iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044704

UUCD1 version

UUC-GoG-00917

Ensembl Protein ID

ENSGGOP00000025662.1

UniProt Accession

G3SC35; G3SC35_GORGO

Protein Name

Uncharacterized protein

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000009724.2	ENSGGOT00000009781.2	ENSGGOP00000009515.2
ENSGGOG00000009724.2	ENSGGOT00000027832.1	ENSGGOP00000025662.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	1.50e-40	137.6	199	275
E3 activity/RING/RING	1.90e-08	35.1	1069	1172
E3 activity/N-recognin/UBR-box	2.30e-31	108.5	70	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 199  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEV 275
           9**************************************************************************97 PP

E3 activity/RING/RING

   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw............. 29
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             
   Q: 1069 CILCQEEQevkiennamvlsacvQKstaltqhrgkpielsgealdplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqrih 1155
           88885554433333333333222002333333333333333333333333333337999**************************** PP
   S: 30   pglknssskefrCPlCr 46
           ++l +++s+e +CPlC+
   Q: 1156 VDLFDLESGEYLCPLCK 1172
           ****************7 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 70   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHE 140
           68*******************************************************************96 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

WWDQQVDFYT AFLHHLAQLV PEIYFAEMDP DLEKQEESVQ MSIFTPLEWY LFGEDPDICL 60
EKLKHSGAFQ LCGKVFKSGE TTYSCRDCAI DPTCVLCMDC FQNSVHKNHR YKMHTSTGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG AGGAGGCTGG AGGTACTGAG AGGGTGGAAA TCAGCGCGGA GTTACCCCAG 60
ACCCCTCAGC GTCTGACATC TGTAAGTCCC TATAGGCAAG TCTCTTTTGT CCTCCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	87.51	0.00e+00	2568.00
IUUC-Apl-004160	Anas platyrhynchos	72.39	0.00e+00	2119.00
IUUC-Aca-004982	Anolis carolinensis	69.67	0.00e+00	2042.00
IUUC-Acl-008055	Aspergillus clavatus	24.53	1.00e-35	146.00
IUUC-Ani-009334	Aspergillus nidulans	23.81	2.00e-37	152.00
IUUC-Ame-011231	Astyanax mexicanus	53.12	0.00e+00	1446.00
IUUC-Bta-012347	Bos taurus	87.10	0.00e+00	2568.00
IUUC-Cja-018911	Callithrix jacchus	85.73	0.00e+00	2489.00
IUUC-Cfa-020991	Canis familiaris	88.50	0.00e+00	2598.00
IUUC-Cpo-021448	Cavia porcellus	85.15	0.00e+00	2533.00
IUUC-Csa-024255	Chlorocebus sabaeus	90.93	0.00e+00	2538.00
IUUC-Cho-024550	Choloepus hoffmanni	67.99	0.00e+00	1905.00
IUUC-Csv-026033	Ciona savignyi	36.49	7.00e-12	62.80
IUUC-Dno-029427	Dasypus novemcinctus	86.58	0.00e+00	2499.00
IUUC-Dor-031073	Dipodomys ordii	71.28	0.00e+00	1195.00
IUUC-Ete-032318	Echinops telfairi	79.13	0.00e+00	758.00
IUUC-Eca-033348	Equus caballus	86.97	0.00e+00	2363.00
IUUC-Eeu-034664	Erinaceus europaeus	79.83	0.00e+00	2343.00
IUUC-Fca-035604	Felis catus	81.45	0.00e+00	2311.00
IUUC-Fal-037333	Ficedula albicollis	72.11	0.00e+00	2081.00
IUUC-Gga-040486	Gallus gallus	72.00	0.00e+00	2110.00
IUUC-Gac-041985	Gasterosteus aculeatus	52.11	0.00e+00	1306.00
IUUC-Hsa-046753	Homo sapiens	92.18	0.00e+00	2697.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	88.70	0.00e+00	2589.00
IUUC-Lch-049904	Latimeria chalumnae	57.39	0.00e+00	1617.00
IUUC-Loc-052624	Lepisosteus oculatus	56.05	0.00e+00	1582.00
IUUC-Lma-053059	Leptosphaeria maculans	23.81	8.00e-33	137.00
IUUC-Laf-053857	Loxodonta africana	84.16	0.00e+00	2481.00
IUUC-Mcc-054873	Macaca mulatta	90.99	0.00e+00	2620.00
IUUC-Meu-056858	Macropus eugenii	82.97	0.00e+00	629.00
IUUC-Mga-059917	Meleagris gallopavo	71.87	0.00e+00	2132.00
IUUC-Mmr-061128	Microcebus murinus	86.98	0.00e+00	2511.00
IUUC-Mdo-062306	Monodelphis domestica	75.24	0.00e+00	2214.00
IUUC-Mmu-063389	Mus musculus	85.86	0.00e+00	2542.00
IUUC-Mpu-065983	Mustela putorius furo	87.97	0.00e+00	2610.00
IUUC-Mlu-068013	Myotis lucifugus	84.74	0.00e+00	2496.00
IUUC-Nle-070031	Nomascus leucogenys	91.65	0.00e+00	2681.00
IUUC-Opr-070551	Ochotona princeps	83.30	0.00e+00	665.00
IUUC-Ont-072035	Oreochromis niloticus	53.70	0.00e+00	1545.00
IUUC-Ocu-074930	Oryctolagus cuniculus	84.10	0.00e+00	2433.00
IUUC-Oin-079343	Oryza indica	36.76	3.00e-13	72.00
IUUC-Osa-086106	Oryza sativa	36.76	2.00e-13	71.20
IUUC-Ola-086683	Oryzias latipes	53.42	0.00e+00	1490.00
IUUC-Oga-088017	Otolemur garnettii	86.87	0.00e+00	2471.00
IUUC-Oar-089557	Ovis aries	86.69	0.00e+00	2566.00
IUUC-Ptr-091366	Pan troglodytes	90.79	0.00e+00	2671.00
IUUC-Pan-092184	Papio anubis	90.79	0.00e+00	2619.00
IUUC-Psi-093720	Pelodiscus sinensis	73.46	0.00e+00	2091.00
IUUC-Pfo-097124	Poecilia formosa	53.55	0.00e+00	1511.00
IUUC-Pab-098586	Pongo abelii	91.58	0.00e+00	2679.00
IUUC-Pop-099184	Populus trichocarpa	44.21	1.00e-13	70.90
IUUC-Pca-100673	Procavia capensis	76.05	0.00e+00	1459.00
IUUC-Pva-102724	Pteropus vampyrus	80.70	0.00e+00	2326.00
IUUC-Pte-104174	Pyrenophora teres	23.85	2.00e-34	142.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.54	4.00e-33	138.00
IUUC-Rno-105474	Rattus norvegicus	79.34	0.00e+00	1642.00
IUUC-Sha-106993	Sarcophilus harrisii	76.15	0.00e+00	2285.00
IUUC-Ssl-108638	Sclerotinia sclerotiorum	25.64	5.70e-02	32.00
IUUC-Sar-113447	Sorex araneus	80.50	0.00e+00	1881.00
IUUC-Ssc-115768	Sus scrofa	82.25	0.00e+00	2233.00
IUUC-Tgu-116949	Taeniopygia guttata	67.37	0.00e+00	1897.00
IUUC-Tsy-119177	Tarsius syrichta	87.93	0.00e+00	1537.00
IUUC-Tni-120884	Tetraodon nigroviridis	50.20	0.00e+00	1347.00
IUUC-Tbe-128088	Tupaia belangeri	84.99	0.00e+00	907.00
IUUC-Ttr-129062	Tursiops truncatus	82.35	0.00e+00	2414.00
IUUC-Vpa-130578	Vicugna pacos	80.03	0.00e+00	2305.00
IUUC-Xtr-132244	Xenopus tropicalis	56.24	0.00e+00	1585.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence