iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009176

Ensembl Protein ID

CADANIAP00002251

UniProt Accession

C8VT87; C8VT87_EMENI

Genbank Protein ID

CBF89472.1

Protein Name

Ubiquitin-protein ligase (Hul4), putative (AFU_orthologue AFUA_1G04640)

Genbank Nucleotide ID

BN001308

Gene Name

ANIA_00444

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00002251	CADANIAT00002251	CADANIAP00002251

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-78	262.3	753	1089

Active Site

Position(s)	Description	Evidence
1058	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           ++++kk l++ fvgEeg+d+gG+ +e++ ll++e+++p  glf y+e+++++ + np       e  + F ++G++lg+a++++ +ld+ l
   Q: 753  PEEMKKGLRIGFVGEEGVDAGGLRKEWFLLLVREVFDPHHGLFIYDEDSRYC-YFNPYCL----ESSEQFFLVGVVLGLAIYNSIILDIAL 838
           6789******************************************999888.6699887....5778888******************** PP
   S: 93   sksfyklllgk........klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           +++ +k+ll          +l+ +dl+e  p l++ l  ++e  e d+ e+ ++ tf ++ + +ge+ ++ L+pgGe+ pVtn+N++e+v+
   Q: 839  PPFAFKKLLAGapqttgpqPLTTQDLAEYRPVLARGLRALLEF-EGDVAET-FCHTFVADVDRYGEVVSVPLCPGGEKKPVTNANRREFVD 927
           ********999888888889*********************99.6788887.*************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky...kggytedspaiqwFwevleefsseerk 262
           l v+y+l + +++q+e fr+Gf +v+  + lslF++ee+ell+ G+ e++dv++l++ ++y        e+ p+++wFwe +e+ + e ++
   Q: 928  LFVHYHLDTAVARQFEPFRRGFFSVCGGNALSLFRPEEIELLVRGSdEQLDVKSLRAVATYlnwGTPKPESVPVVRWFWEYFERANPEAQR 1018
           **********************************************9************998543334578899***************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++L FvT+s+r+P+ G  +l+ +l+++ +  +  r+P+++TCfn+L L +Y++ e++++ L  A+ +++gF+l
   Q: 1019 KILSFVTSSDRIPAMGATSLNIQLICLGD--DSPRFPTAHTCFNRLGLYRYKTREKFERLLSEAVLNSEGFGL 1089
           ***********************999999..779*************************************98 PP

Organism

Aspergillus nidulans

Protein Sequence
(Fasta)

MPSLAAHKPS AHQSASSAGV QPGTSPIPVP IVGGRSPNRL RYGEPRVTGA PISPPSGPTF 60
HRGHSRSISQ PFASALSGVG KRRNKSISVE ADVDTDDDDE DDDDIYIPNP NPISSSPRKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGTCGC TGGCTGCGCA TAAACCGTCG GCCCATCAAT CCGCGAGTTC GGCCGGCGTC 60
CAACCTGGCA CAAGCCCCAT TCCCGTGCCT ATAGTTGGGG GTCGCTCCCC AAATCGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	35.48	8.00e-97	346.00
IUUC-Atr-003144	Amborella trichopoda	39.82	2.00e-86	310.00
IUUC-Apl-003589	Anas platyrhynchos	34.39	1.00e-88	318.00
IUUC-Aca-004350	Anolis carolinensis	40.18	2.00e-91	328.00
IUUC-Ago-007908	Ashbya gossypii	33.79	4.00e-94	337.00
IUUC-Acl-008288	Aspergillus clavatus	72.68	0.00e+00	944.00
IUUC-Afl-008402	Aspergillus flavus	76.25	0.00e+00	889.00
IUUC-Afu-008762	Aspergillus fumigatus	74.67	0.00e+00	953.00
IUUC-Ang-009791	Aspergillus niger	75.87	0.00e+00	922.00
IUUC-Aor-009921	Aspergillus oryzae	75.75	0.00e+00	882.00
IUUC-Ate-010295	Aspergillus terreus	76.74	0.00e+00	962.00
IUUC-Ame-011166	Astyanax mexicanus	38.70	2.00e-82	298.00
IUUC-Bgr-011981	Blumeria graminis	60.16	0.00e+00	749.00
IUUC-Bta-012945	Bos taurus	40.62	5.00e-94	337.00
IUUC-Bci-013697	Botrytis cinerea	59.63	0.00e+00	712.00
IUUC-Cel-018150	Caenorhabditis elegans	31.21	2.00e-53	202.00
IUUC-Cja-019263	Callithrix jacchus	39.07	6.00e-90	323.00
IUUC-Cfa-020486	Canis familiaris	35.55	1.00e-97	348.00
IUUC-Cpo-021755	Cavia porcellus	35.66	2.00e-97	348.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	43.67	1.00e-60	224.00
IUUC-Csa-023378	Chlorocebus sabaeus	32.94	1.00e-80	292.00
IUUC-Cho-025059	Choloepus hoffmanni	31.15	1.00e-71	263.00
IUUC-Cin-025643	Ciona intestinalis	32.16	9.00e-69	253.00
IUUC-Csv-026282	Ciona savignyi	31.62	2.00e-62	232.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	58.31	0.00e+00	694.00
IUUC-Cme-027151	Cyanidioschyzon merolae	37.96	5.00e-77	281.00
IUUC-Dre-028551	Danio rerio	39.33	5.00e-90	323.00
IUUC-Dno-029497	Dasypus novemcinctus	39.74	5.00e-92	330.00
IUUC-Dor-030158	Dipodomys ordii	36.60	5.00e-67	248.00
IUUC-Dse-031239	Dothistroma septosporum	44.60	0.00e+00	734.00
IUUC-Dme-032035	Drosophila melanogaster	34.01	9.00e-70	256.00
IUUC-Ete-032902	Echinops telfairi	33.39	2.00e-86	311.00
IUUC-Eca-033678	Equus caballus	35.71	3.00e-98	351.00
IUUC-Eeu-035109	Erinaceus europaeus	32.25	2.00e-72	265.00
IUUC-Fca-035590	Felis catus	36.05	7.00e-99	353.00
IUUC-Fal-036747	Ficedula albicollis	32.51	4.00e-80	291.00
IUUC-Fox-037941	Fusarium oxysporum	58.77	0.00e+00	733.00
IUUC-Fso-038388	Fusarium solani	58.85	0.00e+00	726.00
IUUC-Gmo-039553	Gadus morhua	39.96	2.00e-78	285.00
IUUC-Ggr-040110	Gaeumannomyces graminis	41.45	0.00e+00	759.00
IUUC-Gga-040406	Gallus gallus	34.55	2.00e-91	328.00
IUUC-Gac-042141	Gasterosteus aculeatus	34.05	8.00e-88	316.00
IUUC-Ggo-045504	Gorilla gorilla	38.63	2.00e-89	322.00
IUUC-Hsa-045786	Homo sapiens	38.63	2.00e-89	322.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	32.76	2.00e-77	281.00
IUUC-Kpa-049152	Komagataella pastoris	32.48	6.00e-93	333.00
IUUC-Lch-050197	Latimeria chalumnae	32.76	3.00e-82	298.00
IUUC-Loc-052173	Lepisosteus oculatus	35.71	1.00e-100	359.00
IUUC-Laf-054017	Loxodonta africana	39.96	3.00e-92	331.00
IUUC-Mcc-055713	Macaca mulatta	39.07	6.00e-90	323.00
IUUC-Meu-056061	Macropus eugenii	32.35	7.00e-78	283.00
IUUC-Mor-057045	Magnaporthe oryzae	42.75	0.00e+00	814.00
IUUC-Mla-059187	Melampsora laricipopulina	43.24	6.00e-93	332.00
IUUC-Mga-059884	Meleagris gallopavo	39.30	3.00e-85	307.00
IUUC-Mmr-061344	Microcebus murinus	35.38	4.00e-97	347.00
IUUC-Mdo-062653	Monodelphis domestica	40.40	3.00e-92	331.00
IUUC-Mmu-063775	Mus musculus	40.53	1.00e-93	335.00
IUUC-Mpu-066069	Mustela putorius furo	35.71	3.00e-98	350.00
IUUC-Mlu-067925	Myotis lucifugus	41.50	3.00e-95	340.00
IUUC-Nfi-068439	Neosartorya fischeri	73.90	0.00e+00	940.00
IUUC-Ncr-068903	Neurospora crassa	44.25	0.00e+00	767.00
IUUC-Nle-070046	Nomascus leucogenys	34.65	3.00e-93	334.00
IUUC-Opr-070570	Ochotona princeps	29.52	1.00e-60	226.00
IUUC-Ont-072126	Oreochromis niloticus	34.55	3.00e-93	334.00
IUUC-Oan-072933	Ornithorhynchus anatinus	39.38	9.00e-91	325.00
IUUC-Ocu-073800	Oryctolagus cuniculus	39.51	4.00e-90	323.00
IUUC-Ola-086988	Oryzias latipes	35.04	9.00e-93	332.00
IUUC-Oga-088117	Otolemur garnettii	39.96	7.00e-91	326.00
IUUC-Oar-089371	Ovis aries	40.62	1.00e-93	335.00
IUUC-Ptr-090551	Pan troglodytes	38.85	2.00e-89	322.00
IUUC-Pan-092067	Papio anubis	39.07	6.00e-90	323.00
IUUC-Psi-092963	Pelodiscus sinensis	40.18	3.00e-90	324.00
IUUC-Pma-094643	Petromyzon marinus	34.47	1.00e-79	289.00
IUUC-Ppa-095354	Physcomitrella patens	37.78	2.00e-86	312.00
IUUC-Pfo-096562	Poecilia formosa	34.55	3.00e-92	331.00
IUUC-Pab-098680	Pongo abelii	38.85	8.00e-90	323.00
IUUC-Pca-100869	Procavia capensis	32.35	3.00e-80	291.00
IUUC-Pva-103040	Pteropus vampyrus	42.35	1.00e-66	246.00
IUUC-Pgr-103315	Puccinia graminis	41.91	2.00e-100	358.00
IUUC-Ptt-103736	Puccinia triticina	42.31	1.00e-100	359.00
IUUC-Rno-105270	Rattus norvegicus	40.62	7.00e-94	336.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.21	8.00e-87	313.00
IUUC-Sha-106819	Sarcophilus harrisii	35.82	1.00e-97	348.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	40.06	7.00e-58	216.00
IUUC-Spo-108271	Schizosaccharomyces pombe	37.18	1.00e-111	395.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	61.14	0.00e+00	751.00
IUUC-Smo-108858	Selaginella moellendorffii	42.31	7.00e-90	323.00
IUUC-Sar-113134	Sorex araneus	36.89	6.00e-79	286.00
IUUC-Ssc-115441	Sus scrofa	40.53	1.00e-93	335.00
IUUC-Tgu-117166	Taeniopygia guttata	34.55	2.00e-87	315.00
IUUC-Tru-118368	Takifugu rubripes	32.31	2.00e-80	291.00
IUUC-Tsy-118898	Tarsius syrichta	37.07	5.00e-70	257.00
IUUC-Tni-120143	Tetraodon nigroviridis	32.48	1.00e-80	292.00
IUUC-Tre-122108	Trichoderma reesei	43.13	0.00e+00	769.00
IUUC-Tvi-122644	Trichoderma virens	42.92	0.00e+00	781.00
IUUC-Tme-127004	Tuber melanosporum	57.31	0.00e+00	716.00
IUUC-Tbe-127640	Tupaia belangeri	37.26	2.00e-63	236.00
IUUC-Ttr-128352	Tursiops truncatus	37.75	8.00e-84	303.00
IUUC-Vda-129969	Verticillium dahliae	58.08	0.00e+00	684.00
IUUC-Vpa-130448	Vicugna pacos	35.33	2.00e-67	249.00
IUUC-Xtr-132881	Xenopus tropicalis	32.51	5.00e-85	307.00
IUUC-Xma-134157	Xiphophorus maculatus	34.70	6.00e-83	300.00
IUUC-Yli-134470	Yarrowia lipolytica	34.76	1.00e-104	372.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence