iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102271.13	ENST00000373119.8	ENSP00000362211.4
ENSG00000102271.13	ENST00000373114.4	ENSP00000362206.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.40e-17	63.3	182	249
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.50e-08	32.1	281	311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+l+ g  +++ah++vL+a S++F a+f+++  e k +++v +++v+p +++ l+++ Ytg l+++e
   Q: 182  CDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAK-QEEVRMEGVDPNALNSLVQYAYTGVLQLKE 249
           8************************************9.**************************9986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi++f+d+ +c++L  +a++++  hF
   Q: 281  PSNCLGIRSFGDAQGCTELLNVAHKYTMEHF 311
           89************************98777 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG RLKSHSRDRN 60
GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF QANEDTPKSV PEKNLFKEAC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGGGGGAG GGGAGAGAAA GCAAGAAAGA CTGCTCTCGG CACTTGTGCT TTTGTTAGTT 60
CTACAGAAGA GGCAGAAAAA CAAGAGATAA CAAAGGCTCC GTTTCCTTTC TGTGAGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0015630--C:microtubule cytoskeleton
GO:0005815--C:microtubule organizing center
GO:0016567--P:protein ubiquitination

KEGG

hsa:56062

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001422	Ailuropoda melanoleuca	90.70	0.00e+00	1289.00
IUUC-Apl-004156	Anas platyrhynchos	86.78	0.00e+00	978.00
IUUC-Aca-004238	Anolis carolinensis	80.00	0.00e+00	1118.00
IUUC-Ame-011287	Astyanax mexicanus	70.48	0.00e+00	908.00
IUUC-Bta-013232	Bos taurus	89.88	0.00e+00	1164.00
IUUC-Cja-018916	Callithrix jacchus	96.67	0.00e+00	1414.00
IUUC-Cfa-020972	Canis familiaris	92.69	0.00e+00	1054.00
IUUC-Csa-023849	Chlorocebus sabaeus	98.43	0.00e+00	1406.00
IUUC-Dor-030708	Dipodomys ordii	84.84	0.00e+00	1210.00
IUUC-Ete-033156	Echinops telfairi	80.81	0.00e+00	814.00
IUUC-Eca-033542	Equus caballus	91.01	0.00e+00	1273.00
IUUC-Fal-036999	Ficedula albicollis	80.91	0.00e+00	1147.00
IUUC-Fox-038050	Fusarium oxysporum	28.89	3.00e-08	52.40
IUUC-Gmo-039532	Gadus morhua	81.08	0.00e+00	894.00
IUUC-Gga-040215	Gallus gallus	82.36	0.00e+00	1182.00
IUUC-Gac-041582	Gasterosteus aculeatus	81.16	0.00e+00	914.00
IUUC-Ggo-045074	Gorilla gorilla	99.43	0.00e+00	1422.00
IUUC-Lch-050265	Latimeria chalumnae	82.39	0.00e+00	951.00
IUUC-Loc-052015	Lepisosteus oculatus	77.67	0.00e+00	1056.00
IUUC-Laf-053627	Loxodonta africana	90.87	0.00e+00	1299.00
IUUC-Mcc-055418	Macaca mulatta	98.57	0.00e+00	1410.00
IUUC-Meu-056859	Macropus eugenii	74.73	1.00e-149	523.00
IUUC-Mga-059582	Meleagris gallopavo	81.95	0.00e+00	1113.00
IUUC-Mmr-061648	Microcebus murinus	93.15	0.00e+00	1333.00
IUUC-Mdo-062785	Monodelphis domestica	85.35	0.00e+00	943.00
IUUC-Mmu-063807	Mus musculus	87.45	0.00e+00	1248.00
IUUC-Mpu-066279	Mustela putorius furo	91.80	0.00e+00	1046.00
IUUC-Mlu-067981	Myotis lucifugus	88.30	0.00e+00	1271.00
IUUC-Nle-070033	Nomascus leucogenys	98.61	0.00e+00	1451.00
IUUC-Ont-071932	Oreochromis niloticus	74.13	0.00e+00	1043.00
IUUC-Ocu-073854	Oryctolagus cuniculus	92.65	0.00e+00	1096.00
IUUC-Ola-087436	Oryzias latipes	72.71	0.00e+00	1010.00
IUUC-Oar-089952	Ovis aries	90.87	0.00e+00	1297.00
IUUC-Ptr-091649	Pan troglodytes	91.73	0.00e+00	1247.00
IUUC-Pan-091798	Papio anubis	98.72	0.00e+00	1411.00
IUUC-Psi-093728	Pelodiscus sinensis	80.80	0.00e+00	1159.00
IUUC-Pfo-096954	Poecilia formosa	73.60	0.00e+00	1027.00
IUUC-Pab-098461	Pongo abelii	98.00	0.00e+00	1396.00
IUUC-Pva-102458	Pteropus vampyrus	91.28	0.00e+00	1191.00
IUUC-Rno-105865	Rattus norvegicus	88.16	0.00e+00	1251.00
IUUC-Sha-107322	Sarcophilus harrisii	84.24	0.00e+00	936.00
IUUC-Ssc-116001	Sus scrofa	93.15	0.00e+00	1342.00
IUUC-Tgu-116994	Taeniopygia guttata	81.91	0.00e+00	1162.00
IUUC-Tru-117780	Takifugu rubripes	68.98	0.00e+00	954.00
IUUC-Tni-120794	Tetraodon nigroviridis	71.61	0.00e+00	964.00
IUUC-Tbe-128118	Tupaia belangeri	75.98	0.00e+00	973.00
IUUC-Ttr-129220	Tursiops truncatus	84.41	0.00e+00	1202.00
IUUC-Vpa-130811	Vicugna pacos	87.08	0.00e+00	1265.00
IUUC-Xtr-132358	Xenopus tropicalis	80.23	0.00e+00	1149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence