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Tag Content
UUCD2 ID IUUC-Fca-035489
UUCD1 version UUC-FeC-00618
Ensembl Protein ID ENSFCAP00000013819.3
UniProt Accession M3WLJ9; M3WLJ9_FELCA
Genbank Protein ID ENSFCAP00000013819
Protein Name Uncharacterized protein
Genbank Nucleotide ID AANG02189279
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFCAG00000014898.3 ENSFCAT00000014902.3 ENSFCAP00000013819.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.30e-127 425.0 547 876
Active Site
Position(s) Description Evidence
846 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 547  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 635
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilge...tkeeeLkpgGenipVtneNkeeYvkl 176
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+   t++++Lkp+G++i+VtneNk+eY++l
   Q: 636  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQqlqTYQVDLKPNGSEIMVTNENKREYIDL 719
           ***********************************99...6666..7********9966422267778********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           v+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +      ++L
   Q: 720  VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLM-----XRLL 803
           *****************************************************************************998.....58** PP
   S: 266  qFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           qFvTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 804  QFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 876
           ************************************************************************8 PP
   
Organism Felis catus
Protein Sequence
(Fasta)
TRDDFLGQVD IPLNHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENSEQRED MEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Fca-035489|E3,HECT|Felis catus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCGAGACG ACTTCCTGGG ACAGGTGGAC ATACCCCTGA ATCATCTCCC GGTAAGGACC 60
ATTACCTGCT TCATGGTGCA TGCCGTGAGC AGCGCTTTTC ATTGTTTCCG GTTGGGTATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Fca-035489|E3,HECT|Felis catus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 93.55 0.00e+00 1526.00
IUUC-Apl-003893 Anas platyrhynchos 90.95 0.00e+00 1523.00
IUUC-Aca-004744 Anolis carolinensis 87.57 0.00e+00 1462.00
IUUC-Ame-010810 Astyanax mexicanus 67.76 0.00e+00 1090.00
IUUC-Bta-012679 Bos taurus 95.25 0.00e+00 1562.00
IUUC-Cja-018732 Callithrix jacchus 95.14 0.00e+00 1597.00
IUUC-Cfa-021226 Canis familiaris 95.36 0.00e+00 1583.00
IUUC-Cpo-021671 Cavia porcellus 92.65 0.00e+00 1523.00
IUUC-Csa-023344 Chlorocebus sabaeus 92.90 0.00e+00 1573.00
IUUC-Cho-024832 Choloepus hoffmanni 97.46 0.00e+00 720.00
IUUC-Dre-027770 Danio rerio 76.57 0.00e+00 1229.00
IUUC-Dno-029466 Dasypus novemcinctus 94.46 0.00e+00 1585.00
IUUC-Dor-030138 Dipodomys ordii 91.23 0.00e+00 1474.00
IUUC-Ete-033145 Echinops telfairi 85.32 0.00e+00 1228.00
IUUC-Eca-033445 Equus caballus 95.59 0.00e+00 1540.00
IUUC-Eeu-035247 Erinaceus europaeus 86.88 0.00e+00 1359.00
IUUC-Fal-037604 Ficedula albicollis 88.26 0.00e+00 1496.00
IUUC-Gmo-039674 Gadus morhua 74.24 0.00e+00 1194.00
IUUC-Gga-040703 Gallus gallus 90.27 0.00e+00 1521.00
IUUC-Gac-042020 Gasterosteus aculeatus 77.21 0.00e+00 1231.00
IUUC-Ggo-045332 Gorilla gorilla 92.53 0.00e+00 1558.00
IUUC-Hsa-045968 Homo sapiens 94.68 0.00e+00 1580.00
IUUC-Lch-050443 Latimeria chalumnae 84.41 0.00e+00 1397.00
IUUC-Loc-052662 Lepisosteus oculatus 79.19 0.00e+00 1252.00
IUUC-Laf-053850 Loxodonta africana 92.87 0.00e+00 1564.00
IUUC-Mcc-055821 Macaca mulatta 94.46 0.00e+00 1579.00
IUUC-Meu-056712 Macropus eugenii 79.50 0.00e+00 674.00
IUUC-Mga-059264 Meleagris gallopavo 70.67 0.00e+00 1014.00
IUUC-Mmr-060798 Microcebus murinus 90.42 0.00e+00 1459.00
IUUC-Mdo-062173 Monodelphis domestica 91.58 0.00e+00 1577.00
IUUC-Mmu-064136 Mus musculus 93.56 0.00e+00 1548.00
IUUC-Mpu-066765 Mustela putorius furo 95.81 0.00e+00 1566.00
IUUC-Mlu-067565 Myotis lucifugus 93.33 0.00e+00 1537.00
IUUC-Nle-069070 Nomascus leucogenys 90.51 0.00e+00 1484.00
IUUC-Opr-071044 Ochotona princeps 91.58 0.00e+00 1140.00
IUUC-Ont-072044 Oreochromis niloticus 76.14 0.00e+00 1262.00
IUUC-Oan-073032 Ornithorhynchus anatinus 90.68 0.00e+00 1405.00
IUUC-Ocu-074160 Oryctolagus cuniculus 90.85 0.00e+00 1501.00
IUUC-Ola-087467 Oryzias latipes 76.23 0.00e+00 1243.00
IUUC-Oga-088460 Otolemur garnettii 90.28 0.00e+00 1509.00
IUUC-Oar-090198 Ovis aries 94.46 0.00e+00 1545.00
IUUC-Ptr-090939 Pan troglodytes 94.68 0.00e+00 1580.00
IUUC-Pan-092284 Papio anubis 94.57 0.00e+00 1577.00
IUUC-Psi-093645 Pelodiscus sinensis 91.29 0.00e+00 1523.00
IUUC-Pma-094364 Petromyzon marinus 79.05 0.00e+00 818.00
IUUC-Pab-098088 Pongo abelii 94.68 0.00e+00 1581.00
IUUC-Pca-100714 Procavia capensis 75.23 0.00e+00 1211.00
IUUC-Pva-102354 Pteropus vampyrus 92.53 0.00e+00 1520.00
IUUC-Rno-105318 Rattus norvegicus 93.56 0.00e+00 1545.00
IUUC-Sha-107482 Sarcophilus harrisii 94.00 0.00e+00 1592.00
IUUC-Ssc-115950 Sus scrofa 69.05 0.00e+00 1120.00
IUUC-Tgu-117130 Taeniopygia guttata 90.84 0.00e+00 1525.00
IUUC-Tru-118610 Takifugu rubripes 77.29 0.00e+00 1263.00
IUUC-Tsy-119492 Tarsius syrichta 92.19 0.00e+00 1552.00
IUUC-Tni-120113 Tetraodon nigroviridis 71.66 0.00e+00 1196.00
IUUC-Ttr-128235 Tursiops truncatus 93.95 0.00e+00 1029.00
IUUC-Xtr-132859 Xenopus tropicalis 86.78 0.00e+00 1454.00
Created Date 25-Jun-2017

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