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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046587
Ensembl Protein ID ENSP00000369318.3
UniProt Accession O94955; A0PJA4; A8K1W9; Q8IW06; RHBT3_HUMAN
Genbank Protein ID BAA74901.2; BAF82723.1; AAH20231.1; AAH41337.1
Protein Name Rho-related BTB domain-containing protein 3
Genbank Nucleotide ID AB020685; AK290034; BC020231; BC041337
Gene Name RHOBTB3; KIAA0878
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164292.12 ENST00000506959.5 ENSP00000423688.1
ENSG00000164292.12 ENST00000506817.1 ENSP00000426479.1
ENSG00000164292.12 ENST00000379982.7 ENSP00000369318.3
ENSG00000164292.12 ENST00000510623.1 ENSP00000423652.1
ENSG00000164292.12 ENST00000502541.1 ENSP00000421875.1
ENSG00000164292.12 ENST00000504179.5 ENSP00000422360.1
ENSG00000164292.12 ENST00000510313.1 ENSP00000424844.1
ENSG00000164292.12 ENST00000503737.1 ENSP00000426390.1
ENSG00000164292.12 ENST00000513091.1 ENSP00000425342.1
ENSG00000164292.12 ENST00000514198.1 ENSP00000424700.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other BTB_Other 18835386
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.50e-28 99.9 420 482
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgk 64
           aDv+++++g+ ++ah+++L a+++v+ a+f+++  e k +  + + +v+ e f  +l++lYt++
   Q: 420  ADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAK-SVLIPVYGVSKETFLSFLEYLYTDS 482
           7***********************************99.55566667***************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
 Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
Protein Sequence
(Fasta)
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA 60
SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046587|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCTTCTGCC ATGATTGGAA ATTTCCTGAG GCCTCCCCAG AAGCAGAATC CTGTACAGCC 60
TGCAGAATTG TGAGCCATTA AATCTCTTTT CTTTATAAAT TACCTAGTCG CAGGTATGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046587|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR000210--BTB/POZ_dom
IPR027417--P-loop_NTPase
IPR031260--RhoBTB3
IPR011333--SKP1/BTB/POZ
IPR001806--Small_GTPase
PROSITE

PS50097--BTB
Pfam

PF00651--BTB
PF00071--Ras
SMART

SM00225--BTB
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0032588--C:trans-Golgi network membrane
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0017137--F:Rab GTPase binding
GO:0008584--P:male gonad development
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0007264--P:small GTPase mediated signal transduction
KEGG hsa:22836
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001703 Ailuropoda melanoleuca 98.03 0.00e+00 1252.00
IUUC-Apl-003597 Anas platyrhynchos 72.25 0.00e+00 766.00
IUUC-Aca-005165 Anolis carolinensis 75.04 0.00e+00 907.00
IUUC-Ame-011844 Astyanax mexicanus 44.64 2.00e-133 469.00
IUUC-Bta-013209 Bos taurus 95.59 0.00e+00 1207.00
IUUC-Cja-019287 Callithrix jacchus 98.69 0.00e+00 1263.00
IUUC-Cfa-021000 Canis familiaris 97.12 0.00e+00 848.00
IUUC-Cpo-022105 Cavia porcellus 92.65 0.00e+00 1159.00
IUUC-Csa-023505 Chlorocebus sabaeus 99.18 0.00e+00 1268.00
IUUC-Cho-024673 Choloepus hoffmanni 89.36 0.00e+00 1101.00
IUUC-Dre-028304 Danio rerio 45.61 5.00e-152 531.00
IUUC-Dno-029451 Dasypus novemcinctus 93.64 0.00e+00 1194.00
IUUC-Dor-030155 Dipodomys ordii 87.07 0.00e+00 1090.00
IUUC-Ete-033024 Echinops telfairi 85.27 0.00e+00 1078.00
IUUC-Eca-034120 Equus caballus 97.38 0.00e+00 1214.00
IUUC-Eeu-034621 Erinaceus europaeus 87.40 0.00e+00 1094.00
IUUC-Fca-035426 Felis catus 97.87 0.00e+00 1222.00
IUUC-Fal-037409 Ficedula albicollis 70.85 0.00e+00 884.00
IUUC-Gmo-038756 Gadus morhua 46.33 3.00e-142 498.00
IUUC-Gga-040759 Gallus gallus 71.29 0.00e+00 897.00
IUUC-Gac-041780 Gasterosteus aculeatus 47.90 4.00e-147 514.00
IUUC-Ggo-044917 Gorilla gorilla 99.51 0.00e+00 1268.00
IUUC-Itr-048426 Ictidomys tridecemlineatus 96.06 2.00e-162 564.00
IUUC-Lch-049928 Latimeria chalumnae 54.59 0.00e+00 637.00
IUUC-Loc-052892 Lepisosteus oculatus 53.28 2.00e-139 489.00
IUUC-Laf-053969 Loxodonta africana 93.33 0.00e+00 1153.00
IUUC-Mcc-055592 Macaca mulatta 99.18 0.00e+00 1268.00
IUUC-Meu-056177 Macropus eugenii 65.83 3.00e-128 452.00
IUUC-Mga-059268 Meleagris gallopavo 52.92 3.00e-153 535.00
IUUC-Mmr-060912 Microcebus murinus 98.36 0.00e+00 1231.00
IUUC-Mdo-062861 Monodelphis domestica 78.89 0.00e+00 930.00
IUUC-Mmu-063969 Mus musculus 95.74 0.00e+00 1229.00
IUUC-Mpu-065970 Mustela putorius furo 97.71 0.00e+00 1250.00
IUUC-Mlu-067698 Myotis lucifugus 96.57 0.00e+00 1223.00
IUUC-Nle-069460 Nomascus leucogenys 99.35 0.00e+00 1272.00
IUUC-Opr-070677 Ochotona princeps 94.93 0.00e+00 1194.00
IUUC-Ont-072661 Oreochromis niloticus 46.20 2.00e-155 542.00
IUUC-Oan-073683 Ornithorhynchus anatinus 81.77 0.00e+00 871.00
IUUC-Ocu-074387 Oryctolagus cuniculus 93.95 0.00e+00 1175.00
IUUC-Ola-087205 Oryzias latipes 46.70 3.00e-151 528.00
IUUC-Oga-088541 Otolemur garnettii 95.25 0.00e+00 1190.00
IUUC-Oar-089303 Ovis aries 95.10 0.00e+00 1202.00
IUUC-Ptr-091617 Pan troglodytes 99.67 0.00e+00 1270.00
IUUC-Pan-092131 Papio anubis 99.35 0.00e+00 1268.00
IUUC-Psi-092934 Pelodiscus sinensis 76.31 0.00e+00 903.00
IUUC-Pfo-097444 Poecilia formosa 45.91 1.00e-146 513.00
IUUC-Pab-098318 Pongo abelii 99.36 0.00e+00 981.00
IUUC-Pca-100096 Procavia capensis 90.09 0.00e+00 996.00
IUUC-Pva-102344 Pteropus vampyrus 88.05 0.00e+00 1099.00
IUUC-Rno-105393 Rattus norvegicus 96.07 0.00e+00 1233.00
IUUC-Sha-106830 Sarcophilus harrisii 82.54 0.00e+00 1017.00
IUUC-Sar-113635 Sorex araneus 82.43 0.00e+00 869.00
IUUC-Ssc-115928 Sus scrofa 96.74 0.00e+00 1234.00
IUUC-Tgu-116531 Taeniopygia guttata 71.13 0.00e+00 872.00
IUUC-Tru-117997 Takifugu rubripes 46.17 2.00e-148 519.00
IUUC-Tsy-119040 Tarsius syrichta 88.22 0.00e+00 1084.00
IUUC-Tni-119855 Tetraodon nigroviridis 46.09 4.00e-148 518.00
IUUC-Tbe-127588 Tupaia belangeri 81.24 0.00e+00 674.00
IUUC-Ttr-128334 Tursiops truncatus 89.27 0.00e+00 962.00
IUUC-Uma-129614 Ustilago maydis 25.51 1.50e-02 33.90
IUUC-Vpa-130561 Vicugna pacos 92.96 0.00e+00 1149.00
IUUC-Xtr-132632 Xenopus tropicalis 57.99 3.00e-176 611.00
Created Date 25-Jun-2017

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