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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046476
UUCD1 version UUC-HoS-00370
Ensembl Protein ID ENSP00000459324.1
UniProt Accession Q9H6Y7; D3DTK8; Q6XYE0; Q8NDC1; Q9Y3V1; RN167_HUMAN
Genbank Protein ID CAB43253.1; CAD38958.1; BAB15113.1; AAP34453.1; CAG33621.1; EAW90385.1; EAW90387.1; EAW90388.1; AAH10139.1
Protein Name E3 ubiquitin-protein ligase RNF167; RING finger protein 167; RING-type E3 ubiquitin transferase RNF167; RING105
Genbank Nucleotide ID AL050060; AL834284; AK025329; AY203930; CR457340; CH471108; CH471108; CH471108; BC010139
Gene Name RNF167; LP2254
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108523.15 ENST00000571816.5 ENSP00000459324.1
ENSG00000108523.15 ENST00000575400.5 ENSP00000460991.1
ENSG00000108523.15 ENST00000572382.5 ENSP00000460024.1
ENSG00000108523.15 ENST00000576965.1 ENSP00000466753.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16314844
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.70e-09 38.3 230 272
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl++++dg  ++vlpC H++h  C+  w     +++++ +CP+C+
   Q: 230  CAICLDEYEDGdkLRVLPCAHAYHSRCVDPW-----LTQTRKTCPICK 272
           ********66666******************.....8**********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.
 May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.
Protein Sequence
(Fasta)
MHPAAFPLPV VVAAVLWGAA PTRGLIRATS DHNASMDFAD LPALFGATLS QEGLQGFLVE 60
AHPDNACSPI APPPPAPVNG SVFIALLRRF DCNFDLKVLN AQKAGYGAAV VHNVNSNELL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046476|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCCCTCCA GCTCTCAGGT CCGACACCCG CTGGAAGCCG GCGCGGGCGC AGGCGCGCAG 60
CGCAAAGGCG GCCGGGAGTA AGGCGGAGCT GAAGGAGGAG CTTGATGGAA GCGTGCGAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046476|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0005737--C:cytoplasm
GO:0012505--C:endomembrane system
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045786--P:negative regulation of cell cycle
GO:0000209--P:protein polyubiquitination
KEGG hsa:26001
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001413 Ailuropoda melanoleuca 91.29 2.00e-135 475.00
IUUC-Ath-007212 Arabidopsis thaliana 32.59 4.00e-33 135.00
IUUC-Acl-008256 Aspergillus clavatus 60.42 6.00e-14 71.60
IUUC-Afl-008548 Aspergillus flavus 62.22 1.00e-13 70.90
IUUC-Afu-008977 Aspergillus fumigatus 62.22 2.00e-13 70.10
IUUC-Ang-009734 Aspergillus niger 62.22 6.00e-14 72.00
IUUC-Aor-010134 Aspergillus oryzae 62.22 1.00e-13 71.20
IUUC-Ate-010329 Aspergillus terreus 62.22 2.00e-13 70.50
IUUC-Bta-012651 Bos taurus 95.70 1.00e-129 455.00
IUUC-Bci-013726 Botrytis cinerea 55.56 1.00e-12 68.20
IUUC-Cja-018953 Callithrix jacchus 94.19 1.00e-148 519.00
IUUC-Cfa-020540 Canis familiaris 72.16 1.00e-95 343.00
IUUC-Cpo-022372 Cavia porcellus 92.75 3.00e-168 583.00
IUUC-Cre-022631 Chlamydomonas reinhardtii 27.30 3.00e-21 95.90
IUUC-Csa-023070 Chlorocebus sabaeus 94.84 4.00e-161 560.00
IUUC-Cgl-026762 Colletotrichum gloeosporioides 60.00 1.00e-13 70.90
IUUC-Cne-026954 Cryptococcus neoformans 48.44 1.00e-13 71.20
IUUC-Dre-028786 Danio rerio 53.67 3.00e-82 298.00
IUUC-Dno-028877 Dasypus novemcinctus 94.86 1.00e-169 589.00
IUUC-Dor-030128 Dipodomys ordii 81.27 6.00e-152 530.00
IUUC-Ete-033067 Echinops telfairi 77.67 5.00e-108 384.00
IUUC-Eca-033699 Equus caballus 93.99 2.00e-160 558.00
IUUC-Eeu-034819 Erinaceus europaeus 95.47 1.00e-151 529.00
IUUC-Fca-036168 Felis catus 95.65 9.00e-149 519.00
IUUC-Fox-037990 Fusarium oxysporum 60.00 3.00e-13 70.10
IUUC-Fso-038278 Fusarium solani 60.00 5.00e-13 68.90
IUUC-Ggr-039870 Gaeumannomyces graminis 55.56 1.00e-12 67.80
IUUC-Gac-041339 Gasterosteus aculeatus 55.94 3.00e-79 288.00
IUUC-Gma-043776 Glycine max 33.33 4.00e-29 122.00
IUUC-Ggo-045113 Gorilla gorilla 95.50 1.00e-164 572.00
IUUC-Itr-047953 Ictidomys tridecemlineatus 91.24 1.00e-172 598.00
IUUC-Lch-050034 Latimeria chalumnae 57.99 2.00e-96 345.00
IUUC-Loc-051914 Lepisosteus oculatus 60.22 4.00e-85 308.00
IUUC-Lma-053199 Leptosphaeria maculans 58.33 6.00e-14 72.00
IUUC-Laf-053687 Loxodonta africana 92.56 8.00e-154 536.00
IUUC-Mcc-055879 Macaca mulatta 98.71 1.00e-166 578.00
IUUC-Meu-056408 Macropus eugenii 78.26 3.00e-115 408.00
IUUC-Mor-057236 Magnaporthe oryzae 60.00 2.00e-13 70.50
IUUC-Mpo-057321 Magnaporthe poae 55.56 2.00e-12 67.40
IUUC-Mmr-060656 Microcebus murinus 95.17 7.00e-174 603.00
IUUC-Mdo-062795 Monodelphis domestica 82.87 1.00e-137 482.00
IUUC-Mmu-063722 Mus musculus 94.86 2.00e-165 575.00
IUUC-Mpu-066094 Mustela putorius furo 91.05 1.00e-145 509.00
IUUC-Mlu-067350 Myotis lucifugus 94.56 3.00e-156 544.00
IUUC-Nfi-068514 Neosartorya fischeri 62.22 2.00e-13 70.50
IUUC-Nle-069971 Nomascus leucogenys 94.86 8.00e-162 563.00
IUUC-Opr-070716 Ochotona princeps 95.96 1.00e-109 389.00
IUUC-Oan-072710 Ornithorhynchus anatinus 72.44 4.00e-69 254.00
IUUC-Ocu-074157 Oryctolagus cuniculus 93.23 2.00e-159 555.00
IUUC-Oga-089169 Otolemur garnettii 93.67 1.00e-173 602.00
IUUC-Oar-089216 Ovis aries 95.50 4.00e-159 553.00
IUUC-Ptr-091493 Pan troglodytes 95.50 1.00e-164 572.00
IUUC-Pan-092215 Papio anubis 94.52 9.00e-161 559.00
IUUC-Psi-093038 Pelodiscus sinensis 62.25 6.00e-106 377.00
IUUC-Pno-094907 Phaeosphaeria nodorum 62.22 5.00e-14 72.40
IUUC-Pfo-097514 Poecilia formosa 58.08 5.00e-80 291.00
IUUC-Pab-097739 Pongo abelii 88.06 5.00e-158 550.00
IUUC-Pop-098937 Populus trichocarpa 29.28 2.00e-26 113.00
IUUC-Pca-100609 Procavia capensis 92.49 3.00e-158 550.00
IUUC-Pva-102834 Pteropus vampyrus 93.09 1.00e-171 595.00
IUUC-Pte-104147 Pyrenophora teres 60.00 2.00e-13 70.90
IUUC-Pyt-104748 Pyrenophora triticirepentis 62.22 1.00e-13 70.90
IUUC-Rno-106080 Rattus norvegicus 91.87 1.00e-164 572.00
IUUC-Sha-106787 Sarcophilus harrisii 87.00 2.00e-133 468.00
IUUC-Spo-108205 Schizosaccharomyces pombe 41.67 9.00e-11 60.80
IUUC-Stu-112408 Solanum tuberosum 30.94 4.00e-27 115.00
IUUC-Sar-113580 Sorex araneus 80.97 3.00e-125 441.00
IUUC-Ssc-115900 Sus scrofa 95.47 4.00e-174 603.00
IUUC-Tru-118584 Takifugu rubripes 53.38 1.00e-85 310.00
IUUC-Tsy-119134 Tarsius syrichta 96.57 7.00e-97 346.00
IUUC-Tni-120357 Tetraodon nigroviridis 59.76 2.00e-86 312.00
IUUC-Tre-121885 Trichoderma reesei 57.78 1.00e-12 67.80
IUUC-Tvi-122633 Trichoderma virens 57.78 1.00e-12 67.80
IUUC-Tae-123096 Triticum aestivum 33.46 1.00e-30 127.00
IUUC-Tme-126894 Tuber melanosporum 40.78 1.00e-12 68.20
IUUC-Tbe-127812 Tupaia belangeri 96.74 9.00e-131 459.00
IUUC-Ttr-128409 Tursiops truncatus 96.04 6.00e-134 469.00
IUUC-Vvi-131036 Vitis vinifera 31.17 1.00e-30 127.00
IUUC-Xma-133568 Xiphophorus maculatus 55.02 3.00e-75 275.00
Created Date 25-Jun-2017

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