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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064389
UUCD1 version UUC-MuM-00027
Ensembl Protein ID ENSMUSP00000038775.7
UniProt Accession Q6A009; E9QN94; Q6PIW6; Q8BZ44; LTN1_MOUSE
Genbank Protein ID BAD32287.1; BAC29552.1; AAH27795.1
Protein Name E3 ubiquitin-protein ligase listerin; RING finger protein 160; RING-type E3 ubiquitin transferase listerin; Zinc finger protein 294
Genbank Nucleotide ID AK173009; AC140319; BC027795
Gene Name Ltn1; Kiaa0714; Lister; Rnf160; Zfp294; Znf294
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000052299.8 ENSMUST00000039449.7 ENSMUSP00000038775.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19196968
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0039 18.8 1716 1763
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +        k+  +   C+  fh  Cl+kw      ss++ +CPlCr
   Q: 1716 CMICFSVIhgfnyslpKK-AC-RTCKKKFHSACLYKW----FTSSNKSTCPLCR 1763
           99**99776655555444.44.45*************....99**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase (PubMed:19196968). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Ubiquitination leads to Vcp/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
 E3 ubiquitin-protein ligase (PubMed:19196968). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Ubiquitination leads to Vcp/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
Protein Sequence
(Fasta)
MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SHSDLGYVPA VQGAEDIDSL 60
VDSDFRMVLR KLSKKDVTTK LKAMQEFGIM CTERDTEAVK GVLPYWPRIF CKISLDHDRR 120
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Protein Fasta Sequence


>IUUC-Mmu-064389|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AAGTAGGAAG CCGAAAGGCT GGGAGGGCGA GGGGGAAGTG GCTACAGTGA ATCCCCTTCC 60
GGCGCGAGGG ACCGGAAGTT GTGGCCCGCC CGTGTCAACT TCGGCTCTGC AGACTGAGAG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064389|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00744--RINGv
Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination
KEGG mmu:78913
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000717 Aegilops tauschii 42.16 5.00e-48 187.00
IUUC-Aml-002311 Ailuropoda melanoleuca 83.94 0.00e+00 2828.00
IUUC-Atr-002905 Amborella trichopoda 40.95 6.00e-49 190.00
IUUC-Apl-003323 Anas platyrhynchos 64.75 0.00e+00 2088.00
IUUC-Aca-004616 Anolis carolinensis 62.98 0.00e+00 2083.00
IUUC-Aly-006145 Arabidopsis lyrata 40.80 1.00e-44 176.00
IUUC-Ath-006844 Arabidopsis thaliana 42.29 3.00e-47 185.00
IUUC-Ago-007750 Ashbya gossypii 32.33 2.00e-44 174.00
IUUC-Acl-008369 Aspergillus clavatus 29.24 7.00e-40 160.00
IUUC-Afl-008540 Aspergillus flavus 32.44 2.00e-39 159.00
IUUC-Afu-009089 Aspergillus fumigatus 29.58 1.00e-41 166.00
IUUC-Ani-009292 Aspergillus nidulans 30.06 3.00e-38 154.00
IUUC-Ang-009715 Aspergillus niger 29.79 7.00e-37 150.00
IUUC-Aor-009887 Aspergillus oryzae 32.44 2.00e-39 159.00
IUUC-Ate-010308 Aspergillus terreus 28.06 1.00e-30 129.00
IUUC-Ame-011345 Astyanax mexicanus 52.74 0.00e+00 1679.00
IUUC-Bgr-012196 Blumeria graminis 25.23 6.00e-18 87.40
IUUC-Bta-012535 Bos taurus 83.14 0.00e+00 2822.00
IUUC-Bci-013630 Botrytis cinerea 30.67 1.00e-40 162.00
IUUC-Bdi-014142 Brachypodium distachyon 44.12 2.00e-50 195.00
IUUC-Bol-015333 Brassica oleracea 40.98 2.00e-46 182.00
IUUC-Cel-018254 Caenorhabditis elegans 41.90 4.00e-45 177.00
IUUC-Cja-019469 Callithrix jacchus 84.78 0.00e+00 2911.00
