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Tag Content
UUCD2 ID IUUC-Dre-027880
UUCD1 version UUC-DaR-01171
Ensembl Protein ID ENSDARP00000026361.8
UniProt Accession Q5BL35; SPOLA_DANRE
Genbank Protein ID AAH90815.1
Protein Name Speckle-type POZ protein-like A; HIB homolog 2
Genbank Nucleotide ID BC090815
Gene Name spopla; spopl; zgc:101524
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000010563.9 ENSDART00000011922.8 ENSDARP00000026361.8
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.20e-29 102.0 200 267
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.30e-08 31.9 299 326
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +D+ l+vgg+ef+ahk++Laa+S+vF+a+f++e+eesk k++v+i+dv+pevf++++ F+Ytgk+++ e
   Q: 200  TDCSLYVGGQEFKAHKSILAARSPVFNAMFEHEMEESK-KNRVDISDVEPEVFKEMMGFIYTGKAPNLE 267
           7*************************************.**************************9976 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfil 28
           +eN+++ l +Adl+++++Lk +a+dfi+
   Q: 299  VENVADTLILADLHSAEQLKAQAIDFIN 326
           79*************************7 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
Protein Sequence
(Fasta)
MSGVPTPPPP GEMSSGPVAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE VLKSSTFSSG 60
PNDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA KFKFSLLNAK REETKAMESQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027880|E3,BTB_3-box|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACTGCAAGC TACTGTGATG GGCTGTTTTT GAAAAGACAC AGATACACTT CAGTCTTAAA 60
TAGTGCCGAT TTAACTTAGC ACATCCACAA GGACCGTCCG AACCTTGACT TTAACATTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027880|E3,BTB_3-box|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like
PROSITE

PS50097--BTB
PS50144--MATH
Pfam

PF00651--BTB
PF00917--MATH
SMART

SM00225--BTB
SM00061--MATH
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG dre:541318
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001309 Ailuropoda melanoleuca 90.82 0.00e+00 712.00
IUUC-Apl-003864 Anas platyrhynchos 94.39 0.00e+00 753.00
IUUC-Aca-005320 Anolis carolinensis 91.58 0.00e+00 727.00
IUUC-Aly-005813 Arabidopsis lyrata 28.08 1.00e-36 147.00
IUUC-Ath-007670 Arabidopsis thaliana 28.87 6.00e-39 155.00
IUUC-Afl-008594 Aspergillus flavus 38.46 5.00e-04 37.70
IUUC-Aor-009945 Aspergillus oryzae 38.46 1.00e-04 37.70
IUUC-Bgr-012157 Blumeria graminis 36.25 4.00e-05 42.00
IUUC-Bta-013528 Bos taurus 85.97 0.00e+00 657.00
IUUC-Bci-013825 Botrytis cinerea 29.17 4.00e-07 49.30
IUUC-Bol-015218 Brassica oleracea 31.96 1.00e-44 174.00
IUUC-Bra-016833 Brassica rapa 31.69 3.00e-44 172.00
IUUC-Cja-019227 Callithrix jacchus 88.01 0.00e+00 707.00
IUUC-Cfa-020990 Canis familiaris 90.82 0.00e+00 712.00
IUUC-Cpo-021660 Cavia porcellus 91.58 0.00e+00 735.00
IUUC-Cho-024732 Choloepus hoffmanni 81.63 0.00e+00 634.00
IUUC-Dno-029399 Dasypus novemcinctus 91.33 0.00e+00 732.00
IUUC-Ete-032759 Echinops telfairi 85.46 0.00e+00 676.00
IUUC-Eca-033858 Equus caballus 91.58 0.00e+00 716.00
IUUC-Eeu-035156 Erinaceus europaeus 92.31 7.00e-175 606.00
IUUC-Fca-036500 Felis catus 91.33 0.00e+00 714.00
IUUC-Fal-037023 Ficedula albicollis 94.39 0.00e+00 753.00
IUUC-Gmo-038605 Gadus morhua 98.72 0.00e+00 805.00
IUUC-Gga-040204 Gallus gallus 94.39 0.00e+00 753.00
IUUC-Gac-042260 Gasterosteus aculeatus 98.47 0.00e+00 804.00
IUUC-Gma-043055 Glycine max 29.46 9.00e-41 160.00
IUUC-Ggo-045160 Gorilla gorilla 90.82 0.00e+00 731.00
IUUC-Hsa-045729 Homo sapiens 91.07 0.00e+00 733.00
IUUC-Hvu-047528 Hordeum vulgare 31.78 4.00e-42 165.00
IUUC-Itr-048153 Ictidomys tridecemlineatus 90.82 0.00e+00 732.00
IUUC-Lch-050036 Latimeria chalumnae 92.86 0.00e+00 712.00
IUUC-Loc-052332 Lepisosteus oculatus 94.74 0.00e+00 755.00
IUUC-Lma-053180 Leptosphaeria maculans 31.90 5.00e-09 56.20
IUUC-Laf-053691 Loxodonta africana 91.58 0.00e+00 737.00
IUUC-Mcc-055808 Macaca mulatta 90.82 0.00e+00 731.00
IUUC-Mor-057237 Magnaporthe oryzae 31.76 2.00e-09 56.20
IUUC-Mga-059990 Meleagris gallopavo 94.39 0.00e+00 753.00
IUUC-Mmr-061748 Microcebus murinus 91.33 0.00e+00 732.00
IUUC-Mmu-063522 Mus musculus 89.03 0.00e+00 716.00
IUUC-Mpu-065894 Mustela putorius furo 85.13 0.00e+00 694.00
IUUC-Mlu-067879 Myotis lucifugus 90.05 0.00e+00 707.00
IUUC-Nle-069115 Nomascus leucogenys 91.07 0.00e+00 733.00
IUUC-Ont-072569 Oreochromis niloticus 98.72 0.00e+00 805.00
IUUC-Oan-073449 Ornithorhynchus anatinus 91.07 0.00e+00 723.00
IUUC-Ocu-073817 Oryctolagus cuniculus 91.07 0.00e+00 733.00
IUUC-Obr-076340 Oryza brachyantha 30.41 2.00e-34 140.00
IUUC-Ogu-078752 Oryza glumaepatula 34.28 1.00e-37 151.00
IUUC-Olo-080948 Oryza longistaminata 30.79 3.00e-35 142.00
IUUC-Opu-084147 Oryza punctata 31.34 2.00e-36 146.00
IUUC-Oru-084463 Oryza rufipogon 31.06 5.00e-36 145.00
IUUC-Osa-085702 Oryza sativa 33.04 7.00e-41 161.00
IUUC-Ola-086485 Oryzias latipes 96.95 0.00e+00 769.00
IUUC-Oga-087982 Otolemur garnettii 85.71 0.00e+00 675.00
IUUC-Oar-089667 Ovis aries 90.82 0.00e+00 709.00
IUUC-Ptr-090729 Pan troglodytes 91.07 0.00e+00 733.00
IUUC-Pan-091988 Papio anubis 91.07 0.00e+00 732.00
IUUC-Psi-093103 Pelodiscus sinensis 94.13 0.00e+00 752.00
IUUC-Pma-094310 Petromyzon marinus 83.02 1.00e-168 585.00
IUUC-Pno-095092 Phaeosphaeria nodorum 23.26 2.00e-05 46.20
IUUC-Pfo-096279 Poecilia formosa 90.08 0.00e+00 692.00
IUUC-Pab-098431 Pongo abelii 91.07 0.00e+00 733.00
IUUC-Pca-100373 Procavia capensis 73.54 2.00e-129 455.00
IUUC-Pva-102660 Pteropus vampyrus 91.07 0.00e+00 714.00
IUUC-Pyt-104809 Pyrenophora triticirepentis 27.52 3.00e-05 42.00
IUUC-Rno-105020 Rattus norvegicus 82.08 0.00e+00 672.00
IUUC-Sha-107038 Sarcophilus harrisii 91.58 0.00e+00 735.00
IUUC-Sly-110886 Solanum lycopersicum 31.83 1.00e-32 134.00
IUUC-Stu-112678 Solanum tuberosum 31.83 2.00e-32 133.00
IUUC-Ssc-116199 Sus scrofa 85.97 0.00e+00 659.00
IUUC-Tgu-116755 Taeniopygia guttata 93.88 0.00e+00 744.00
IUUC-Tru-118288 Takifugu rubripes 93.88 0.00e+00 743.00
IUUC-Tni-119955 Tetraodon nigroviridis 94.16 0.00e+00 745.00
IUUC-Tre-122160 Trichoderma reesei 32.88 1.00e-08 53.50
IUUC-Tae-124631 Triticum aestivum 32.05 8.00e-43 167.00
IUUC-Tur-126285 Triticum urartu 34.43 4.00e-40 158.00
IUUC-Ttr-129261 Tursiops truncatus 90.82 0.00e+00 711.00
IUUC-Vpa-130728 Vicugna pacos 90.56 1.00e-174 605.00
Created Date 25-Jun-2017

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