iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
HINT	Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-14	54.5	101	156

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 101  FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 156
           789***********************..8999**********************9875 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MLDLIMGCIK SKENKSPAIK YRPENTPEPV STSVSHYGAE PTTVSPCPSS SAKGTAVNFS 60
SLSMTPFGGS SGVTPFGGAS SSFSVVPSSY PAGLTGGVTI FVALYDYEAR TTEDLSFKKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCGGGAGA AGTGACACGG ACCGGTCGCC TATCCTGACC ACAGCAAAGC GGCCCGGAGC 60
CCGCGGAGGG GACCTGACGG GGGCGTAGGC GCCGGAAGGC TGGGGGCCCC GGAGCCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	97.43	0.00e+00	1060.00
IUUC-Apl-004032	Anas platyrhynchos	92.27	0.00e+00	1014.00
IUUC-Aca-004255	Anolis carolinensis	90.98	0.00e+00	1023.00
IUUC-Ame-010954	Astyanax mexicanus	85.74	0.00e+00	976.00
IUUC-Bta-013503	Bos taurus	96.87	0.00e+00	1030.00
IUUC-Cja-019694	Callithrix jacchus	98.34	0.00e+00	1047.00
IUUC-Cfa-020402	Canis familiaris	97.61	0.00e+00	1062.00
IUUC-Cpo-022506	Cavia porcellus	96.32	0.00e+00	1048.00
IUUC-Csa-023713	Chlorocebus sabaeus	99.63	0.00e+00	1062.00
IUUC-Csv-026029	Ciona savignyi	63.81	0.00e+00	632.00
IUUC-Dre-027978	Danio rerio	84.62	0.00e+00	938.00
IUUC-Dno-029897	Dasypus novemcinctus	96.05	0.00e+00	934.00
IUUC-Dor-030202	Dipodomys ordii	97.79	0.00e+00	929.00
IUUC-Eca-034157	Equus caballus	97.97	0.00e+00	1065.00
IUUC-Eeu-034950	Erinaceus europaeus	91.81	1.00e-178	619.00
IUUC-Fca-036233	Felis catus	97.24	0.00e+00	1080.00
IUUC-Fal-037461	Ficedula albicollis	92.27	0.00e+00	1035.00
IUUC-Gmo-038929	Gadus morhua	82.70	0.00e+00	911.00
IUUC-Gga-041107	Gallus gallus	91.90	0.00e+00	1015.00
IUUC-Gac-042321	Gasterosteus aculeatus	83.79	0.00e+00	944.00
IUUC-Ggo-044597	Gorilla gorilla	79.12	0.00e+00	832.00
IUUC-Lch-050239	Latimeria chalumnae	89.50	0.00e+00	1011.00
IUUC-Lpe-051166	Leersia perrieri	35.47	5.00e-23	103.00
IUUC-Loc-052314	Lepisosteus oculatus	87.75	0.00e+00	944.00
IUUC-Laf-053517	Loxodonta africana	97.05	0.00e+00	1035.00
IUUC-Mcc-055626	Macaca mulatta	99.45	0.00e+00	1065.00
IUUC-Mga-059310	Meleagris gallopavo	91.90	0.00e+00	1015.00
IUUC-Mmr-061652	Microcebus murinus	97.05	0.00e+00	1058.00
IUUC-Mdo-062963	Monodelphis domestica	91.90	0.00e+00	1026.00
IUUC-Mmu-064128	Mus musculus	95.95	0.00e+00	1065.00
IUUC-Mpu-065906	Mustela putorius furo	97.79	0.00e+00	1065.00
IUUC-Mlu-067035	Myotis lucifugus	97.07	0.00e+00	1055.00
IUUC-Nle-069041	Nomascus leucogenys	95.58	0.00e+00	1031.00
IUUC-Opr-070299	Ochotona princeps	86.92	0.00e+00	924.00
IUUC-Ont-072337	Oreochromis niloticus	85.19	0.00e+00	963.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.36	0.00e+00	932.00
IUUC-Ocu-074171	Oryctolagus cuniculus	97.05	0.00e+00	1061.00
IUUC-Ogl-077331	Oryza glaberrima	35.47	3.00e-23	103.00
IUUC-Ola-086619	Oryzias latipes	84.39	0.00e+00	961.00
IUUC-Oga-087957	Otolemur garnettii	96.50	0.00e+00	1043.00
IUUC-Oar-089670	Ovis aries	95.76	0.00e+00	1026.00
IUUC-Ptr-091352	Pan troglodytes	100.00	0.00e+00	1091.00
IUUC-Pan-092202	Papio anubis	99.45	0.00e+00	1065.00
IUUC-Psi-093310	Pelodiscus sinensis	90.69	0.00e+00	1025.00
IUUC-Pma-094232	Petromyzon marinus	87.69	0.00e+00	861.00
IUUC-Pfo-096137	Poecilia formosa	83.54	0.00e+00	936.00
IUUC-Pab-098301	Pongo abelii	99.79	0.00e+00	971.00
IUUC-Pva-102592	Pteropus vampyrus	92.82	0.00e+00	997.00
IUUC-Rno-105544	Rattus norvegicus	95.58	0.00e+00	1029.00
IUUC-Sar-113364	Sorex araneus	93.00	0.00e+00	978.00
IUUC-Tgu-117380	Taeniopygia guttata	92.27	0.00e+00	1035.00
IUUC-Tru-117594	Takifugu rubripes	84.57	0.00e+00	947.00
IUUC-Tni-120433	Tetraodon nigroviridis	84.63	0.00e+00	941.00
IUUC-Ttr-128893	Tursiops truncatus	97.42	0.00e+00	1063.00
IUUC-Vpa-130060	Vicugna pacos	97.79	0.00e+00	1052.00
IUUC-Xtr-132322	Xenopus tropicalis	90.06	0.00e+00	1006.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence