69	0.00e+00	815.00
IUUC-Ola-086413	Oryzias latipes	61.79	0.00e+00	747.00
IUUC-Oga-088862	Otolemur garnettii	70.45	0.00e+00	931.00
IUUC-Ptr-091525	Pan troglodytes	73.19	0.00e+00	851.00
IUUC-Pan-092363	Papio anubis	73.48	0.00e+00	920.00
IUUC-Psi-093353	Pelodiscus sinensis	76.30	0.00e+00	1044.00
IUUC-Pfo-096413	Poecilia formosa	64.60	0.00e+00	809.00
IUUC-Pca-100449	Procavia capensis	71.59	0.00e+00	946.00
IUUC-Pva-102868	Pteropus vampyrus	70.60	0.00e+00	909.00
IUUC-Rno-105190	Rattus norvegicus	70.20	0.00e+00	924.00
IUUC-Sha-107337	Sarcophilus harrisii	74.57	0.00e+00	1025.00
IUUC-Sar-113561	Sorex araneus	71.19	2.00e-70	259.00
IUUC-Ssc-115735	Sus scrofa	70.60	0.00e+00	897.00
IUUC-Tgu-117025	Taeniopygia guttata	71.35	0.00e+00	863.00
IUUC-Tru-117585	Takifugu rubripes	63.51	0.00e+00	789.00
IUUC-Tsy-118814	Tarsius syrichta	71.10	0.00e+00	919.00
IUUC-Tni-120600	Tetraodon nigroviridis	64.53	0.00e+00	754.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence