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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046580
UUCD1 version UUC-HoS-00373
Ensembl Protein ID ENSP00000256649.4
UniProt Accession Q9H8W5; Q53GN0; Q5T2K4; Q5T2K5; Q8IYV6; TRI45_HUMAN
Genbank Protein ID AAT76864.1; BAB14484.1; BAD96621.1; CAI12733.1; CAI12734.1; AAH34943.1
Protein Name Tripartite motif-containing protein 45; RING finger protein 99
Genbank Nucleotide ID AY669488; AK023243; AK222901; AL391476; AL391476; BC034943
Gene Name TRIM45; RNF99
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134253.9 ENST00000497970.5 ENSP00000431261.1
ENSG00000134253.9 ENST00000256649.8 ENSP00000256649.4
ENSG00000134253.9 ENST00000369464.7 ENSP00000358476.3
ENSG00000134253.9 ENST00000369461.3 ENSP00000358473.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.40e-08 34.9 29 98
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.........................pglknssskefrCPlCr 46
           C++Cl  fk  p++lpC H+ +++Cl+++                         + ++ +s+  ++CP+C+
   Q: 29   CPLCLGLFKA-PRLLPCLHTVCTTCLEQLepfsvvdirggdsdtssegsifqelKPRSLQSQIGILCPVCD 98
           ********99.***************999999****************999999777778999999****5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
 May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Protein Sequence
(Fasta)
MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT TCLEQLEPFS 60
VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ VDLPMGGVKA LTIDHLAVND 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046580|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTACACAGG ACTGTGGAAT CCCGGGTGAC ATTCAACTCC TTAGGTCATC TGCACTCCCC 60
CCGGACCGGA AAACAAAGCC TTCCCGAGCC CGACAAGGAG GGTGGCGCTC CCTGGCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046580|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027267--AH/BAR-dom
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0060348--P:bone development
KEGG hsa:80263
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002020 Ailuropoda melanoleuca 91.55 0.00e+00 1028.00
IUUC-Ame-010865 Astyanax mexicanus 47.62 3.00e-131 462.00
IUUC-Bta-012744 Bos taurus 88.97 0.00e+00 1010.00
IUUC-Cel-018225 Caenorhabditis elegans 22.96 5.00e-17 84.00
IUUC-Cja-019162 Callithrix jacchus 93.10 0.00e+00 1043.00
IUUC-Cfa-020163 Canis familiaris 91.38 0.00e+00 1021.00
IUUC-Csa-023746 Chlorocebus sabaeus 96.55 0.00e+00 1087.00
IUUC-Cho-024414 Choloepus hoffmanni 78.69 0.00e+00 758.00
IUUC-Dre-028598 Danio rerio 48.34 4.00e-119 421.00
IUUC-Dno-029616 Dasypus novemcinctus 88.81 0.00e+00 998.00
IUUC-Dor-030216 Dipodomys ordii 82.04 6.00e-69 254.00
IUUC-Dme-031817 Drosophila melanogaster 29.89 8.00e-67 249.00
IUUC-Ete-032434 Echinops telfairi 85.71 0.00e+00 901.00
IUUC-Eca-034410 Equus caballus 90.34 0.00e+00 1012.00
IUUC-Eeu-034954 Erinaceus europaeus 86.57 0.00e+00 977.00
IUUC-Fca-035410 Felis catus 91.55 0.00e+00 1030.00
IUUC-Gmo-039232 Gadus morhua 47.87 3.00e-134 472.00
IUUC-Gac-042350 Gasterosteus aculeatus 45.00 5.00e-107 381.00
IUUC-Ggo-045080 Gorilla gorilla 97.93 0.00e+00 1101.00
IUUC-Itr-048145 Ictidomys tridecemlineatus 88.62 0.00e+00 999.00
IUUC-Lch-049464 Latimeria chalumnae 57.49 0.00e+00 661.00
IUUC-Loc-052772 Lepisosteus oculatus 52.48 8.00e-74 271.00
IUUC-Mcc-055349 Macaca mulatta 94.83 0.00e+00 1060.00
IUUC-Meu-056674 Macropus eugenii 65.86 0.00e+00 742.00
IUUC-Mmr-061225 Microcebus murinus 90.96 0.00e+00 1015.00
IUUC-Mdo-062597 Monodelphis domestica 62.52 0.00e+00 682.00
IUUC-Mmu-063099 Mus musculus 86.03 0.00e+00 972.00
IUUC-Mlu-067034 Myotis lucifugus 88.10 0.00e+00 989.00
IUUC-Nle-069855 Nomascus leucogenys 97.24 0.00e+00 1124.00
IUUC-Opr-070954 Ochotona princeps 89.27 0.00e+00 989.00
IUUC-Ont-071292 Oreochromis niloticus 49.29 6.00e-132 464.00
IUUC-Oga-087909 Otolemur garnettii 87.59 0.00e+00 995.00
IUUC-Oar-089619 Ovis aries 88.97 0.00e+00 1007.00
IUUC-Ptr-090712 Pan troglodytes 98.28 0.00e+00 1108.00
IUUC-Pan-092806 Papio anubis 96.21 0.00e+00 1080.00
IUUC-Psi-093414 Pelodiscus sinensis 64.45 0.00e+00 707.00
IUUC-Pfo-096848 Poecilia formosa 46.96 2.00e-130 459.00
IUUC-Pab-098353 Pongo abelii 95.86 0.00e+00 1080.00
IUUC-Pca-100183 Procavia capensis 87.44 0.00e+00 979.00
IUUC-Pva-102140 Pteropus vampyrus 87.24 0.00e+00 992.00
IUUC-Rno-105886 Rattus norvegicus 86.03 0.00e+00 962.00
IUUC-Sha-107458 Sarcophilus harrisii 64.72 0.00e+00 693.00
IUUC-Sar-112944 Sorex araneus 67.59 0.00e+00 679.00
IUUC-Ssc-116231 Sus scrofa 89.14 0.00e+00 1003.00
IUUC-Tgu-116859 Taeniopygia guttata 56.60 5.00e-158 550.00
IUUC-Tru-118209 Takifugu rubripes 48.93 7.00e-132 464.00
IUUC-Tni-120290 Tetraodon nigroviridis 48.57 5.00e-118 418.00
IUUC-Tbe-128111 Tupaia belangeri 91.00 0.00e+00 886.00
IUUC-Ttr-128584 Tursiops truncatus 87.07 0.00e+00 940.00
IUUC-Vvi-131620 Vitis vinifera 30.00 5.00e-05 40.80
IUUC-Xtr-132137 Xenopus tropicalis 43.28 6.00e-104 371.00
IUUC-Xma-134298 Xiphophorus maculatus 47.96 9.00e-133 467.00
Created Date 25-Jun-2017

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