iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036681

Ensembl Protein ID

ENSFALP00000013421.1

UniProt Accession

U3KEG7; U3KEG7_FICAL

Genbank Protein ID

ENSFALP00000013421

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01020271

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012857.1	ENSFALT00000013477.1	ENSFALP00000013421.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.20e-37	129.1	98	268
UBD/ZnF/ZnF_A20	1.20e-25	88.8	776	808

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak 76
           l++lkt+gDGnCL++A+sq+++g+ d d+ l++ l++aLre  ++++    q+e+ + +ef+e++        e+e+e++ ++ +pe  
   Q: 98   LVPLKTNGDGNCLMHAASQYMWGIEDIDLvLRKTLFSALREIDTRNFklrwQREAVKSQEFVETGlrydtrnwEEEWEYLIEMTSPEIS 186
           5789***********************************************************************************77 PP
   S: 77   g..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           g          eeihif+La+iL+rp+iv++++ ++s          +vgg++lpll+p+e+ +++pivL+Y+++H+ +Lv+
   Q: 187  GarnrlpynalEEIHIFILANILRRPVIVLADKVVRSlesgssfaplNVGGVYLPLLWPAEEcYRYPIVLGYDNMHFTPLVT 268
           66889999999*********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrr 33
           p+k++C++ +C++YGn+++ngyC++Cy++++ +
   Q: 776  PPKQRCRApACDHYGNAKCNGYCNECYQFKQIY 808
           9*****************************977 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSSRNMAGQH ILPQALYQSN MLKAMKIRER TPEDLVKPPS GIIHHFRTMH RYTIEMFRMC 60
QFCPQFRETL QKSLTDQATQ ASLERQRKLN WCREVRRLVP LKTNGDGNCL MHAASQYMWG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTCTA GAAACATGGC TGGCCAGCAC ATCCTTCCTC AAGCTTTGTA TCAGAGCAAT 60
ATGCTGAAGG CTATGAAGAT CAGAGAGAGG ACACCTGAGG ATCTAGTCAA ACCTCCCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

