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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063874
UUCD1 version UUC-MuM-01187
Ensembl Protein ID ENSMUSP00000006854.7
UniProt Accession Q3UJD6; Q3TAC9; Q3TUE6; Q6P9T0; Q80TP5; Q80ZW5; UBP19_MOUSE
Genbank Protein ID BAC65678.4; BAE27219.1; BAE36025.1; BAE42739.1; AAH46824.1; AAH60613.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19
Genbank Nucleotide ID AK122396; AK146504; AK160807; AK171942; BC046824; BC060613
Gene Name Usp19; Kiaa0891
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006676.16 ENSMUST00000006854.12 ENSMUSP00000006854.7
ENSMUSG00000006676.16 ENSMUST00000166103.8 ENSMUSP00000128573.2
ENSMUSG00000006676.16 ENSMUST00000085044.13 ENSMUSP00000082119.7
ENSMUSG00000006676.16 ENSMUST00000193678.5 ENSMUSP00000141738.1
ENSMUSG00000006676.16 ENSMUST00000178075.7 ENSMUSP00000135930.1
ENSMUSG00000006676.16 ENSMUST00000193558.1 ENSMUSP00000142137.1
ENSMUSG00000006676.16 ENSMUST00000194171.5 ENSMUSP00000141628.1
ENSMUSG00000006676.16 ENSMUST00000194863.1 ENSMUSP00000141826.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 6.30e-115 385.1 539 1256
Active Site
Position(s) Description Evidence
548 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1207 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 539  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTG 625
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 626  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 710
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 711  FLYLPVPLPQKQKVLPIfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldavsptd 797
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 798  vllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqseeeklkrctrcyrvgycnqfcqkthwpdhkglcrpenigypf 884
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 885  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstssleagdserepiqpselqlvtpvaegdtgahrv 971
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 972  wppadrgpvpstsglssemlasgpiegcpllagervsrpeaavpgyqhssesvnthtpqffiykidasnreqrledkgetplelgdd 1058
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1059 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1145
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1146 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1229
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1230 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1256
           ****************...********996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains (By similarity). Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
 Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains (By similarity). Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
Protein Sequence
(Fasta)
MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT KDELLLDWRQ 60
SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW GGVFFAEIQS SCTKVQARKG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063874|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGGCCGAG CACCGGAACC CCTCCTCTTC CTTTCCCGCC CTCCCCAAAG CTGCCCTTCA 60
CCAAGAGCTC CCACTCTTGC CGGAAGTGCG TCATCAGCTC GGCACCCCGC CTCCCGTAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063874|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND
PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2
Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND
Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0051879--F:Hsp90 protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0090068--P:positive regulation of cell cycle process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0031647--P:regulation of protein stability
GO:0034976--P:response to endoplasmic reticulum stress
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:71472
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001999 Ailuropoda melanoleuca 88.15 0.00e+00 2216.00
IUUC-Apl-003368 Anas platyrhynchos 70.43 0.00e+00 1679.00
IUUC-Aca-004267 Anolis carolinensis 67.56 0.00e+00 1688.00
IUUC-Ame-010970 Astyanax mexicanus 70.74 0.00e+00 1338.00
IUUC-Bta-012905 Bos taurus 88.08 0.00e+00 2212.00
IUUC-Cja-018789 Callithrix jacchus 86.57 0.00e+00 2299.00
IUUC-Cfa-021004 Canis familiaris 92.35 0.00e+00 2169.00
IUUC-Cpo-021529 Cavia porcellus 89.55 0.00e+00 2294.00
IUUC-Csa-024035 Chlorocebus sabaeus 89.91 0.00e+00 2263.00
IUUC-Cho-025036 Choloepus hoffmanni 83.53 0.00e+00 1232.00
IUUC-Cin-025451 Ciona intestinalis 43.67 8.00e-87 315.00
IUUC-Csv-025931 Ciona savignyi 36.59 9.00e-112 397.00
IUUC-Dre-028556 Danio rerio 69.14 0.00e+00 1310.00
IUUC-Dno-029240 Dasypus novemcinctus 87.22 0.00e+00 2103.00
IUUC-Dor-030495 Dipodomys ordii 94.11 0.00e+00 1229.00
IUUC-Ete-032741 Echinops telfairi 90.57 0.00e+00 1821.00
IUUC-Eca-033661 Equus caballus 91.84 0.00e+00 2353.00
IUUC-Eeu-034648 Erinaceus europaeus 88.31 0.00e+00 785.00
IUUC-Fca-035646 Felis catus 87.97 0.00e+00 2184.00
IUUC-Fal-037094 Ficedula albicollis 68.07 0.00e+00 1788.00
IUUC-Gmo-038869 Gadus morhua 71.78 0.00e+00 844.00
IUUC-Gga-041170 Gallus gallus 65.61 0.00e+00 1728.00
IUUC-Gac-041901 Gasterosteus aculeatus 66.85 0.00e+00 1317.00
IUUC-Ggo-044708 Gorilla gorilla 86.65 0.00e+00 2311.00
IUUC-Hsa-046791 Homo sapiens 92.41 0.00e+00 1996.00
IUUC-Itr-048892 Ictidomys tridecemlineatus 87.43 0.00e+00 2265.00
IUUC-Lch-050456 Latimeria chalumnae 52.46 0.00e+00 1191.00
IUUC-Loc-052861 Lepisosteus oculatus 62.08 0.00e+00 1139.00
IUUC-Laf-053788 Loxodonta africana 90.76 0.00e+00 2257.00
IUUC-Mcc-055693 Macaca mulatta 85.44 0.00e+00 2230.00
IUUC-Meu-055921 Macropus eugenii 78.91 0.00e+00 1518.00
IUUC-Mga-059879 Meleagris gallopavo 68.62 0.00e+00 1725.00
IUUC-Mmr-060802 Microcebus murinus 88.87 0.00e+00 2337.00
IUUC-Mdo-061856 Monodelphis domestica 82.08 0.00e+00 1610.00
IUUC-Mpu-066166 Mustela putorius furo 92.09 0.00e+00 2141.00
IUUC-Nle-070161 Nomascus leucogenys 86.86 0.00e+00 2346.00
IUUC-Opr-071015 Ochotona princeps 91.03 0.00e+00 1878.00
IUUC-Ont-072308 Oreochromis niloticus 69.28 0.00e+00 1365.00
IUUC-Oan-072723 Ornithorhynchus anatinus 64.98 0.00e+00 1631.00
IUUC-Ocu-073938 Oryctolagus cuniculus 87.61 0.00e+00 2209.00
IUUC-Ola-086375 Oryzias latipes 71.33 0.00e+00 1335.00
IUUC-Oga-088297 Otolemur garnettii 87.47 0.00e+00 2257.00
IUUC-Oar-089675 Ovis aries 81.74 0.00e+00 1988.00
IUUC-Ptr-091621 Pan troglodytes 92.32 0.00e+00 1996.00
IUUC-Pan-092118 Papio anubis 86.21 0.00e+00 2251.00
IUUC-Pma-094154 Petromyzon marinus 51.31 1.00e-113 403.00
IUUC-Pfo-097246 Poecilia formosa 60.73 0.00e+00 1018.00
IUUC-Pab-098551 Pongo abelii 91.43 0.00e+00 1969.00
IUUC-Pca-100158 Procavia capensis 86.84 0.00e+00 2231.00
IUUC-Pva-103160 Pteropus vampyrus 91.55 0.00e+00 2296.00
IUUC-Rno-105355 Rattus norvegicus 95.37 0.00e+00 2475.00
IUUC-Sha-107057 Sarcophilus harrisii 76.43 0.00e+00 1781.00
IUUC-Sar-113011 Sorex araneus 87.62 0.00e+00 1450.00
IUUC-Ssc-115761 Sus scrofa 87.09 0.00e+00 2218.00
IUUC-Tgu-116956 Taeniopygia guttata 60.75 0.00e+00 817.00
IUUC-Tru-118739 Takifugu rubripes 67.72 0.00e+00 1344.00
IUUC-Tsy-118827 Tarsius syrichta 85.14 0.00e+00 1240.00
IUUC-Tni-119921 Tetraodon nigroviridis 60.59 0.00e+00 1422.00
IUUC-Tbe-128017 Tupaia belangeri 89.46 0.00e+00 1918.00
IUUC-Ttr-128869 Tursiops truncatus 91.54 0.00e+00 2307.00
IUUC-Uma-129498 Ustilago maydis 30.94 4.00e-87 317.00
IUUC-Vpa-130427 Vicugna pacos 92.74 0.00e+00 895.00
IUUC-Xtr-132734 Xenopus tropicalis 60.77 0.00e+00 1545.00
Created Date 25-Jun-2017

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