IUUC-Cfa-020640 Canis familiaris 83.47 0.00e+00 2840.00
IUUC-Cpo-021322 Cavia porcellus 81.41 0.00e+00 2436.00
IUUC-Cre-022677 Chlamydomonas reinhardtii 37.56 6.00e-35 143.00
IUUC-Csa-024234 Chlorocebus sabaeus 85.24 0.00e+00 2864.00
IUUC-Cho-024709 Choloepus hoffmanni 73.37 0.00e+00 1131.00
IUUC-Csv-026100 Ciona savignyi 25.17 1.00e-68 255.00
IUUC-Cgl-026482 Colletotrichum gloeosporioides 25.09 3.00e-13 71.60
IUUC-Cne-026789 Cryptococcus neoformans 32.14 1.00e-37 152.00
IUUC-Cme-027135 Cyanidioschyzon merolae 33.78 4.00e-12 68.60
IUUC-Dre-027405 Danio rerio 51.87 0.00e+00 1618.00
IUUC-Dno-029874 Dasypus novemcinctus 79.51 0.00e+00 2204.00
IUUC-Dor-030589 Dipodomys ordii 88.93 0.00e+00 1313.00
IUUC-Dse-031427 Dothistroma septosporum 30.20 4.00e-40 160.00
IUUC-Dme-031827 Drosophila melanogaster 32.46 9.00e-73 269.00
IUUC-Ete-032459 Echinops telfairi 67.34 0.00e+00 810.00
IUUC-Eca-033218 Equus caballus 85.14 0.00e+00 2881.00
IUUC-Eeu-035299 Erinaceus europaeus 69.48 0.00e+00 1786.00
IUUC-Fca-036081 Felis catus 83.48 0.00e+00 2829.00
IUUC-Fal-037561 Ficedula albicollis 64.76 0.00e+00 2095.00
IUUC-Fox-037930 Fusarium oxysporum 28.33 3.00e-39 158.00
IUUC-Fso-038413 Fusarium solani 25.79 2.00e-37 152.00
IUUC-Gmo-039359 Gadus morhua 48.39 0.00e+00 1513.00
IUUC-Ggr-039744 Gaeumannomyces graminis 29.43 4.00e-37 151.00
IUUC-Gga-041175 Gallus gallus 64.78 0.00e+00 2149.00
IUUC-Gac-041943 Gasterosteus aculeatus 47.79 0.00e+00 1505.00
IUUC-Gma-043888 Glycine max 40.10 4.00e-48 187.00
IUUC-Ggo-044912 Gorilla gorilla 81.72 0.00e+00 1705.00
IUUC-Hsa-047016 Homo sapiens 85.35 0.00e+00 2924.00
IUUC-Hvu-047059 Hordeum vulgare 43.14 2.00e-49 192.00
IUUC-Itr-048789 Ictidomys tridecemlineatus 90.16 0.00e+00 1403.00
IUUC-Kpa-049133 Komagataella pastoris 37.38 9.00e-39 156.00
IUUC-Lch-049879 Latimeria chalumnae 51.85 0.00e+00 1511.00
IUUC-Lpe-051455 Leersia perrieri 42.58 5.00e-50 194.00
IUUC-Loc-052799 Lepisosteus oculatus 54.70 0.00e+00 1859.00
IUUC-Lma-052972 Leptosphaeria maculans 29.09 2.00e-38 155.00
IUUC-Laf-053479 Loxodonta africana 79.76 0.00e+00 2715.00
IUUC-Mcc-055120 Macaca mulatta 85.24 0.00e+00 2920.00
IUUC-Meu-055932 Macropus eugenii 71.37 0.00e+00 741.00
IUUC-Mor-057209 Magnaporthe oryzae 33.33 2.00e-41 165.00
IUUC-Mpo-057581 Magnaporthe poae 28.67 1.00e-33 139.00
IUUC-Mtr-058499 Medicago truncatula 41.55 3.00e-49 191.00
IUUC-Mla-059169 Melampsora laricipopulina 46.97 5.00e-37 146.00
IUUC-Mga-059800 Meleagris gallopavo 64.70 0.00e+00 2123.00
IUUC-Mvi-060350 Microbotryum violaceum 36.16 6.00e-54 207.00
IUUC-Mmr-061548 Microcebus murinus 84.52 0.00e+00 2944.00
IUUC-Mdo-062405 Monodelphis domestica 68.05 0.00e+00 2253.00
IUUC-Mac-064596 Musa acuminata 32.06 9.00e-51 196.00
IUUC-Mpu-065687 Mustela putorius furo 83.77 0.00e+00 2870.00
IUUC-Mlu-067591 Myotis lucifugus 79.27 0.00e+00 2636.00
IUUC-Nfi-068298 Neosartorya fischeri 28.95 4.00e-41 164.00
IUUC-Ncr-068876 Neurospora crassa 31.10 1.00e-41 166.00
IUUC-Nle-069799 Nomascus leucogenys 85.41 0.00e+00 2907.00
IUUC-Opr-071155 Ochotona princeps 67.72 0.00e+00 1117.00
IUUC-Ont-071290 Oreochromis niloticus 49.11 0.00e+00 1593.00
IUUC-Ocu-074947 Oryctolagus cuniculus 85.31 0.00e+00 2921.00
IUUC-Oba-075986 Oryza barthii 42.58 3.00e-50 194.00
IUUC-Obr-076304 Oryza brachyantha 43.63 1.00e-49 192.00
IUUC-Ogl-077600 Oryza glaberrima 42.58 4.00e-50 194.00
IUUC-Ogu-078079 Oryza glumaepatula 42.58 4.00e-50 194.00
IUUC-Oin-079935 Oryza indica 42.58 4.00e-50 194.00
IUUC-Olo-080897 Oryza longistaminata 42.58 4.00e-50 194.00
IUUC-Ome-081777 Oryza meridionalis 42.58 4.00e-50 194.00
IUUC-Oni-082298 Oryza nivara 42.58 3.00e-50 194.00
IUUC-Opu-083156 Oryza punctata 42.58 5.00e-50 194.00
IUUC-Oru-085243 Oryza rufipogon 42.58 3.00e-50 194.00
IUUC-Osa-086219 Oryza sativa 42.58 4.00e-50 194.00
IUUC-Ola-087202 Oryzias latipes 47.76 0.00e+00 1539.00
IUUC-Olu-087800 Ostreococcus lucimarinus 35.05 4.00e-43 171.00
IUUC-Oga-088962 Otolemur garnettii 84.70 0.00e+00 2976.00
IUUC-Oar-089858 Ovis aries 83.14 0.00e+00 2837.00
IUUC-Ptr-090958 Pan troglodytes 85.63 0.00e+00 2937.00
IUUC-Pan-092712 Papio anubis 85.24 0.00e+00 2944.00
IUUC-Psi-093557 Pelodiscus sinensis 66.29 0.00e+00 2295.00
IUUC-Pma-094131 Petromyzon marinus 56.82 8.00e-129 453.00
IUUC-Pno-094947 Phaeosphaeria nodorum 28.84 6.00e-38 153.00
IUUC-Ppa-095258 Physcomitrella patens 43.63 1.00e-52 202.00
IUUC-Pfo-097035 Poecilia formosa 48.95 0.00e+00 1519.00
IUUC-Pab-097897 Pongo abelii 84.90 0.00e+00 2778.00
IUUC-Pop-099487 Populus trichocarpa 40.48 2.00e-47 185.00
IUUC-Pca-100688 Procavia capensis 62.99 0.00e+00 1268.00
IUUC-Ppe-101821 Prunus persica 40.00 2.00e-48 189.00
IUUC-Pva-102632 Pteropus vampyrus 82.19 0.00e+00 1878.00
IUUC-Pgr-103311 Puccinia graminis 36.27 4.00e-52 201.00
IUUC-Ptt-103825 Puccinia triticina 34.42 1.00e-43 172.00
IUUC-Pte-104036 Pyrenophora teres 26.77 6.00e-38 154.00
IUUC-Pyt-104460 Pyrenophora triticirepentis 27.70 2.00e-38 155.00
IUUC-Rno-104852 Rattus norvegicus 92.82 0.00e+00 3207.00
IUUC-Sce-106305 Saccharomyces cerevisiae 31.53 5.00e-46 180.00
IUUC-Sja-107896 Schizosaccharomyces japonicus 38.76 3.00e-43 171.00
IUUC-Spo-108267 Schizosaccharomyces pombe 35.93 7.00e-46 180.00
IUUC-Smo-109180 Selaginella moellendorffii 35.25 2.00e-49 192.00
IUUC-Sit-110615 Setaria italica 41.90 4.00e-49 191.00
IUUC-Sly-111861 Solanum lycopersicum 41.90 7.00e-50 193.00
IUUC-Stu-112373 Solanum tuberosum 41.90 4.00e-50 193.00
IUUC-Sar-113666 Sorex araneus 76.96 0.00e+00 2110.00
IUUC-Sbi-114597 Sorghum bicolor 44.12 1.00e-50 196.00
IUUC-Sre-114965 Sporisorium reilianum 31.88 2.00e-46 182.00
IUUC-Ssc-115866 Sus scrofa 84.62 0.00e+00 2918.00
IUUC-Tgu-117521 Taeniopygia guttata 64.64 0.00e+00 2146.00
IUUC-Tru-117803 Takifugu rubripes 46.41 0.00e+00 1467.00
IUUC-Tsy-119135 Tarsius syrichta 79.65 0.00e+00 2146.00
IUUC-Tni-119807 Tetraodon nigroviridis 46.57 0.00e+00 1446.00
IUUC-Tca-121036 Theobroma cacao 40.95 6.00e-49 190.00
IUUC-Tre-121942 Trichoderma reesei 29.00 2.00e-38 155.00
IUUC-Tvi-122453 Trichoderma virens 28.33 1.00e-37 152.00
IUUC-Tae-123061 Triticum aestivum 42.16 6.00e-48 187.00
IUUC-Tur-126021 Triticum urartu 42.16 4.00e-48 187.00
IUUC-Tme-126889 Tuber melanosporum 33.68 1.00e-45 179.00
IUUC-Tbe-127297 Tupaia belangeri 73.56 0.00e+00 1143.00
IUUC-Ttr-128745 Tursiops truncatus 84.28 0.00e+00 2888.00
IUUC-Uma-129552 Ustilago maydis 32.65 4.00e-47 184.00
IUUC-Vda-129838 Verticillium dahliae 29.67 3.00e-40 161.00
IUUC-Vpa-130567 Vicugna pacos 84.61 0.00e+00 1513.00
IUUC-Vvi-131418 Vitis vinifera 41.43 3.00e-51 197.00
IUUC-Xtr-132926 Xenopus tropicalis 57.88 0.00e+00 1978.00
IUUC-Xma-134278 Xiphophorus maculatus 48.69 0.00e+00 1511.00
IUUC-Yli-134476 Yarrowia lipolytica 36.52 2.00e-49 191.00
IUUC-Zma-135611 Zea mays 42.79 5.00e-50 194.00
Created Date 25-Jun-2017

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