fab:101817397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	64.76	0.00e+00	1053.00
IUUC-Apl-003501	Anas platyrhynchos	84.28	0.00e+00	1352.00
IUUC-Aca-004245	Anolis carolinensis	68.43	0.00e+00	1120.00
IUUC-Ame-011789	Astyanax mexicanus	45.77	0.00e+00	680.00
IUUC-Bta-012664	Bos taurus	63.85	0.00e+00	1004.00
IUUC-Cja-019895	Callithrix jacchus	65.51	0.00e+00	1048.00
IUUC-Cfa-020754	Canis familiaris	65.01	0.00e+00	1053.00
IUUC-Cpo-021780	Cavia porcellus	64.39	0.00e+00	1030.00
IUUC-Csa-023568	Chlorocebus sabaeus	65.51	0.00e+00	1057.00
IUUC-Cho-024300	Choloepus hoffmanni	74.93	8.00e-157	546.00
IUUC-Csv-026177	Ciona savignyi	31.40	7.00e-03	33.90
IUUC-Dre-028577	Danio rerio	47.84	0.00e+00	673.00
IUUC-Dno-029382	Dasypus novemcinctus	63.81	0.00e+00	1019.00
IUUC-Dor-030874	Dipodomys ordii	61.68	0.00e+00	987.00
IUUC-Ete-032721	Echinops telfairi	73.73	0.00e+00	649.00
IUUC-Eca-033596	Equus caballus	64.72	0.00e+00	1041.00
IUUC-Eeu-035159	Erinaceus europaeus	61.65	0.00e+00	777.00
IUUC-Fca-035847	Felis catus	65.01	0.00e+00	1054.00
IUUC-Fox-037849	Fusarium oxysporum	29.82	1.90e-01	29.60
IUUC-Gmo-038521	Gadus morhua	58.72	1.00e-143	503.00
IUUC-Gga-040975	Gallus gallus	86.48	0.00e+00	1395.00
IUUC-Gac-042216	Gasterosteus aculeatus	59.33	7.00e-151	527.00
IUUC-Ggo-045258	Gorilla gorilla	64.89	0.00e+00	1045.00
IUUC-Hsa-046071	Homo sapiens	64.89	0.00e+00	1046.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	64.39	0.00e+00	1039.00
IUUC-Lch-050326	Latimeria chalumnae	56.34	0.00e+00	882.00
IUUC-Loc-051945	Lepisosteus oculatus	47.07	1.00e-175	609.00
IUUC-Laf-053722	Loxodonta africana	65.38	0.00e+00	1046.00
IUUC-Mcc-055503	Macaca mulatta	65.26	0.00e+00	1053.00
IUUC-Meu-056481	Macropus eugenii	61.03	0.00e+00	960.00
IUUC-Mga-059690	Meleagris gallopavo	79.48	0.00e+00	1260.00
IUUC-Mmr-061233	Microcebus murinus	64.36	0.00e+00	1026.00
IUUC-Mdo-062446	Monodelphis domestica	66.96	0.00e+00	1094.00
IUUC-Mmu-063436	Mus musculus	64.27	0.00e+00	1011.00
IUUC-Mpu-066808	Mustela putorius furo	65.76	0.00e+00	1061.00
IUUC-Mlu-067339	Myotis lucifugus	64.55	0.00e+00	1040.00
IUUC-Nle-069888	Nomascus leucogenys	64.89	0.00e+00	1045.00
IUUC-Opr-070303	Ochotona princeps	65.02	0.00e+00	1036.00
IUUC-Ont-072283	Oreochromis niloticus	57.89	2.00e-145	509.00
IUUC-Oan-072925	Ornithorhynchus anatinus	66.38	0.00e+00	1084.00
IUUC-Ocu-073889	Oryctolagus cuniculus	64.76	0.00e+00	1023.00
IUUC-Ola-087417	Oryzias latipes	58.85	1.00e-147	516.00
IUUC-Oga-088708	Otolemur garnettii	64.84	0.00e+00	1001.00
IUUC-Oar-089271	Ovis aries	63.28	0.00e+00	1006.00
IUUC-Ptr-091296	Pan troglodytes	64.89	0.00e+00	1045.00
IUUC-Pan-092474	Papio anubis	65.38	0.00e+00	1055.00
IUUC-Psi-093447	Pelodiscus sinensis	72.93	0.00e+00	1195.00
IUUC-Pfo-096511	Poecilia formosa	57.89	2.00e-146	513.00
IUUC-Pab-098700	Pongo abelii	65.26	0.00e+00	1049.00
IUUC-Pca-100246	Procavia capensis	60.41	0.00e+00	702.00
IUUC-Pva-102606	Pteropus vampyrus	62.28	4.00e-139	488.00
IUUC-Rno-105818	Rattus norvegicus	64.53	0.00e+00	1034.00
IUUC-Sha-106559	Sarcophilus harrisii	65.97	0.00e+00	1073.00
IUUC-Sar-113454	Sorex araneus	74.92	8.00e-155	540.00
IUUC-Ssc-116064	Sus scrofa	64.89	0.00e+00	1023.00
IUUC-Tgu-117212	Taeniopygia guttata	93.16	0.00e+00	1518.00
IUUC-Tru-118230	Takifugu rubripes	59.95	7.00e-150	524.00
IUUC-Tsy-119066	Tarsius syrichta	63.73	0.00e+00	1022.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.96	0.00e+00	659.00
IUUC-Tur-126383	Triticum urartu	42.86	2.00e-02	30.00
IUUC-Tbe-127601	Tupaia belangeri	74.92	6.00e-155	540.00
IUUC-Ttr-128930	Tursiops truncatus	63.52	0.00e+00	1015.00
IUUC-Vpa-130450	Vicugna pacos	74.25	8.00e-180	623.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence