iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036467

Ensembl Protein ID

ENSFCAP00000019449.1

UniProt Accession

M3WYK9; M3WYK9_FELCA

Genbank Protein ID

ENSFCAP00000019449

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AANG02062383

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000028949.1	ENSFCAT00000024827.1	ENSFCAP00000019449.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.50e-09	36.1	227	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 227  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 273
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

AAAAAAARSS SGGRMLGQQQ QQLYSSAALL TGERSRLLTC YVQDYLECVE SLPHDMQRNV 60
SVLRELDNKY QETLKEIDDV YEKYKKEDDS NQKKRLQQHL QRALINSQEL GDEKIQIVTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGGCGG CGGCGGCGGC GAGGAGCAGC AGCGGCGGCA GGATGTTAGG GCAGCAGCAG 60
CAGCAACTAT ACTCGTCGGC CGCGCTCCTG ACCGGGGAGC GGAGCCGGCT CCTCACCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	99.64	6.00e-124	436.00
IUUC-Apl-003705	Anas platyrhynchos	88.79	7.00e-92	329.00
IUUC-Aca-004990	Anolis carolinensis	81.08	6.00e-98	350.00
IUUC-Ame-011426	Astyanax mexicanus	70.80	4.00e-84	304.00
IUUC-Bta-012721	Bos taurus	98.53	7.00e-121	426.00
IUUC-Cja-018960	Callithrix jacchus	98.11	1.00e-106	379.00
IUUC-Cfa-020869	Canis familiaris	99.29	9.00e-125	439.00
IUUC-Cpo-021414	Cavia porcellus	97.14	1.00e-120	425.00
IUUC-Csa-023304	Chlorocebus sabaeus	98.21	5.00e-113	400.00
IUUC-Cne-027005	Cryptococcus neoformans	48.48	8.00e-16	77.80
IUUC-Dre-028562	Danio rerio	69.00	2.00e-89	322.00
IUUC-Dno-029945	Dasypus novemcinctus	98.11	5.00e-116	410.00
IUUC-Dor-030141	Dipodomys ordii	96.79	1.00e-118	419.00
IUUC-Ete-032709	Echinops telfairi	95.41	5.00e-128	450.00
IUUC-Eca-033432	Equus caballus	98.90	1.00e-120	425.00
IUUC-Eeu-035285	Erinaceus europaeus	98.54	3.00e-91	327.00
IUUC-Fal-036700	Ficedula albicollis	87.56	4.00e-91	327.00
IUUC-Gmo-038748	Gadus morhua	62.68	5.00e-85	307.00
IUUC-Gga-040175	Gallus gallus	88.34	1.00e-91	328.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	7.00e-90	323.00
IUUC-Hsa-045837	Homo sapiens	98.21	5.00e-113	400.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	98.57	5.00e-122	430.00
IUUC-Lch-049965	Latimeria chalumnae	80.53	5.00e-100	357.00
IUUC-Laf-053353	Loxodonta africana	96.44	1.00e-100	358.00
IUUC-Mcc-055155	Macaca mulatta	98.28	5.00e-73	266.00
IUUC-Meu-056470	Macropus eugenii	92.91	4.00e-111	394.00
IUUC-Mga-059570	Meleagris gallopavo	88.34	4.00e-91	327.00
IUUC-Mmr-061385	Microcebus murinus	98.57	1.00e-113	402.00
IUUC-Mdo-062144	Monodelphis domestica	92.97	2.00e-112	398.00
IUUC-Mmu-063215	Mus musculus	96.80	8.00e-120	422.00
IUUC-Mpu-065749	Mustela putorius furo	99.16	1.00e-101	362.00
IUUC-Nle-069968	Nomascus leucogenys	97.89	1.00e-81	295.00
IUUC-Ont-071524	Oreochromis niloticus	65.93	9.00e-87	313.00
IUUC-Ocu-074870	Oryctolagus cuniculus	99.26	2.00e-121	428.00
IUUC-Ola-087400	Oryzias latipes	89.02	2.00e-44	171.00
IUUC-Oga-088336	Otolemur garnettii	97.21	4.00e-114	404.00
IUUC-Oar-090136	Ovis aries	98.15	4.00e-119	420.00
IUUC-Ptr-091348	Pan troglodytes	98.42	2.00e-82	298.00
IUUC-Pan-092819	Papio anubis	98.21	5.00e-113	400.00
IUUC-Pma-094265	Petromyzon marinus	72.22	9.00e-32	129.00
IUUC-Pfo-096633	Poecilia formosa	63.79	8.00e-81	293.00
IUUC-Pab-098346	Pongo abelii	98.21	6.00e-113	399.00
IUUC-Pca-100278	Procavia capensis	95.67	4.00e-117	413.00
IUUC-Pva-103190	Pteropus vampyrus	99.24	4.00e-117	413.00
IUUC-Rno-104940	Rattus norvegicus	96.97	2.00e-114	405.00
IUUC-Sha-107533	Sarcophilus harrisii	91.18	2.00e-113	401.00
IUUC-Sar-113630	Sorex araneus	97.56	1.00e-91	328.00
IUUC-Ssc-115734	Sus scrofa	99.24	7.00e-117	413.00
IUUC-Tgu-117034	Taeniopygia guttata	88.00	1.00e-91	328.00
IUUC-Tru-118168	Takifugu rubripes	60.34	2.00e-81	295.00
IUUC-Tsy-119494	Tarsius syrichta	98.95	6.00e-83	299.00
IUUC-Tni-120100	Tetraodon nigroviridis	60.52	2.00e-77	281.00
IUUC-Ttr-128442	Tursiops truncatus	98.54	3.00e-91	327.00
IUUC-Vpa-130063	Vicugna pacos	98.57	2.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence