iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033798

UUCD1 version

UUC-EqC-00749

Ensembl Protein ID

ENSECAP00000008967.1

UniProt Accession

F7BX08; F7BX08_HORSE

Protein Name

Uncharacterized protein

Gene Name

KLHL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000010727.1	ENSECAT00000011464.1	ENSECAP00000008967.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.90e-21	75.8	47	114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.30e-09	35.9	147	176

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv++v ++ e++ah++vLaa+S++F+a+f++e++es+  ++v ik+v+   +r l++++Yt +++ +e
   Q: 47   CDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESR-AKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 114
           8*************************************.*************************99765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
            Nclgi++fAd++ c+dL  +a+ ++++hF
   Q: 147  VNCLGIRAFADMHACTDLLNKANIYAEQHF 176
           6****************************9 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

CTKQGHQKPL DSKDDNIEKH CPVTVNPWHM KKAFKVMNEL RSQNLLCDVT IVAEDMEISA 60
HRVVLAACSP YFHAMFTGEM SESRAKRVRI KEVDGWTLRM LIDYVYTAEI QVTEENVQVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCACAAAGC AGGGTCATCA GAAGCCTCTC GATTCAAAAG ATGATAATAT TGAAAAACAC 60
TGCCCTGTGA CAGTGAATCC TTGGCATATG AAGAAAGCTT TTAAAGTCAT GAACGAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0003779--F:actin binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002378	Ailuropoda melanoleuca	98.63	0.00e+00	1159.00
IUUC-Apl-003260	Anas platyrhynchos	92.47	0.00e+00	1097.00
IUUC-Aca-005143	Anolis carolinensis	88.53	0.00e+00	1088.00
IUUC-Cja-018942	Callithrix jacchus	98.97	0.00e+00	1164.00
IUUC-Cfa-020886	Canis familiaris	98.97	0.00e+00	1165.00
IUUC-Cpo-022543	Cavia porcellus	99.14	0.00e+00	1166.00
IUUC-Csa-023088	Chlorocebus sabaeus	98.80	0.00e+00	1163.00
IUUC-Dre-028082	Danio rerio	81.34	0.00e+00	973.00
IUUC-Dno-029873	Dasypus novemcinctus	96.43	0.00e+00	1139.00
IUUC-Dor-030460	Dipodomys ordii	78.77	0.00e+00	855.00
IUUC-Dse-031229	Dothistroma septosporum	37.14	4.00e-08	51.20
IUUC-Dme-032172	Drosophila melanogaster	61.72	0.00e+00	670.00
IUUC-Eeu-034824	Erinaceus europaeus	90.79	0.00e+00	966.00
IUUC-Fca-036455	Felis catus	98.97	0.00e+00	1165.00
IUUC-Fal-037293	Ficedula albicollis	92.25	0.00e+00	1040.00
IUUC-Gmo-038811	Gadus morhua	78.85	0.00e+00	877.00
IUUC-Gga-040805	Gallus gallus	91.95	0.00e+00	1092.00
IUUC-Gac-041979	Gasterosteus aculeatus	81.12	0.00e+00	880.00
IUUC-Ggo-044620	Gorilla gorilla	94.01	0.00e+00	1102.00
IUUC-Hsa-046265	Homo sapiens	99.14	0.00e+00	1166.00
IUUC-Lch-049939	Latimeria chalumnae	83.90	0.00e+00	975.00
IUUC-Loc-052780	Lepisosteus oculatus	86.47	0.00e+00	1028.00
IUUC-Laf-053800	Loxodonta africana	98.80	0.00e+00	1161.00
IUUC-Mcc-055732	Macaca mulatta	97.77	0.00e+00	1150.00
IUUC-Meu-056011	Macropus eugenii	95.57	0.00e+00	1046.00
IUUC-Mmr-061067	Microcebus murinus	97.95	0.00e+00	1150.00
IUUC-Mdo-062977	Monodelphis domestica	95.21	0.00e+00	1130.00
IUUC-Mmu-064035	Mus musculus	98.61	0.00e+00	1145.00
IUUC-Mpu-066726	Mustela putorius furo	98.80	0.00e+00	1163.00
IUUC-Mlu-067020	Myotis lucifugus	98.29	0.00e+00	1157.00
IUUC-Nle-069456	Nomascus leucogenys	99.14	0.00e+00	1166.00
IUUC-Opr-071130	Ochotona princeps	89.21	0.00e+00	1022.00
IUUC-Ont-072219	Oreochromis niloticus	82.69	0.00e+00	929.00
IUUC-Oan-073699	Ornithorhynchus anatinus	94.09	0.00e+00	958.00
IUUC-Ocu-074045	Oryctolagus cuniculus	98.63	0.00e+00	1159.00
IUUC-Oga-088494	Otolemur garnettii	98.63	0.00e+00	1159.00
IUUC-Oar-089645	Ovis aries	98.63	0.00e+00	1160.00
IUUC-Ptr-091063	Pan troglodytes	99.14	0.00e+00	1166.00
IUUC-Pan-092273	Papio anubis	98.54	0.00e+00	949.00
IUUC-Psi-093946	Pelodiscus sinensis	91.47	0.00e+00	1103.00
IUUC-Pma-094177	Petromyzon marinus	74.51	0.00e+00	794.00
IUUC-Pfo-096817	Poecilia formosa	81.64	0.00e+00	942.00
IUUC-Pab-097768	Pongo abelii	98.97	0.00e+00	1164.00
IUUC-Pca-100607	Procavia capensis	82.35	0.00e+00	828.00
IUUC-Pva-102218	Pteropus vampyrus	92.98	0.00e+00	1078.00
IUUC-Rno-105250	Rattus norvegicus	98.80	0.00e+00	1160.00
IUUC-Sar-113249	Sorex araneus	97.91	0.00e+00	1137.00
IUUC-Ssc-115423	Sus scrofa	98.80	0.00e+00	1162.00
IUUC-Tgu-117050	Taeniopygia guttata	90.94	0.00e+00	1081.00
IUUC-Tru-118239	Takifugu rubripes	82.02	0.00e+00	976.00
IUUC-Tsy-119377	Tarsius syrichta	84.76	0.00e+00	1001.00
IUUC-Tni-120122	Tetraodon nigroviridis	80.65	0.00e+00	876.00
IUUC-Ttr-128574	Tursiops truncatus	98.52	0.00e+00	696.00
IUUC-Vpa-130707	Vicugna pacos	95.28	0.00e+00	878.00
IUUC-Xtr-132035	Xenopus tropicalis	86.50	0.00e+00	1048.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence