iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000005132.1	ENSSHAT00000005937.1	ENSSHAP00000005883.1
ENSSHAG00000005132.1	ENSSHAT00000005938.1	ENSSHAP00000005884.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-121	405.8	936	1266

Active Site

Position(s)	Description	Evidence
1236	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld
   Q: 936  DYLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRIAGMAVYHGKLLD 1022
           56899********************************************************************************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
            ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d    +ldl+f+v+ee++g+t+++eLk gG++i Vtn+Nk+eY++l
   Q: 1023 GFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPA--ELDLRFTVDEELFGQTHQHELKNGGSEIVVTNKNKKEYIHL 1104
           ************************************99...555..5899999********************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           v+++r+ ++i++q+ af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw++   f s  r +
   Q: 1105 VIQWRFVNRIQKQMSAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKASIIFISIRRIT 1191
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            + F+ +ssrlPl+  +e      p++f++++++++++lP+++TCfn+L+LP+Y+s e l +kL++Aie+t+gF+
   Q: 1192 AIYFLVNSSRLPLAPYQEQIgsngPQFFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLQIAIENTQGFD 1266
           ************855555447888**************************************************8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

EQMAQLLFAS RRSNICSLSE TSGDELDNIH MSFKRSTKIS TSNIIHMKLT ASLAPQTQEN 60
TKSQEGTTEP SSQNISKKGN FLQISLQPTR YSRYLKSDNV VTTGEDKVST HVLTGGIYNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCCCGCT CCTCCCCGCT TCTGCCGCCG CGATTCCCCG CCGGCGCGTC CGGGGATCCG 60
AGGAGCCCAG AAGTTACCCG GCTCGGCTGG CCCATGGCAG CTTCTTCGGT GGGAGTGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	67.25	0.00e+00	1714.00
IUUC-Apl-003886	Anas platyrhynchos	71.40	0.00e+00	1175.00
IUUC-Bta-012453	Bos taurus	66.32	0.00e+00	1664.00
IUUC-Cja-019034	Callithrix jacchus	77.73	0.00e+00	1206.00
IUUC-Cfa-020258	Canis familiaris	67.19	0.00e+00	1673.00
IUUC-Cpo-021648	Cavia porcellus	76.15	0.00e+00	1268.00
IUUC-Csa-023334	Chlorocebus sabaeus	79.75	0.00e+00	1287.00
IUUC-Dre-027924	Danio rerio	65.70	0.00e+00	871.00
IUUC-Dno-029159	Dasypus novemcinctus	79.02	0.00e+00	1167.00
IUUC-Ete-032409	Echinops telfairi	76.13	0.00e+00	1067.00
IUUC-Eca-033441	Equus caballus	79.38	0.00e+00	1236.00
IUUC-Eeu-034546	Erinaceus europaeus	66.49	0.00e+00	1003.00
IUUC-Fca-036384	Felis catus	66.77	0.00e+00	1703.00
IUUC-Fal-037547	Ficedula albicollis	76.52	0.00e+00	1227.00
IUUC-Gga-040524	Gallus gallus	77.64	0.00e+00	1230.00
IUUC-Gac-042607	Gasterosteus aculeatus	64.03	0.00e+00	1040.00
IUUC-Hsa-046479	Homo sapiens	68.00	0.00e+00	1724.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	70.03	0.00e+00	1027.00
IUUC-Lch-050445	Latimeria chalumnae	53.78	0.00e+00	1294.00
IUUC-Loc-052645	Lepisosteus oculatus	68.76	0.00e+00	1122.00
IUUC-Mcc-055585	Macaca mulatta	68.08	0.00e+00	1712.00
IUUC-Meu-056897	Macropus eugenii	63.46	3.00e-177	615.00
IUUC-Mga-059362	Meleagris gallopavo	71.36	0.00e+00	1202.00
IUUC-Mmr-061061	Microcebus murinus	67.32	0.00e+00	1726.00
IUUC-Mmu-063318	Mus musculus	68.66	0.00e+00	1106.00
IUUC-Mpu-066567	Mustela putorius furo	79.31	0.00e+00	1298.00
IUUC-Mlu-068148	Myotis lucifugus	66.87	0.00e+00	1690.00
IUUC-Nle-069225	Nomascus leucogenys	66.49	0.00e+00	1721.00
IUUC-Oan-073019	Ornithorhynchus anatinus	80.97	0.00e+00	1290.00
IUUC-Ocu-074409	Oryctolagus cuniculus	65.61	0.00e+00	1653.00
IUUC-Oga-088241	Otolemur garnettii	63.15	0.00e+00	1508.00
IUUC-Oar-089797	Ovis aries	78.76	0.00e+00	1287.00
IUUC-Ptr-091629	Pan troglodytes	78.53	0.00e+00	1176.00
IUUC-Psi-093618	Pelodiscus sinensis	63.18	0.00e+00	1456.00
IUUC-Pfo-097145	Poecilia formosa	64.92	0.00e+00	1016.00
IUUC-Pab-098394	Pongo abelii	79.25	0.00e+00	1283.00
IUUC-Pca-100568	Procavia capensis	66.71	0.00e+00	984.00
IUUC-Rno-106095	Rattus norvegicus	68.16	0.00e+00	1103.00
IUUC-Tgu-117474	Taeniopygia guttata	76.77	0.00e+00	1234.00
IUUC-Tru-117675	Takifugu rubripes	62.29	0.00e+00	1008.00
IUUC-Tni-119993	Tetraodon nigroviridis	60.84	0.00e+00	1002.00
IUUC-Tbe-127408	Tupaia belangeri	72.35	0.00e+00	972.00
IUUC-Ttr-128437	Tursiops truncatus	71.29	0.00e+00	985.00
IUUC-Vpa-130503	Vicugna pacos	75.88	0.00e+00	1132.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence