iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067470

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02004499

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000014603.2	ENSMLUT00000014613.2	ENSMLUP00000013297.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	93.83	0.00e+00	1763.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
774	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

SAVDVASALP LQVAPSAVPM DLRLDHQFPL PVAEPALREQ QLQQELLALK QKQQLQRQIL 60
IAEFQRQHEQ LSRQHEAQLH EHIKHQQELL ALKHQQELLE HQRKLERHRQ EQALEKQHRE 120

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Nucleotide Sequence
(Fasta)

TCTGCAGTGG ATGTGGCCTC GGCGCTGCCT TTGCAGGTGG CTCCCTCGGC GGTGCCCATG 60
GACCTGCGCC TGGACCACCA GTTCCCGCTG CCTGTGGCGG AGCCCGCCCT CCGGGAACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	93.85	0.00e+00	1709.00
IUUC-Apl-003250	Anas platyrhynchos	87.74	0.00e+00	1612.00
IUUC-Aca-004668	Anolis carolinensis	83.12	0.00e+00	1607.00
IUUC-Ang-009522	Aspergillus niger	28.75	1.00e-33	138.00
IUUC-Bta-013215	Bos taurus	93.62	0.00e+00	1721.00
IUUC-Cja-019816	Callithrix jacchus	93.46	0.00e+00	1756.00
IUUC-Cfa-020861	Canis familiaris	94.03	0.00e+00	1717.00
IUUC-Cpo-021562	Cavia porcellus	91.23	0.00e+00	1715.00
IUUC-Csa-023612	Chlorocebus sabaeus	93.11	0.00e+00	1721.00
IUUC-Csv-026359	Ciona savignyi	56.08	5.00e-96	343.00
IUUC-Dre-028284	Danio rerio	86.84	0.00e+00	865.00
IUUC-Dno-029951	Dasypus novemcinctus	90.29	0.00e+00	1604.00
IUUC-Dor-030362	Dipodomys ordii	81.63	0.00e+00	1427.00
IUUC-Dme-031766	Drosophila melanogaster	57.28	1.00e-156	547.00
IUUC-Fca-036187	Felis catus	95.32	0.00e+00	1764.00
IUUC-Gmo-038473	Gadus morhua	77.12	0.00e+00	746.00
IUUC-Gga-040501	Gallus gallus	90.34	0.00e+00	1641.00
IUUC-Gac-042335	Gasterosteus aculeatus	70.30	0.00e+00	1271.00
IUUC-Ggo-045380	Gorilla gorilla	93.46	0.00e+00	1727.00
IUUC-Hsa-046925	Homo sapiens	93.85	0.00e+00	1726.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	92.97	0.00e+00	1701.00
IUUC-Lch-050325	Latimeria chalumnae	84.62	0.00e+00	1518.00
IUUC-Loc-052231	Lepisosteus oculatus	80.84	0.00e+00	1467.00
IUUC-Laf-054490	Loxodonta africana	86.21	0.00e+00	1652.00
IUUC-Mcc-055265	Macaca mulatta	93.23	0.00e+00	1732.00
IUUC-Meu-056676	Macropus eugenii	86.97	0.00e+00	770.00
IUUC-Mmr-061633	Microcebus murinus	84.70	0.00e+00	1518.00
IUUC-Mmu-063089	Mus musculus	92.43	0.00e+00	1652.00
IUUC-Mpu-065887	Mustela putorius furo	94.13	0.00e+00	1725.00
IUUC-Nle-069099	Nomascus leucogenys	90.78	0.00e+00	1146.00
IUUC-Ont-071613	Oreochromis niloticus	72.01	0.00e+00	1292.00
IUUC-Oan-073275	Ornithorhynchus anatinus	90.28	0.00e+00	1665.00
IUUC-Ola-087031	Oryzias latipes	67.60	0.00e+00	1205.00
IUUC-Oga-088201	Otolemur garnettii	87.79	0.00e+00	1531.00
IUUC-Oar-089997	Ovis aries	85.92	0.00e+00	1440.00
IUUC-Ptr-091116	Pan troglodytes	93.94	0.00e+00	1770.00
IUUC-Pan-092132	Papio anubis	93.42	0.00e+00	1171.00
IUUC-Psi-093734	Pelodiscus sinensis	89.74	0.00e+00	1578.00
IUUC-Pma-094347	Petromyzon marinus	70.35	0.00e+00	710.00
IUUC-Pfo-096293	Poecilia formosa	69.50	0.00e+00	1217.00
IUUC-Pab-098491	Pongo abelii	90.87	0.00e+00	1672.00
IUUC-Pca-101004	Procavia capensis	83.57	0.00e+00	940.00
IUUC-Pva-102961	Pteropus vampyrus	71.36	0.00e+00	897.00
IUUC-Rno-105005	Rattus norvegicus	92.77	0.00e+00	1634.00
IUUC-Sha-107646	Sarcophilus harrisii	67.04	0.00e+00	991.00
IUUC-Ssc-115428	Sus scrofa	93.72	0.00e+00	1677.00
IUUC-Tgu-116776	Taeniopygia guttata	89.87	0.00e+00	1628.00
IUUC-Tru-118180	Takifugu rubripes	70.22	0.00e+00	1286.00
IUUC-Tsy-119468	Tarsius syrichta	89.63	0.00e+00	780.00
IUUC-Tni-120196	Tetraodon nigroviridis	71.12	0.00e+00	1274.00
IUUC-Ttr-128360	Tursiops truncatus	84.19	0.00e+00	997.00
IUUC-Xtr-132956	Xenopus tropicalis	81.60	0.00e+00	1442.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence