iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117078

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01010086

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000010653.1	ENSTGUT00000011118.1	ENSTGUP00000011003.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-122	406.6	1235	1567

Active Site

Position(s)	Description	Evidence
1535	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1235 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1320
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1321 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1403
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1404 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1490
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1491 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1567
           **************************************************************************985 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

EEMASSAREH LLFVRRRNPQ LRYTLSPENL QSLASQGTMP ENMNLQRANS DTDLVTSDSR 60
SSLTASMYEY TLGQSQNLII FWDIKEEVDP TDWIGLYHID ENSPANFWDS KNRGVTGTQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAGATGG CCAGCTCAGC CCGAGAACAC CTGCTCTTCG TGCGCCGTCG CAACCCGCAG 60
CTCCGGTACA CCCTGAGCCC CGAGAACCTG CAGAGTTTGG CCTCCCAGGG CACCATGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	84.15	0.00e+00	2630.00
IUUC-Apl-003935	Anas platyrhynchos	92.92	0.00e+00	2897.00
IUUC-Aca-004558	Anolis carolinensis	86.07	0.00e+00	2671.00
IUUC-Ame-010893	Astyanax mexicanus	88.24	0.00e+00	1303.00
IUUC-Bta-013093	Bos taurus	94.72	0.00e+00	1558.00
IUUC-Cja-019651	Callithrix jacchus	84.54	0.00e+00	2521.00
IUUC-Cfa-021232	Canis familiaris	97.74	0.00e+00	1607.00
IUUC-Cpo-021770	Cavia porcellus	82.60	0.00e+00	2586.00
IUUC-Csa-023970	Chlorocebus sabaeus	85.56	0.00e+00	2635.00
IUUC-Cho-024512	Choloepus hoffmanni	78.85	0.00e+00	2330.00
IUUC-Csv-026127	Ciona savignyi	72.27	4.00e-155	540.00
IUUC-Dre-028275	Danio rerio	85.87	0.00e+00	1478.00
IUUC-Dno-029963	Dasypus novemcinctus	84.29	0.00e+00	2471.00
IUUC-Dor-030282	Dipodomys ordii	76.50	0.00e+00	1636.00
IUUC-Dme-032217	Drosophila melanogaster	71.49	0.00e+00	654.00
IUUC-Ete-033132	Echinops telfairi	81.40	0.00e+00	1236.00
IUUC-Eca-033978	Equus caballus	84.48	0.00e+00	2618.00
IUUC-Eeu-035278	Erinaceus europaeus	58.98	0.00e+00	1075.00
IUUC-Fca-036157	Felis catus	85.91	0.00e+00	2615.00
IUUC-Fal-037110	Ficedula albicollis	95.45	0.00e+00	2623.00
IUUC-Gmo-039291	Gadus morhua	73.59	0.00e+00	1155.00
IUUC-Gga-040821	Gallus gallus	94.28	0.00e+00	2898.00
IUUC-Gac-042181	Gasterosteus aculeatus	84.60	0.00e+00	1427.00
IUUC-Ggo-044862	Gorilla gorilla	85.30	0.00e+00	2521.00
IUUC-Hsa-046219	Homo sapiens	85.56	0.00e+00	2668.00
IUUC-Lch-050526	Latimeria chalumnae	79.33	0.00e+00	2424.00
IUUC-Loc-052648	Lepisosteus oculatus	87.91	0.00e+00	1518.00
IUUC-Laf-054005	Loxodonta africana	85.25	0.00e+00	2641.00
IUUC-Mcc-055314	Macaca mulatta	85.56	0.00e+00	2635.00
IUUC-Meu-056356	Macropus eugenii	62.49	0.00e+00	988.00
IUUC-Mga-060074	Meleagris gallopavo	93.31	0.00e+00	2778.00
IUUC-Mmr-061526	Microcebus murinus	85.58	0.00e+00	2624.00
IUUC-Mdo-063017	Monodelphis domestica	86.15	0.00e+00	2609.00
IUUC-Mmu-064165	Mus musculus	84.29	0.00e+00	2580.00
IUUC-Mpu-065835	Mustela putorius furo	94.14	0.00e+00	1551.00
IUUC-Mlu-067709	Myotis lucifugus	82.06	0.00e+00	2538.00
IUUC-Nle-069308	Nomascus leucogenys	85.50	0.00e+00	2630.00
IUUC-Opr-070330	Ochotona princeps	72.87	0.00e+00	2118.00
IUUC-Ont-071345	Oreochromis niloticus	86.70	0.00e+00	1443.00
IUUC-Ocu-074775	Oryctolagus cuniculus	83.83	0.00e+00	2331.00
IUUC-Ola-087225	Oryzias latipes	82.27	0.00e+00	1357.00
IUUC-Oga-088177	Otolemur garnettii	82.75	0.00e+00	2564.00
IUUC-Oar-089452	Ovis aries	85.35	0.00e+00	2630.00
IUUC-Ptr-090806	Pan troglodytes	85.63	0.00e+00	2642.00
IUUC-Pan-091838	Papio anubis	85.23	0.00e+00	2512.00
IUUC-Psi-094090	Pelodiscus sinensis	89.22	0.00e+00	2749.00
IUUC-Pfo-096520	Poecilia formosa	65.84	0.00e+00	1932.00
IUUC-Pab-098405	Pongo abelii	85.56	0.00e+00	2637.00
IUUC-Pca-100441	Procavia capensis	78.72	0.00e+00	1977.00
IUUC-Pva-102324	Pteropus vampyrus	97.24	0.00e+00	1601.00
IUUC-Rno-105943	Rattus norvegicus	83.08	0.00e+00	2638.00
IUUC-Sha-106985	Sarcophilus harrisii	83.09	0.00e+00	2184.00
IUUC-Sar-113505	Sorex araneus	93.96	0.00e+00	1517.00
IUUC-Ssc-115439	Sus scrofa	79.57	0.00e+00	1634.00
IUUC-Tru-118671	Takifugu rubripes	84.28	0.00e+00	1447.00
IUUC-Tni-120619	Tetraodon nigroviridis	85.98	0.00e+00	1424.00
IUUC-Tbe-127975	Tupaia belangeri	81.29	0.00e+00	2109.00
IUUC-Ttr-128469	Tursiops truncatus	78.73	0.00e+00	2356.00
IUUC-Vpa-130498	Vicugna pacos	75.68	0.00e+00	2155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence