iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096522

Ensembl Protein ID

ENSPFOP00000015906.2

UniProt Accession

A0A087YD03; A0A087YD03_POEFO

Genbank Protein ID

ENSPFOP00000015906

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AYCK01003266

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000015778.2	ENSPFOT00000015928.2	ENSPFOP00000015906.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-106	354.3	126	670

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 126  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 209
           7******************************.....9999999******************99999********************775 PP
   S: 89   .....qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde........................................... 129
                qqD+qEfl++l+dql+eelk+  ++  ++ e++d  e+ d                                            
   Q: 210  qqvstQQDTQEFLRCLMDQLHEELKEPLTECSMSGEGSDVDERRDGdrspsedeflscdsgsssdrgeggglgegelflqdecdgfrsp 298
           2222268*****************995555555554444444444456666667999999999************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 299  sagvgsgmvisekerlkerrvsgsplrggsqemdedadvdtaaedgapergeeeppaptanadpdneasmtqpqstpcspvrtlqelhp 387
           ***************************************************************************************** PP
   S: 130  .............................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.... 185
                                        +++kk+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+    
   Q: 388  klssspprssplrsagpaysfkkaqllltSRKKKQSHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssi 476
           *****************************99*************************************************99888**** PP
   S: 186  .............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
                                                        +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ klPe+
   Q: 477  hqnlpvktgvcpdtygsqgwisyimdsirrfvvsciptwfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLKLPEI 565
           ***************************************************************************************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG..slssGHYvayvkn.ekgkWllfdDskV 314
           L++hLkRf  ++e + + ki+++v+fple Ld++pf+++++ +q   ++Y+L++v++H+G  +  +GHY+ay++n  +g+W++fdD++V
   Q: 566  LCIHLKRF--RHEVMYSFKISSHVSFPLEgLDMQPFLAKESPSQ--VTTYDLLSVICHHGtaGNAGGHYIAYCQNvINGQWYEFDDQYV 650
           ********..9999*************************88887..9*************666679*********78999********* PP
   S: 315  tevkeeevleetgstaYvlfYkr 337
           tev+e+ v++   ++aYvlfY++
   Q: 651  TEVHETVVQN---AEAYVLFYRK 670
           **********...********98 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

GTCQSCGAGG PNLWACLQSD CSYVGCGESY ADHSTLHAQV IQAKKHNLTV NLTTFRIWCY 60
VCEREVFLDQ RPALVPVPVA SHHCKAAEQE AAVQSAGHPL KAVPIAVAEE DGSESEEDEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAACTTGCC AGTCATGTGG AGCTGGAGGT CCCAACTTAT GGGCCTGTCT GCAGGTAATT 60
TTATGAAATT GTGTCTGTGA GTCTTGCGTA ACACATGTGT GCTCCAGCAG CAGCCGGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005077	Anolis carolinensis	66.50	0.00e+00	719.00
IUUC-Ame-011777	Astyanax mexicanus	78.95	0.00e+00	1084.00
IUUC-Cho-024483	Choloepus hoffmanni	88.77	2.00e-99	357.00
IUUC-Dre-028061	Danio rerio	76.35	0.00e+00	1051.00
IUUC-Ete-032802	Echinops telfairi	63.64	9.00e-97	348.00
IUUC-Eeu-034620	Erinaceus europaeus	69.11	0.00e+00	843.00
IUUC-Gac-041315	Gasterosteus aculeatus	87.86	0.00e+00	1165.00
IUUC-Mmu-064079	Mus musculus	73.27	0.00e+00	985.00
IUUC-Mlu-067294	Myotis lucifugus	72.46	0.00e+00	963.00
IUUC-Ont-071464	Oreochromis niloticus	89.18	0.00e+00	1130.00
IUUC-Oan-073259	Ornithorhynchus anatinus	66.17	0.00e+00	817.00
IUUC-Ola-087240	Oryzias latipes	88.05	0.00e+00	1131.00
IUUC-Oar-089490	Ovis aries	70.92	0.00e+00	956.00
IUUC-Pva-102922	Pteropus vampyrus	67.01	0.00e+00	681.00
IUUC-Rno-105215	Rattus norvegicus	72.59	0.00e+00	971.00
IUUC-Sce-106176	Saccharomyces cerevisiae	31.25	2.00e-24	107.00
IUUC-Sha-106601	Sarcophilus harrisii	73.06	0.00e+00	970.00
IUUC-Tru-117770	Takifugu rubripes	88.42	0.00e+00	1171.00
IUUC-Tni-120001	Tetraodon nigroviridis	88.40	0.00e+00	1143.00
IUUC-Xtr-132157	Xenopus tropicalis	65.50	0.00e+00	906.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence