iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012522

Ensembl Protein ID

ENSBTAP00000010497.4

UniProt Accession

F1MMY4; F1MMY4_BOVIN

Genbank Protein ID

ENSBTAP00000010497

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

DAAA02018575

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000007986.5	ENSBTAT00000010497.4	ENSBTAP00000010497.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.10e-14	52.6	836	876

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 836  WCFVCSKGGS----LLCCESCPAAFHPDCLSIE----MPDGS-WFCNDCR 876
           8*********....*******************....9***8.******8 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

LFLTLQCSET EAPRLMKCVK MKQAPEVLGS ANGKTPSCDV SRECSVFLSK AQLSAGLQDG 60
VVQKFNGHDA LPFIPAERLK DLTSRVFNGE PGAHDAKLRF ESQEVKGLGT PPHTTPVKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTTCTAA CGCTGCAGTG TTCTGAGACG GAGGCACCTA GGCTGAATGG AATTCAGCGT 60
CAGGAAAAGC CCTCTTTCTG CTCCAAAGGT GGTGAAGTGC GTGAAGATGA AGCAGGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	87.66	0.00e+00	2325.00
IUUC-Apl-003677	Anas platyrhynchos	77.00	0.00e+00	2034.00
IUUC-Aca-004278	Anolis carolinensis	74.86	0.00e+00	1379.00
IUUC-Ame-011932	Astyanax mexicanus	70.81	0.00e+00	1025.00
IUUC-Cja-018908	Callithrix jacchus	85.72	0.00e+00	2226.00
IUUC-Cfa-020894	Canis familiaris	86.57	0.00e+00	2363.00
IUUC-Cpo-021982	Cavia porcellus	84.11	0.00e+00	2237.00
IUUC-Csa-023807	Chlorocebus sabaeus	86.33	0.00e+00	2259.00
IUUC-Cho-024405	Choloepus hoffmanni	72.55	0.00e+00	718.00
IUUC-Csv-026298	Ciona savignyi	38.93	4.00e-57	215.00
IUUC-Dre-027492	Danio rerio	71.04	0.00e+00	1064.00
IUUC-Dno-030020	Dasypus novemcinctus	84.74	0.00e+00	1991.00
IUUC-Dor-031103	Dipodomys ordii	79.09	0.00e+00	2023.00
IUUC-Ete-032488	Echinops telfairi	78.77	0.00e+00	2023.00
IUUC-Eca-034066	Equus caballus	87.16	0.00e+00	2353.00
IUUC-Eeu-035199	Erinaceus europaeus	70.40	0.00e+00	741.00
IUUC-Fca-035434	Felis catus	85.01	0.00e+00	1958.00
IUUC-Fal-037113	Ficedula albicollis	75.59	0.00e+00	2043.00
IUUC-Gmo-039686	Gadus morhua	69.07	0.00e+00	1011.00
IUUC-Gga-040273	Gallus gallus	75.28	0.00e+00	2009.00
IUUC-Gac-042123	Gasterosteus aculeatus	50.30	0.00e+00	1222.00
IUUC-Ggo-044643	Gorilla gorilla	86.30	0.00e+00	2280.00
IUUC-Hsa-046380	Homo sapiens	86.23	0.00e+00	2248.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	88.64	0.00e+00	1395.00
IUUC-Lch-050217	Latimeria chalumnae	65.29	0.00e+00	1704.00
IUUC-Lpe-051661	Leersia perrieri	29.70	2.00e-12	68.60
IUUC-Loc-052766	Lepisosteus oculatus	59.02	0.00e+00	1276.00
IUUC-Laf-053780	Loxodonta africana	84.96	0.00e+00	2300.00
IUUC-Mcc-054928	Macaca mulatta	86.33	0.00e+00	2284.00
IUUC-Meu-056184	Macropus eugenii	73.01	0.00e+00	769.00
IUUC-Mga-059576	Meleagris gallopavo	76.01	0.00e+00	2006.00
IUUC-Mmr-061045	Microcebus murinus	85.31	0.00e+00	2294.00
IUUC-Mdo-062576	Monodelphis domestica	79.96	0.00e+00	2127.00
IUUC-Mmu-063640	Mus musculus	84.52	0.00e+00	2219.00
IUUC-Mac-065303	Musa acuminata	29.22	4.00e-11	63.20
IUUC-Mpu-066512	Mustela putorius furo	86.87	0.00e+00	2315.00
IUUC-Mlu-067280	Myotis lucifugus	79.54	0.00e+00	1077.00
IUUC-Nle-069896	Nomascus leucogenys	86.52	0.00e+00	2173.00
IUUC-Ont-072197	Oreochromis niloticus	72.70	0.00e+00	1025.00
IUUC-Oan-072724	Ornithorhynchus anatinus	77.58	0.00e+00	1342.00
IUUC-Ocu-074758	Oryctolagus cuniculus	81.86	0.00e+00	2161.00
IUUC-Ogl-077641	Oryza glaberrima	27.12	3.00e-10	59.30
IUUC-Oin-079557	Oryza indica	27.75	5.00e-10	58.50
IUUC-Olo-080702	Oryza longistaminata	42.66	2.00e-44	174.00
IUUC-Opu-083371	Oryza punctata	41.88	2.00e-46	181.00
IUUC-Osa-085353	Oryza sativa	27.12	3.00e-10	59.30
IUUC-Oga-088702	Otolemur garnettii	85.58	0.00e+00	1976.00
IUUC-Oar-089736	Ovis aries	87.69	0.00e+00	2092.00
IUUC-Ptr-091055	Pan troglodytes	86.23	0.00e+00	2245.00
IUUC-Pan-092752	Papio anubis	91.72	0.00e+00	1379.00
IUUC-Psi-093620	Pelodiscus sinensis	78.03	0.00e+00	2060.00
IUUC-Pfo-097464	Poecilia formosa	51.24	0.00e+00	1205.00
IUUC-Pab-098051	Pongo abelii	86.78	0.00e+00	2270.00
IUUC-Pop-099927	Populus trichocarpa	30.96	9.00e-13	69.30
IUUC-Pca-100273	Procavia capensis	84.68	0.00e+00	2251.00
IUUC-Ppe-101635	Prunus persica	28.87	2.00e-11	64.30
IUUC-Pva-102473	Pteropus vampyrus	78.15	0.00e+00	1908.00
IUUC-Rno-105056	Rattus norvegicus	84.68	0.00e+00	2250.00
IUUC-Sha-107494	Sarcophilus harrisii	80.45	0.00e+00	2120.00
IUUC-Sar-113310	Sorex araneus	87.17	0.00e+00	1814.00
IUUC-Ssc-116344	Sus scrofa	87.01	0.00e+00	2304.00
IUUC-Tgu-116786	Taeniopygia guttata	77.05	0.00e+00	2042.00
IUUC-Tru-117638	Takifugu rubripes	50.22	0.00e+00	1230.00
IUUC-Tsy-118937	Tarsius syrichta	89.13	0.00e+00	1466.00
IUUC-Tni-120452	Tetraodon nigroviridis	52.91	0.00e+00	1160.00
IUUC-Tae-125237	Triticum aestivum	29.45	2.00e-07	49.30
IUUC-Tbe-127291	Tupaia belangeri	82.61	0.00e+00	1459.00
IUUC-Ttr-129017	Tursiops truncatus	85.46	0.00e+00	1792.00
IUUC-Xtr-132673	Xenopus tropicalis	66.11	0.00e+00	1744.00
IUUC-Xma-133695	Xiphophorus maculatus	73.00	0.00e+00	1005.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence