iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069977

Ensembl Protein ID

ENSNLEP00000015256.2

UniProt Accession

G1RPU2; G1RPU2_NOMLE

Genbank Protein ID

ENSNLEP00000015256

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADFV01097320

Gene Name

ABL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000012556.2	ENSNLET00000016028.2	ENSNLEP00000015256.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-14	53.0	82	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 82   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 139
           68899************************.***********..79999**********997 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LTEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATGTCACT ACGGCCCCAT TAGTCTCAGC TCAGCCAAAC TTTAATGCAA AGGAAAAGTC 60
TGGATTGGTT CCACAGGCCT TTTAAAAAGC GGACTTAAAA GTTGCTGGCA ATGCATTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:1990051--P:activation of protein kinase C activity
GO:0070301--P:cellular response to hydrogen peroxide
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0045184--P:establishment of protein localization
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:1904528--P:positive regulation of microtubule binding
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	88.65	0.00e+00	1392.00
IUUC-Apl-003452	Anas platyrhynchos	82.31	0.00e+00	1200.00
IUUC-Aca-005312	Anolis carolinensis	77.38	0.00e+00	1124.00
IUUC-Ame-011903	Astyanax mexicanus	76.97	0.00e+00	963.00
IUUC-Bta-012351	Bos taurus	87.95	0.00e+00	1337.00
IUUC-Cja-019491	Callithrix jacchus	92.03	0.00e+00	1444.00
IUUC-Cfa-021256	Canis familiaris	88.77	0.00e+00	1421.00
IUUC-Cpo-022046	Cavia porcellus	87.41	0.00e+00	1410.00
IUUC-Csa-023046	Chlorocebus sabaeus	81.98	0.00e+00	1632.00
IUUC-Dre-028190	Danio rerio	62.59	0.00e+00	1153.00
IUUC-Dno-029853	Dasypus novemcinctus	79.48	0.00e+00	1656.00
IUUC-Eca-033720	Equus caballus	87.87	0.00e+00	1316.00
IUUC-Eeu-035173	Erinaceus europaeus	83.86	0.00e+00	1290.00
IUUC-Fca-035967	Felis catus	89.37	0.00e+00	1397.00
IUUC-Fal-036723	Ficedula albicollis	82.95	0.00e+00	1208.00
IUUC-Gmo-039550	Gadus morhua	71.36	0.00e+00	1022.00
IUUC-Gga-040481	Gallus gallus	82.31	0.00e+00	1190.00
IUUC-Gac-041643	Gasterosteus aculeatus	71.90	0.00e+00	1022.00
IUUC-Ggo-045299	Gorilla gorilla	93.00	0.00e+00	1483.00
IUUC-Hsa-047033	Homo sapiens	98.65	3.00e-41	158.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	88.12	0.00e+00	1298.00
IUUC-Lch-050530	Latimeria chalumnae	78.32	0.00e+00	1222.00
IUUC-Loc-052430	Lepisosteus oculatus	79.41	0.00e+00	936.00
IUUC-Laf-053609	Loxodonta africana	88.16	0.00e+00	1372.00
IUUC-Mcc-055654	Macaca mulatta	82.60	0.00e+00	1765.00
IUUC-Mga-059270	Meleagris gallopavo	82.41	0.00e+00	1225.00
IUUC-Mmr-060593	Microcebus murinus	89.09	0.00e+00	1363.00
IUUC-Mdo-062227	Monodelphis domestica	84.83	0.00e+00	1243.00
IUUC-Mmu-064002	Mus musculus	84.97	0.00e+00	1380.00
IUUC-Mpu-066197	Mustela putorius furo	87.92	0.00e+00	1426.00
IUUC-Mlu-067255	Myotis lucifugus	88.25	0.00e+00	1294.00
IUUC-Ont-072307	Oreochromis niloticus	60.85	0.00e+00	1135.00
IUUC-Oan-073100	Ornithorhynchus anatinus	83.85	0.00e+00	1269.00
IUUC-Ocu-074892	Oryctolagus cuniculus	83.31	0.00e+00	1189.00
IUUC-Ola-087389	Oryzias latipes	61.73	0.00e+00	952.00
IUUC-Oga-088145	Otolemur garnettii	89.78	0.00e+00	1299.00
IUUC-Oar-090432	Ovis aries	82.93	0.00e+00	1566.00
IUUC-Ptr-090800	Pan troglodytes	93.00	0.00e+00	1482.00
IUUC-Psi-093078	Pelodiscus sinensis	82.18	0.00e+00	1253.00
IUUC-Pfo-096979	Poecilia formosa	69.63	0.00e+00	960.00
IUUC-Pca-100874	Procavia capensis	99.47	0.00e+00	770.00
IUUC-Pva-102415	Pteropus vampyrus	88.12	0.00e+00	1412.00
IUUC-Rno-105682	Rattus norvegicus	85.21	0.00e+00	1361.00
IUUC-Sha-106711	Sarcophilus harrisii	74.48	0.00e+00	1481.00
IUUC-Ssc-115472	Sus scrofa	88.65	0.00e+00	1414.00
IUUC-Tgu-117037	Taeniopygia guttata	83.76	0.00e+00	1320.00
IUUC-Tru-118324	Takifugu rubripes	62.88	0.00e+00	979.00
IUUC-Tsy-119216	Tarsius syrichta	89.75	0.00e+00	1069.00
IUUC-Tni-119950	Tetraodon nigroviridis	54.98	0.00e+00	997.00
IUUC-Ttr-128209	Tursiops truncatus	89.73	0.00e+00	1456.00
IUUC-Xtr-132477	Xenopus tropicalis	69.18	0.00e+00	941.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence