iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074123

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02006224

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000015567.1	ENSOCUT00000015566.1	ENSOCUP00000013378.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.60e-16	58.8	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFS HEGASRSDHV DMNSNRCLSV KEKGLGAGEP APQQQSSPLR 60
ENVALQLGLS PAKGSARRSQ NCAAEIPQIV EISIEKENEA CAAAGTRLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAGG TGGGGAAGAT GTGGAATAAC TTCAAATACC GCTGTCAGAA TCTCTTCAGC 60
CATGAGGGAG CGAGCCGCAG TGACCATGTG GACATGAACT CCAACAGGTG TCTGTCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

ocu:100353407

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.20e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	86.38	0.00e+00	954.00
IUUC-Aca-004504	Anolis carolinensis	83.58	0.00e+00	861.00
IUUC-Ame-010677	Astyanax mexicanus	64.10	0.00e+00	631.00
IUUC-Bta-012338	Bos taurus	91.42	0.00e+00	986.00
IUUC-Cja-019828	Callithrix jacchus	90.11	0.00e+00	961.00
IUUC-Cfa-020369	Canis familiaris	90.49	0.00e+00	978.00
IUUC-Cpo-021397	Cavia porcellus	90.11	0.00e+00	992.00
IUUC-Csa-023856	Chlorocebus sabaeus	90.49	0.00e+00	980.00
IUUC-Dre-028262	Danio rerio	64.23	1.00e-169	589.00
IUUC-Dno-029019	Dasypus novemcinctus	91.04	0.00e+00	1002.00
IUUC-Dme-031965	Drosophila melanogaster	67.24	1.00e-69	258.00
IUUC-Eca-033867	Equus caballus	90.11	0.00e+00	992.00
IUUC-Fca-035806	Felis catus	90.67	0.00e+00	978.00
IUUC-Fal-037117	Ficedula albicollis	86.01	0.00e+00	942.00
IUUC-Gmo-039066	Gadus morhua	84.36	3.00e-107	382.00
IUUC-Gga-040876	Gallus gallus	85.63	0.00e+00	929.00
IUUC-Gac-042149	Gasterosteus aculeatus	67.04	0.00e+00	640.00
IUUC-Ggo-045169	Gorilla gorilla	89.37	0.00e+00	974.00
IUUC-Hsa-045805	Homo sapiens	90.49	0.00e+00	981.00
IUUC-Hvu-047122	Hordeum vulgare	41.46	5.00e-03	34.70
IUUC-Itr-049048	Ictidomys tridecemlineatus	90.30	0.00e+00	996.00
IUUC-Lch-049686	Latimeria chalumnae	78.29	0.00e+00	824.00
IUUC-Lpe-051639	Leersia perrieri	35.38	1.00e-02	35.00
IUUC-Loc-051745	Lepisosteus oculatus	72.97	0.00e+00	709.00
IUUC-Laf-054124	Loxodonta africana	89.57	0.00e+00	974.00
IUUC-Mcc-055175	Macaca mulatta	90.49	0.00e+00	980.00
IUUC-Meu-056557	Macropus eugenii	87.20	0.00e+00	964.00
IUUC-Mga-059214	Meleagris gallopavo	85.82	0.00e+00	947.00
IUUC-Mmr-060613	Microcebus murinus	75.75	0.00e+00	764.00
IUUC-Mdo-062788	Monodelphis domestica	86.83	0.00e+00	931.00
IUUC-Mmu-064333	Mus musculus	89.74	0.00e+00	969.00
IUUC-Mpu-066048	Mustela putorius furo	91.04	0.00e+00	984.00
IUUC-Mlu-067430	Myotis lucifugus	90.49	0.00e+00	964.00
IUUC-Nle-069086	Nomascus leucogenys	90.49	0.00e+00	998.00
IUUC-Opr-070312	Ochotona princeps	93.28	0.00e+00	980.00
IUUC-Ont-072299	Oreochromis niloticus	64.95	0.00e+00	630.00
IUUC-Ola-086934	Oryzias latipes	67.71	0.00e+00	651.00
IUUC-Oga-088535	Otolemur garnettii	90.86	0.00e+00	999.00
IUUC-Oar-089875	Ovis aries	91.60	0.00e+00	988.00
IUUC-Ptr-090541	Pan troglodytes	90.49	0.00e+00	981.00
IUUC-Pan-092416	Papio anubis	90.49	0.00e+00	980.00
IUUC-Psi-092960	Pelodiscus sinensis	83.96	0.00e+00	932.00
IUUC-Pma-094222	Petromyzon marinus	49.56	1.00e-132	466.00
IUUC-Pfo-096930	Poecilia formosa	64.26	0.00e+00	654.00
IUUC-Pab-098659	Pongo abelii	90.49	0.00e+00	981.00
IUUC-Pca-100222	Procavia capensis	88.83	0.00e+00	972.00
IUUC-Pva-102387	Pteropus vampyrus	90.11	0.00e+00	975.00
IUUC-Rno-105698	Rattus norvegicus	90.11	0.00e+00	977.00
IUUC-Sha-107234	Sarcophilus harrisii	85.90	0.00e+00	927.00
IUUC-Sar-113698	Sorex araneus	87.87	0.00e+00	883.00
IUUC-Ssc-115985	Sus scrofa	90.86	0.00e+00	1001.00
IUUC-Tgu-116676	Taeniopygia guttata	86.19	0.00e+00	948.00
IUUC-Tru-118441	Takifugu rubripes	59.74	3.00e-149	521.00
IUUC-Tsy-119163	Tarsius syrichta	87.13	0.00e+00	949.00
IUUC-Tni-120436	Tetraodon nigroviridis	67.90	0.00e+00	645.00
IUUC-Tae-124846	Triticum aestivum	36.73	2.50e-02	32.00
IUUC-Tbe-127353	Tupaia belangeri	90.11	0.00e+00	978.00
IUUC-Ttr-128907	Tursiops truncatus	91.04	0.00e+00	971.00
IUUC-Vpa-130140	Vicugna pacos	91.04	0.00e+00	986.00
IUUC-Xtr-132817	Xenopus tropicalis	77.65	0.00e+00	847.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence