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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063992
Ensembl Protein ID ENSMUSP00000121182.1
UniProt Accession Q3TDN2; Q3U9W2; Q80TP7; Q80W42; FAF2_MOUSE
Genbank Protein ID BAE30554.1; BAE41569.1; AAH46817.1; BAC65676.1
Protein Name FAS-associated factor 2; UBX domain-containing protein 8
Genbank Nucleotide ID AK151617; AK170111; BC046817; AK122394
Gene Name Faf2; Kiaa0887; Ubxd8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025873.15 ENSMUST00000126071.7 ENSMUSP00000121182.1
ENSMUSG00000025873.15 ENSMUST00000135015.1 ENSMUSP00000117945.1
ENSMUSG00000025873.15 ENSMUST00000026991.15 ENSMUSP00000026991.9
ENSMUSG00000025873.15 ENSMUST00000124752.1 ENSMUSP00000121606.1
ENSMUSG00000025873.15 ENSMUST00000153894.1 ENSMUSP00000120594.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 24160817
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 1.40e-06 29.3 12 48
ULD/UDP/UFD/UBX 2.20e-16 61.3 358 439
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGF.dreealqaLraannnleaAve 36
           e+++kl q+++ +G+ + e+++ aL+++n+n eaAv 
   Q: 12   EQTEKLLQFQDlTGIeSMEQCRLALEQHNWNMEAAVQ 48
           799********************************95 PP
   

   ULD/UDP/UFD/UBX
   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehms.....tlqeagLvpsgsllv 79
           ++e++++ ++lp+++r++r+F+ s++l+ i++f+  +l+es ++F++ ++fPrr l +  +++     tlqeagL ++++l+v
   Q: 358  DPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLF-SLKESPEKFQIEANFPRRVLPCVPSEEwpnppTLQEAGLSHTEVLFV 439
           56799******************************.*************************99******************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
 Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
Protein Sequence
(Fasta)
MAAPEEQDLT QEQTEKLLQF QDLTGIESME QCRLALEQHN WNMEAAVQDR LNEQEGVPSV 60
FNPPPARPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063992|UBD,UBA;ULD,UBX|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATCACTTCC GGCGGGTGAC GGTGCGGACG GGTCAGGAGC GTAGAGGCGG CGGCAAAATG 60
GCGGCGCCTG AGGAGCAGGA TCTAACTCAG GAGCAGACCG AGAAGCTGCT GCAGTTTCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063992|UBD,UBA;ULD,UBX|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0551--Lipid droplet
KW-1185--Reference proteome
KW-0834--Unfolded protein response
Interpro

IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
SMART

SM00594--UAS
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005811--C:lipid particle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0035473--F:lipase binding
GO:0055102--F:lipase inhibitor activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0034389--P:lipid particle organization
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:76577
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000466 Aegilops tauschii 31.46 4.00e-21 96.30
IUUC-Aml-001491 Ailuropoda melanoleuca 95.26 0.00e+00 801.00
IUUC-Atr-002715 Amborella trichopoda 27.61 1.00e-27 117.00
IUUC-Apl-003340 Anas platyrhynchos 85.65 0.00e+00 738.00
IUUC-Aca-004296 Anolis carolinensis 89.46 0.00e+00 769.00
IUUC-Aly-006114 Arabidopsis lyrata 31.43 3.00e-16 79.70
IUUC-Ath-007354 Arabidopsis thaliana 30.64 2.00e-19 90.50
IUUC-Ago-007775 Ashbya gossypii 30.64 2.00e-12 67.00
IUUC-Acl-008096 Aspergillus clavatus 32.10 9.00e-26 111.00
IUUC-Afl-008447 Aspergillus flavus 31.80 8.00e-25 108.00
IUUC-Afu-008836 Aspergillus fumigatus 30.38 2.00e-24 107.00
IUUC-Ani-009247 Aspergillus nidulans 31.15 4.00e-24 106.00
IUUC-Ang-009721 Aspergillus niger 31.45 2.00e-25 110.00
IUUC-Aor-010080 Aspergillus oryzae 31.80 2.00e-24 107.00
IUUC-Ate-010379 Aspergillus terreus 33.08 4.00e-25 109.00
IUUC-Ame-010880 Astyanax mexicanus 77.93 0.00e+00 691.00
IUUC-Bgr-012032 Blumeria graminis 23.85 9.00e-20 91.70
IUUC-Bta-013187 Bos taurus 97.08 0.00e+00 825.00
IUUC-Bci-013871 Botrytis cinerea 27.96 6.00e-20 92.00
IUUC-Bdi-014964 Brachypodium distachyon 33.73 8.00e-21 95.10
IUUC-Bol-016064 Brassica oleracea 33.54 1.00e-20 94.40
IUUC-Bra-017693 Brassica rapa 31.98 2.00e-21 97.10
IUUC-Cel-018580 Caenorhabditis elegans 21.36 8.00e-05 41.60
IUUC-Cja-018867 Callithrix jacchus 91.22 0.00e+00 755.00
IUUC-Cfa-020467 Canis familiaris 97.53 0.00e+00 831.00
IUUC-Cpo-021987 Cavia porcellus 79.16 0.00e+00 706.00
IUUC-Cre-022908 Chlamydomonas reinhardtii 32.00 9.00e-17 81.60
IUUC-Csa-024081 Chlorocebus sabaeus 97.53 0.00e+00 831.00
IUUC-Cho-024488 Choloepus hoffmanni 96.85 0.00e+00 811.00
IUUC-Cin-025394 Ciona intestinalis 38.87 4.00e-60 224.00
IUUC-Csv-025919 Ciona savignyi 40.91 1.00e-65 243.00
IUUC-Cgl-026662 Colletotrichum gloeosporioides 29.00 1.00e-22 101.00
IUUC-Cne-027035 Cryptococcus neoformans 28.28 7.00e-07 48.90
IUUC-Cme-027217 Cyanidioschyzon merolae 23.68 3.00e-15 77.00
IUUC-Dre-028783 Danio rerio 82.92 0.00e+00 697.00
IUUC-Dno-029386 Dasypus novemcinctus 97.30 0.00e+00 817.00
IUUC-Dor-030740 Dipodomys ordii 73.64 7.00e-105 372.00
IUUC-Dse-031166 Dothistroma septosporum 30.56 5.00e-21 95.90
IUUC-Dme-031737 Drosophila melanogaster 42.64 8.00e-86 310.00
IUUC-Ete-033173 Echinops telfairi 96.63 0.00e+00 785.00
IUUC-Eca-033257 Equus caballus 97.09 0.00e+00 825.00
IUUC-Eeu-034927 Erinaceus europaeus 84.44 1.00e-147 515.00
IUUC-Fca-036165 Felis catus 97.53 0.00e+00 831.00
IUUC-Fal-037552 Ficedula albicollis 92.36 0.00e+00 794.00
IUUC-Fox-038042 Fusarium oxysporum 32.95 3.00e-22 100.00
IUUC-Fso-038157 Fusarium solani 29.18 2.00e-21 97.10
IUUC-Gmo-039281 Gadus morhua 83.37 0.00e+00 704.00
IUUC-Ggr-040025 Gaeumannomyces graminis 24.50 1.00e-16 81.30
IUUC-Gga-040656 Gallus gallus 92.36 0.00e+00 796.00
IUUC-Gac-041548 Gasterosteus aculeatus 82.47 0.00e+00 671.00
IUUC-Gma-043099 Glycine max 30.00 5.00e-19 89.00
IUUC-Ggo-044463 Gorilla gorilla 97.53 0.00e+00 831.00
IUUC-Hsa-045993 Homo sapiens 97.75 0.00e+00 832.00
IUUC-Hvu-047443 Hordeum vulgare 32.17 2.00e-16 79.70
IUUC-Itr-047969 Ictidomys tridecemlineatus 97.77 0.00e+00 724.00
IUUC-Kpa-049282 Komagataella pastoris 22.26 7.00e-17 82.00
IUUC-Lch-049899 Latimeria chalumnae 87.19 0.00e+00 721.00
IUUC-Lpe-050745 Leersia perrieri 35.76 1.00e-19 92.00
IUUC-Loc-052363 Lepisosteus oculatus 86.52 0.00e+00 755.00
IUUC-Lma-053279 Leptosphaeria maculans 29.36 1.00e-20 94.40
IUUC-Laf-054194 Loxodonta africana 94.14 0.00e+00 754.00
IUUC-Mcc-055811 Macaca mulatta 97.53 0.00e+00 831.00
IUUC-Meu-056391 Macropus eugenii 95.54 5.00e-99 354.00
IUUC-Mor-057016 Magnaporthe oryzae 25.95 5.00e-23 102.00
IUUC-Mpo-057383 Magnaporthe poae 30.06 2.00e-15 77.40
IUUC-Mtr-058297 Medicago truncatula 24.61 4.00e-25 108.00
IUUC-Mla-059091 Melampsora laricipopulina 29.03 1.00e-07 51.60
IUUC-Mga-059518 Meleagris gallopavo 92.47 0.00e+00 762.00
IUUC-Mvi-060414 Microbotryum violaceum 30.25 4.00e-10 60.50
IUUC-Mmr-061274 Microcebus murinus 97.53 0.00e+00 831.00
IUUC-Mdo-061873 Monodelphis domestica 92.90 0.00e+00 782.00
IUUC-Mac-064544 Musa acuminata 32.50 2.00e-16 80.10
IUUC-Mpu-066089 Mustela putorius furo 97.30 0.00e+00 830.00
IUUC-Mlu-067041 Myotis lucifugus 97.30 0.00e+00 808.00
IUUC-Nfi-068382 Neosartorya fischeri 30.77 3.00e-24 106.00
IUUC-Ncr-068916 Neurospora crassa 30.70 4.00e-23 102.00
IUUC-Nle-069007 Nomascus leucogenys 97.65 0.00e+00 794.00
IUUC-Opr-070477 Ochotona princeps 86.29 0.00e+00 699.00
IUUC-Ont-072076 Oreochromis niloticus 86.07 0.00e+00 710.00
IUUC-Oan-073466 Ornithorhynchus anatinus 78.07 2.00e-163 568.00
IUUC-Ocu-073830 Oryctolagus cuniculus 97.53 0.00e+00 817.00
IUUC-Oba-075801 Oryza barthii 35.10 4.00e-19 90.10
IUUC-Obr-076861 Oryza brachyantha 33.53 9.00e-22 98.20
IUUC-Ogl-077668 Oryza glaberrima 25.84 2.00e-21 97.10
IUUC-Ogu-078916 Oryza glumaepatula 35.10 2.00e-19 90.50
IUUC-Oin-079308 Oryza indica 35.10 2.00e-19 90.50
IUUC-Olo-080935 Oryza longistaminata 35.34 3.00e-17 84.00
IUUC-Ome-081526 Oryza meridionalis 35.10 3.00e-19 89.70
IUUC-Oni-083120 Oryza nivara 35.10 2.00e-19 90.50
IUUC-Opu-084064 Oryza punctata 35.10 2.00e-19 90.10
IUUC-Oru-084948 Oryza rufipogon 35.10 2.00e-19 90.50
IUUC-Osa-086165 Oryza sativa 35.10 2.00e-19 90.50
IUUC-Ola-086916 Oryzias latipes 85.39 0.00e+00 706.00
IUUC-Olu-087751 Ostreococcus lucimarinus 26.39 2.00e-12 66.60
IUUC-Oga-088269 Otolemur garnettii 95.92 0.00e+00 783.00
IUUC-Oar-089219 Ovis aries 96.97 0.00e+00 793.00
IUUC-Ptr-090759 Pan troglodytes 97.53 0.00e+00 831.00
IUUC-Pan-092145 Papio anubis 97.53 0.00e+00 831.00
IUUC-Psi-093285 Pelodiscus sinensis 91.80 3.00e-159 554.00
IUUC-Pno-095142 Phaeosphaeria nodorum 32.12 3.00e-26 113.00
IUUC-Ppa-095784 Physcomitrella patens 23.80 7.00e-24 105.00
IUUC-Pfo-097425 Poecilia formosa 84.27 0.00e+00 710.00
IUUC-Pab-098443 Pongo abelii 97.53 0.00e+00 831.00
IUUC-Pop-099217 Populus trichocarpa 27.63 3.00e-33 136.00
IUUC-Pca-100699 Procavia capensis 77.78 2.00e-122 432.00
IUUC-Ppe-101800 Prunus persica 26.32 3.00e-25 109.00
IUUC-Pva-103145 Pteropus vampyrus 96.48 4.00e-141 494.00
IUUC-Pgr-103629 Puccinia graminis 27.74 3.00e-09 57.00
IUUC-Ptt-103793 Puccinia triticina 26.67 4.00e-13 70.10
IUUC-Pte-104225 Pyrenophora teres 33.58 4.00e-25 109.00
IUUC-Pyt-104700 Pyrenophora triticirepentis 33.44 5.00e-25 109.00
IUUC-Rno-106093 Rattus norvegicus 98.88 0.00e+00 841.00
IUUC-Sce-106313 Saccharomyces cerevisiae 29.48 2.00e-13 70.50
IUUC-Sha-106741 Sarcophilus harrisii 83.93 0.00e+00 637.00
IUUC-Sja-107815 Schizosaccharomyces japonicus 25.99 4.00e-15 76.30
IUUC-Spo-108055 Schizosaccharomyces pombe 29.78 4.00e-11 62.80
IUUC-Smo-109471 Selaginella moellendorffii 28.67 8.00e-20 91.70
IUUC-Sit-110718 Setaria italica 36.05 2.00e-20 93.60
IUUC-Sly-111335 Solanum lycopersicum 32.57 2.00e-22 100.00
IUUC-Stu-112406 Solanum tuberosum 33.76 5.00e-20 92.40
IUUC-Sar-113215 Sorex araneus 91.69 4.00e-180 624.00
IUUC-Sbi-114324 Sorghum bicolor 37.74 4.00e-23 102.00
IUUC-Sre-114905 Sporisorium reilianum 28.98 5.00e-12 66.20
IUUC-Ssc-116024 Sus scrofa 97.20 0.00e+00 796.00
IUUC-Tgu-117287 Taeniopygia guttata 92.81 0.00e+00 798.00
IUUC-Tru-118546 Takifugu rubripes 83.60 0.00e+00 679.00
IUUC-Tsy-119080 Tarsius syrichta 95.45 3.00e-129 454.00
IUUC-Tni-120327 Tetraodon nigroviridis 66.81 2.00e-158 551.00
IUUC-Tca-121139 Theobroma cacao 29.58 6.00e-20 92.00
IUUC-Tre-121891 Trichoderma reesei 31.80 2.00e-13 70.90
IUUC-Tvi-122596 Trichoderma virens 31.30 5.00e-21 95.90
IUUC-Tae-125206 Triticum aestivum 34.50 8.00e-23 101.00
IUUC-Tur-126427 Triticum urartu 33.33 8.00e-17 80.90
IUUC-Tme-126896 Tuber melanosporum 37.35 7.00e-25 108.00
IUUC-Tbe-127474 Tupaia belangeri 83.96 0.00e+00 702.00
IUUC-Ttr-128455 Tursiops truncatus 85.62 0.00e+00 733.00
IUUC-Uma-129503 Ustilago maydis 31.30 3.00e-08 53.50
IUUC-Vda-129700 Verticillium dahliae 27.97 2.00e-24 107.00
IUUC-Vpa-130516 Vicugna pacos 87.19 0.00e+00 694.00
IUUC-Vvi-131232 Vitis vinifera 30.77 4.00e-27 115.00
IUUC-Xtr-132664 Xenopus tropicalis 84.04 0.00e+00 696.00
IUUC-Xma-133998 Xiphophorus maculatus 84.94 0.00e+00 714.00
IUUC-Yli-134397 Yarrowia lipolytica 24.67 8.00e-24 105.00
IUUC-Zma-134832 Zea mays 36.42 1.00e-20 94.00
Created Date 25-Jun-2017

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