iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117795

Ensembl Protein ID

ENSTRUP00000015523.1

UniProt Accession

H2SSY6; H2SSY6_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

fynrk; frk

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006360.1	ENSTRUT00000015592.1	ENSTRUP00000015523.1
ENSTRUG00000006360.1	ENSTRUT00000015593.1	ENSTRUP00000015524.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-12	47.8	63	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk...elegkrGlfPenFvekle 63
            +lydy+a ++++L++++Gd+++ +  ++ +++W++++      ++k+G +P+n+v+ +e
   Q: 63   VALYDYSARTEEDLSFNAGDTLEAL--DKSNGDWWYAQAvsgVSANKEGYIPANYVAPVE 120
           68***********************..999*******9999999************9987 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MEIQKRLSAC WNSFLACFKK PTQSGGNEEQ RATVLANAGA ITEPNPRATR PPAPVATSGQ 60
FYVALYDYSA RTEEDLSFNA GDTLEALDKS NGDWWYAQAV SGVSANKEGY IPANYVAPVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGATCC AAAAAAGACT TTCGGCATGC TGGAACTCTT TCCTGGCGTG CTTTAAAAAG 60
CCGACTCAGT CCGGGGGGAA TGAAGAGCAG CGGGCCACAG TTTTGGCAAA TGCCGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000727	Aegilops tauschii	31.84	4.00e-22	100.00
IUUC-Apl-003394	Anas platyrhynchos	51.80	2.00e-153	535.00
IUUC-Aca-004553	Anolis carolinensis	57.49	1.00e-160	559.00
IUUC-Bdi-014122	Brachypodium distachyon	28.46	4.00e-23	103.00
IUUC-Cja-019885	Callithrix jacchus	54.89	4.00e-167	580.00
IUUC-Csv-026198	Ciona savignyi	50.72	7.00e-138	483.00
IUUC-Dre-028274	Danio rerio	65.28	0.00e+00	706.00
IUUC-Dno-029689	Dasypus novemcinctus	56.04	2.00e-162	565.00
IUUC-Eeu-034770	Erinaceus europaeus	46.31	4.00e-106	377.00
IUUC-Fal-036892	Ficedula albicollis	53.00	2.00e-151	528.00
IUUC-Gga-041072	Gallus gallus	54.20	7.00e-148	517.00
IUUC-Hvu-047855	Hordeum vulgare	27.38	2.00e-22	100.00
IUUC-Loc-052913	Lepisosteus oculatus	64.77	0.00e+00	687.00
IUUC-Mtr-058580	Medicago truncatula	34.36	2.00e-23	104.00
IUUC-Mga-059456	Meleagris gallopavo	53.02	2.00e-148	518.00
IUUC-Mmr-061480	Microcebus murinus	55.24	3.00e-159	555.00
IUUC-Mac-065247	Musa acuminata	31.47	1.00e-22	102.00
IUUC-Mlu-067167	Myotis lucifugus	56.65	5.00e-157	547.00
IUUC-Nle-069786	Nomascus leucogenys	54.32	2.00e-165	575.00
IUUC-Ont-072417	Oreochromis niloticus	72.39	0.00e+00	789.00
IUUC-Obr-076765	Oryza brachyantha	27.86	4.00e-23	103.00
IUUC-Ola-086419	Oryzias latipes	71.58	0.00e+00	718.00
IUUC-Pan-092732	Papio anubis	54.89	5.00e-166	577.00
IUUC-Psi-093899	Pelodiscus sinensis	57.50	6.00e-164	570.00
IUUC-Pma-094230	Petromyzon marinus	55.16	5.00e-153	534.00
IUUC-Pfo-096035	Poecilia formosa	67.33	0.00e+00	687.00
IUUC-Rno-105269	Rattus norvegicus	54.82	5.00e-163	567.00
IUUC-Sit-109712	Setaria italica	27.20	1.00e-21	98.60
IUUC-Stu-112831	Solanum tuberosum	29.55	2.00e-23	104.00
IUUC-Tgu-116491	Taeniopygia guttata	56.16	4.00e-152	531.00
IUUC-Tni-120512	Tetraodon nigroviridis	81.89	0.00e+00	901.00
IUUC-Tae-123706	Triticum aestivum	27.76	1.00e-22	102.00
IUUC-Tur-126643	Triticum urartu	32.29	4.00e-22	100.00
IUUC-Ttr-128817	Tursiops truncatus	57.53	3.00e-161	561.00
IUUC-Vpa-130389	Vicugna pacos	52.61	3.00e-148	518.00
IUUC-Vvi-131057	Vitis vinifera	33.17	2.00e-23	104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence