iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089116

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03042142

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000015369.2	ENSOGAT00000015378.2	ENSOGAP00000013765.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-130	435.0	399	731

Active Site

Position(s)	Description	Evidence
700	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 399  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 486
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 487  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 571
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 572  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNVVKWFWKAVEFFDEERRARLLQFV 659
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 660  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 731
           **********************************************************************76 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

TVLCAKNLVK KDFFRLPDPF AKVVVDGSGQ CHSTDTVKNT LDPKWNQHYD LYIGKSDSVT 60
ISVWNHKKIH KKQGAGFLGC VRLLSNAINR LKDTGYQRLD LCKLGPNDND TVRGQIVGKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTACAGTA CTCTGTGCAA AAAACTTGGT GAAAAAGGAT TTTTTCCGTA AGTAAATTAA 60
CTTTAAATGT AAATCTTGAA TGTTCTGTAT AGGTTTTTTT TTCATAGTAT TTTAAGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	96.17	0.00e+00	1436.00
IUUC-Apl-003513	Anas platyrhynchos	94.14	0.00e+00	1417.00
IUUC-Aca-005358	Anolis carolinensis	93.77	0.00e+00	1411.00
IUUC-Ame-011320	Astyanax mexicanus	85.07	0.00e+00	1306.00
IUUC-Bta-013399	Bos taurus	95.90	0.00e+00	1428.00
IUUC-Cja-019355	Callithrix jacchus	95.77	0.00e+00	1431.00
IUUC-Cpo-022200	Cavia porcellus	96.04	0.00e+00	1434.00
IUUC-Cho-024804	Choloepus hoffmanni	100.00	0.00e+00	648.00
IUUC-Cin-025126	Ciona intestinalis	65.33	0.00e+00	941.00
IUUC-Csv-026339	Ciona savignyi	63.52	0.00e+00	975.00
IUUC-Dre-027650	Danio rerio	87.18	0.00e+00	1349.00
IUUC-Dno-029534	Dasypus novemcinctus	95.90	0.00e+00	1433.00
IUUC-Ete-032715	Echinops telfairi	91.10	0.00e+00	1343.00
IUUC-Eca-033580	Equus caballus	96.17	0.00e+00	1436.00
IUUC-Eeu-034945	Erinaceus europaeus	93.83	0.00e+00	1327.00
IUUC-Fal-037275	Ficedula albicollis	93.89	0.00e+00	1406.00
IUUC-Gga-041060	Gallus gallus	90.91	0.00e+00	1343.00
IUUC-Gac-041295	Gasterosteus aculeatus	88.77	0.00e+00	1341.00
IUUC-Hsa-046726	Homo sapiens	95.90	0.00e+00	1432.00
IUUC-Lch-050026	Latimeria chalumnae	92.14	0.00e+00	1381.00
IUUC-Loc-051760	Lepisosteus oculatus	85.70	0.00e+00	1316.00
IUUC-Laf-053753	Loxodonta africana	96.04	0.00e+00	1436.00
IUUC-Mcc-054815	Macaca mulatta	95.63	0.00e+00	1429.00
IUUC-Meu-056436	Macropus eugenii	83.93	0.00e+00	933.00
IUUC-Mmr-060806	Microcebus murinus	96.17	0.00e+00	1435.00
IUUC-Mdo-062805	Monodelphis domestica	93.85	0.00e+00	1400.00
IUUC-Mmu-064034	Mus musculus	95.63	0.00e+00	1428.00
IUUC-Mpu-066762	Mustela putorius furo	96.17	0.00e+00	1435.00
IUUC-Mlu-066981	Myotis lucifugus	96.04	0.00e+00	1434.00
IUUC-Nle-069804	Nomascus leucogenys	95.90	0.00e+00	1432.00
IUUC-Opr-070591	Ochotona princeps	90.41	0.00e+00	1333.00
IUUC-Ont-071239	Oreochromis niloticus	89.45	0.00e+00	1347.00
IUUC-Oan-072699	Ornithorhynchus anatinus	92.18	0.00e+00	1405.00
IUUC-Ocu-074913	Oryctolagus cuniculus	96.17	0.00e+00	1437.00
IUUC-Ola-086597	Oryzias latipes	82.88	0.00e+00	1232.00
IUUC-Oar-089366	Ovis aries	95.77	0.00e+00	1428.00
IUUC-Ptr-091382	Pan troglodytes	95.90	0.00e+00	1432.00
IUUC-Psi-093298	Pelodiscus sinensis	94.41	0.00e+00	1397.00
IUUC-Pma-094354	Petromyzon marinus	71.09	0.00e+00	1058.00
IUUC-Pfo-096071	Poecilia formosa	87.02	0.00e+00	1336.00
IUUC-Pab-098682	Pongo abelii	95.90	0.00e+00	1434.00
IUUC-Pca-100516	Procavia capensis	90.41	0.00e+00	639.00
IUUC-Pva-102754	Pteropus vampyrus	94.93	0.00e+00	1399.00
IUUC-Rno-105600	Rattus norvegicus	94.97	0.00e+00	1229.00
IUUC-Sha-107144	Sarcophilus harrisii	93.54	0.00e+00	1296.00
IUUC-Sar-113122	Sorex araneus	84.79	0.00e+00	1218.00
IUUC-Tgu-117112	Taeniopygia guttata	93.62	0.00e+00	1405.00
IUUC-Tru-118497	Takifugu rubripes	86.02	0.00e+00	1286.00
IUUC-Tni-120781	Tetraodon nigroviridis	85.74	0.00e+00	1120.00
IUUC-Tme-126897	Tuber melanosporum	39.03	6.00e-148	518.00
IUUC-Tbe-127371	Tupaia belangeri	85.91	0.00e+00	1138.00
IUUC-Ttr-129305	Tursiops truncatus	87.80	0.00e+00	1222.00
IUUC-Vpa-130591	Vicugna pacos	85.62	0.00e+00	1238.00
IUUC-Xtr-132979	Xenopus tropicalis	74.83	0.00e+00	1049.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence