iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088201

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AAQR03144283

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004929.2	ENSOGAT00000004935.2	ENSOGAP00000004404.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	88.99	0.00e+00	1543.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
757	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Otolemur garnettii

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

EPALREQQLQ QELLALKQKQ QIQRQLLIAE FQRQHEQLSR QHEAQLHEHI KQQQEMLAMK 60
HQQELLEHQR KLERHRQEQE LEKQHREQKL QQLKNKEKGK ESAVASTEVK MKLQEFVLNK 120

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Nucleotide Sequence
(Fasta)

GAGCCCGCCC TCCGGGAGCA GCAGTTGCAG CAGGAGCTCC TGGCGCTCAA GCAGAAGCAG 60
CAGATCCAGA GACAGCTCCT CATCGCTGAG TTCCAGCGGC AGCACGAGCA GCTGTCCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	86.59	0.00e+00	1559.00
IUUC-Apl-003250	Anas platyrhynchos	81.84	0.00e+00	1445.00
IUUC-Aca-004668	Anolis carolinensis	78.09	0.00e+00	1455.00
IUUC-Bta-013215	Bos taurus	86.51	0.00e+00	1566.00
IUUC-Cja-019816	Callithrix jacchus	88.57	0.00e+00	1602.00
IUUC-Cfa-020861	Canis familiaris	87.44	0.00e+00	1571.00
IUUC-Cpo-021562	Cavia porcellus	87.54	0.00e+00	1581.00
IUUC-Csa-023612	Chlorocebus sabaeus	87.62	0.00e+00	1574.00
IUUC-Csv-026359	Ciona savignyi	55.74	2.00e-96	345.00
IUUC-Dre-028284	Danio rerio	85.35	0.00e+00	851.00
IUUC-Dno-029951	Dasypus novemcinctus	83.03	0.00e+00	1444.00
IUUC-Dor-030362	Dipodomys ordii	77.03	0.00e+00	1293.00
IUUC-Dme-031766	Drosophila melanogaster	57.98	3.00e-159	556.00
IUUC-Fca-036187	Felis catus	88.22	0.00e+00	1635.00
IUUC-Gmo-038473	Gadus morhua	75.64	0.00e+00	731.00
IUUC-Gga-040501	Gallus gallus	85.11	0.00e+00	1480.00
IUUC-Gac-042335	Gasterosteus aculeatus	67.03	0.00e+00	1159.00
IUUC-Ggo-045380	Gorilla gorilla	88.57	0.00e+00	1577.00
IUUC-Hsa-046925	Homo sapiens	88.97	0.00e+00	1582.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	88.44	0.00e+00	1567.00
IUUC-Lch-050325	Latimeria chalumnae	79.48	0.00e+00	1365.00
IUUC-Loc-052231	Lepisosteus oculatus	76.20	0.00e+00	1318.00
IUUC-Laf-054490	Loxodonta africana	80.74	0.00e+00	1500.00
IUUC-Mcc-055265	Macaca mulatta	87.57	0.00e+00	1585.00
IUUC-Meu-056676	Macropus eugenii	85.62	0.00e+00	752.00
IUUC-Mmr-061633	Microcebus murinus	92.27	0.00e+00	1207.00
IUUC-Mmu-063089	Mus musculus	87.27	0.00e+00	1515.00
IUUC-Mpu-065887	Mustela putorius furo	87.64	0.00e+00	1580.00
IUUC-Mlu-067470	Myotis lucifugus	87.73	0.00e+00	1595.00
IUUC-Nle-069099	Nomascus leucogenys	83.47	0.00e+00	990.00
IUUC-Ont-071613	Oreochromis niloticus	67.38	0.00e+00	1177.00
IUUC-Oan-073275	Ornithorhynchus anatinus	84.14	0.00e+00	1493.00
IUUC-Ola-087031	Oryzias latipes	63.72	0.00e+00	1096.00
IUUC-Oar-089997	Ovis aries	78.78	0.00e+00	1323.00
IUUC-Ptr-091116	Pan troglodytes	89.17	0.00e+00	1620.00
IUUC-Pan-092132	Papio anubis	94.18	0.00e+00	1174.00
IUUC-Psi-093734	Pelodiscus sinensis	84.18	0.00e+00	1424.00
IUUC-Pma-094347	Petromyzon marinus	70.35	0.00e+00	702.00
IUUC-Pfo-096293	Poecilia formosa	65.61	0.00e+00	1125.00
IUUC-Pab-098491	Pongo abelii	86.16	0.00e+00	1526.00
IUUC-Pca-101004	Procavia capensis	75.68	0.00e+00	834.00
IUUC-Pva-102961	Pteropus vampyrus	64.58	0.00e+00	781.00
IUUC-Rno-105005	Rattus norvegicus	87.07	0.00e+00	1518.00
IUUC-Sha-107646	Sarcophilus harrisii	60.69	0.00e+00	876.00
IUUC-Ssc-115428	Sus scrofa	86.71	0.00e+00	1535.00
IUUC-Tgu-116776	Taeniopygia guttata	84.77	0.00e+00	1471.00
IUUC-Tru-118180	Takifugu rubripes	66.86	0.00e+00	1174.00
IUUC-Tsy-119468	Tarsius syrichta	89.63	0.00e+00	777.00
IUUC-Tni-120196	Tetraodon nigroviridis	67.78	0.00e+00	1172.00
IUUC-Ttr-128360	Tursiops truncatus	83.10	0.00e+00	987.00
IUUC-Xtr-132956	Xenopus tropicalis	74.32	0.00e+00	1297.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence