iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133389

Ensembl Protein ID

ENSXMAP00000008167.1

UniProt Accession

M4A123; M4A123_XIPMA

Genbank Protein ID

ENSXMAP00000008167

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01001053

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000008095.1	ENSXMAT00000008177.1	ENSXMAP00000008167.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.30e-101	337.8	723	1046

Active Site

Position(s)	Description	Evidence
1015	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l++kel +p++g+f+y e+++  ++  ++      e ++lF+++G+++g+a+++  +++l
   Q: 723  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFSHKTF-----EDFDLFNLIGVICGLAIYNFTIVEL 804
           78999*********************************************9987766.....79*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k +ledl e++p++ +sl+e++++ae+die++ ++l+f+++e+++g t++ eL+p+Geni+V+++N++e+v+++
   Q: 805  NFPLALYKKLLKRKPTLEDLRELMPDVGRSLQELLDYAEDDIEDA-FCLNFTITEDNYGATEVLELVPNGENINVNKSNRQEFVDAY 890
           ********************************************8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y +++++++ +e f++Gf++v+  ++l+lF+++el+ +i G++++d+ +l+k t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 891  VDYVFNKSVASLFEGFYSGFHKVCGGRVLDLFQPSELQAMIIGNTNYDWTELEKSTEYKGEYWAEHPTIKLFWEVFHELPLEKKKQF 977
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Yss e+l+ekLl Ai++++gF+l
   Q: 978  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEHYLPVAHTCFNLLDLPKYSSIETLREKLLHAIDHNQGFNL 1046
           *******************...6666658889**************************************87 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRRCDF FHGKRVNDVG CGRKHTAFLL DDGTVYTCGC 60
NDLGQLGHDK SRKKPGWVVA LDAQIIVALS CGESHTLALN DKGQVFSWGL GSDGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTATATTGA CACACTACAT TAATAGCTCC GTACAGCGGC TGTTGACAGG TCTTTTGGAG 60
ATGAGTGAAA GATTTAGTGT CATCCATGAG ATTGTTAGCT TTCCACGGTA ATCTCTGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

xma:102228169

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	73.04	0.00e+00	1520.00
IUUC-Apl-003295	Anas platyrhynchos	72.56	0.00e+00	1554.00
IUUC-Aca-004336	Anolis carolinensis	73.22	0.00e+00	1572.00
IUUC-Ago-007908	Ashbya gossypii	32.58	1.00e-69	258.00
IUUC-Ame-010768	Astyanax mexicanus	76.90	0.00e+00	1649.00
IUUC-Bta-013279	Bos taurus	72.94	0.00e+00	1517.00
IUUC-Cel-018150	Caenorhabditis elegans	34.81	2.00e-158	553.00
IUUC-Cja-019023	Callithrix jacchus	73.20	0.00e+00	1517.00
IUUC-Cfa-021074	Canis familiaris	73.04	0.00e+00	1519.00
IUUC-Cpo-021461	Cavia porcellus	71.39	0.00e+00	1478.00
IUUC-Csa-024261	Chlorocebus sabaeus	73.04	0.00e+00	1514.00
IUUC-Cin-025232	Ciona intestinalis	43.19	0.00e+00	832.00
IUUC-Cme-027151	Cyanidioschyzon merolae	29.81	3.00e-106	380.00
IUUC-Dre-028829	Danio rerio	76.90	0.00e+00	1623.00
IUUC-Dno-029445	Dasypus novemcinctus	70.72	0.00e+00	1212.00
IUUC-Dor-030158	Dipodomys ordii	79.52	0.00e+00	733.00
IUUC-Dme-032103	Drosophila melanogaster	44.82	0.00e+00	887.00
IUUC-Ete-033072	Echinops telfairi	66.16	0.00e+00	1341.00
IUUC-Eca-033317	Equus caballus	72.37	0.00e+00	1506.00
IUUC-Fca-035682	Felis catus	73.59	0.00e+00	1526.00
IUUC-Fal-036969	Ficedula albicollis	71.70	0.00e+00	1542.00
IUUC-Gmo-038671	Gadus morhua	79.62	0.00e+00	1711.00
IUUC-Gga-041174	Gallus gallus	72.25	0.00e+00	1553.00
IUUC-Gac-042600	Gasterosteus aculeatus	83.29	0.00e+00	1742.00
IUUC-Ggo-044589	Gorilla gorilla	73.13	0.00e+00	1535.00
IUUC-Hsa-046772	Homo sapiens	73.04	0.00e+00	1529.00
IUUC-Kpa-049152	Komagataella pastoris	37.86	2.00e-69	257.00
IUUC-Lch-050147	Latimeria chalumnae	71.37	0.00e+00	1261.00
IUUC-Loc-052684	Lepisosteus oculatus	76.44	0.00e+00	1604.00
IUUC-Laf-053844	Loxodonta africana	73.32	0.00e+00	1521.00
IUUC-Mcc-055531	Macaca mulatta	71.32	0.00e+00	1500.00
IUUC-Mga-060151	Meleagris gallopavo	70.04	0.00e+00	1253.00
IUUC-Mmr-060954	Microcebus murinus	73.23	0.00e+00	1518.00
IUUC-Mdo-062246	Monodelphis domestica	72.51	0.00e+00	1404.00
IUUC-Mmu-063369	Mus musculus	73.50	0.00e+00	1561.00
IUUC-Mpu-065936	Mustela putorius furo	72.96	0.00e+00	1390.00
IUUC-Mlu-067326	Myotis lucifugus	72.33	0.00e+00	1478.00
IUUC-Nle-069453	Nomascus leucogenys	73.78	0.00e+00	1522.00
IUUC-Ont-071720	Oreochromis niloticus	84.81	0.00e+00	1795.00
IUUC-Oan-073464	Ornithorhynchus anatinus	72.32	0.00e+00	1403.00
IUUC-Ocu-074207	Oryctolagus cuniculus	70.69	0.00e+00	1373.00
IUUC-Ola-086762	Oryzias latipes	84.19	0.00e+00	1729.00
IUUC-Oga-088435	Otolemur garnettii	73.60	0.00e+00	1526.00
IUUC-Oar-089233	Ovis aries	73.04	0.00e+00	1518.00
IUUC-Ptr-091368	Pan troglodytes	73.32	0.00e+00	1535.00
IUUC-Pan-092300	Papio anubis	73.04	0.00e+00	1514.00
IUUC-Psi-093406	Pelodiscus sinensis	72.67	0.00e+00	1564.00
IUUC-Pma-094113	Petromyzon marinus	66.79	0.00e+00	1083.00
IUUC-Pfo-097021	Poecilia formosa	95.61	0.00e+00	2059.00
IUUC-Pab-098327	Pongo abelii	73.23	0.00e+00	1534.00
IUUC-Pva-102909	Pteropus vampyrus	64.81	0.00e+00	1263.00
IUUC-Rno-105457	Rattus norvegicus	73.32	0.00e+00	1563.00
IUUC-Sha-106632	Sarcophilus harrisii	73.02	0.00e+00	1542.00
IUUC-Sar-113679	Sorex araneus	62.64	0.00e+00	801.00
IUUC-Tgu-116849	Taeniopygia guttata	68.52	0.00e+00	1451.00
IUUC-Tru-118206	Takifugu rubripes	80.60	0.00e+00	1659.00
IUUC-Tsy-119521	Tarsius syrichta	60.22	0.00e+00	1184.00
IUUC-Tni-120233	Tetraodon nigroviridis	80.42	0.00e+00	1649.00
IUUC-Tbe-127941	Tupaia belangeri	59.78	0.00e+00	1023.00
IUUC-Vpa-130448	Vicugna pacos	72.85	0.00e+00	1519.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence