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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047001
UUCD1 version UUC-HoS-00434
Ensembl Protein ID ENSP00000344866.3
UniProt Accession Q9UKA1; A8MSK4; B4DIB5; Q4W5A8; Q8NHP3; Q9NXN2; Q9P0I0; Q9P0X5; Q9UJT7; Q9UKC8; FBXL5_HUMAN
Genbank Protein ID AAF03700.1; AAF09249.1; AAF66616.1; BAA90978.1; BAG58427.1; CAD97924.1; AAY40929.1; EAW92737.1; EAW92739.1; AAH30656.1; AAF67489.1; AAF04512.1
Protein Name F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein
Genbank Nucleotide ID AF176700; AF199420; AF142481; AK000153; AK295510; BX537957; AC114744; AC116651; CH471069; BC030656; AF157323; AF174591
Gene Name FBXL5; FBL4; FBL5; FLR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000118564.14 ENST00000341285.7 ENSP00000344866.3
ENSG00000118564.14 ENST00000513163.5 ENSP00000425472.1
ENSG00000118564.14 ENST00000511441.5 ENSP00000425027.1
ENSG00000118564.14 ENST00000412094.6 ENSP00000408679.2
ENSG00000118564.14 ENST00000512066.5 ENSP00000426993.1
ENSG00000118564.14 ENST00000507899.1 ENSP00000422049.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMIC
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19762596; 17532294
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 8.50e-05 24.3 202 248
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++ +++lp e++++i+++l+++el+r+++v+ +w++l+++ +lwk++
   Q: 202  STGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 248
           556789*********************************9****987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
Protein Sequence
(Fasta)
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI 60
ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047001|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTTTTCCAC TTCCCTACGC TCTGTCGGCA GTCTCGCGGG ATTTCCGCCT CTCGCGGGAG 60
TTATTTGAAT GCCAGGGCGG TAACGACTCC CTAGGCGCCT GGGGCCCTCT GACAAGAAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047001|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR012312--Haemerythrin-like
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF01814--Hemerythrin
PF13516--LRR_6
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0005506--F:iron ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0055072--P:iron ion homeostasis
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:26234
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002319 Ailuropoda melanoleuca 95.96 0.00e+00 1210.00
IUUC-Apl-003755 Anas platyrhynchos 79.67 0.00e+00 1004.00
IUUC-Aca-004798 Anolis carolinensis 76.91 0.00e+00 1043.00
IUUC-Ame-011091 Astyanax mexicanus 60.14 0.00e+00 761.00
IUUC-Bta-013204 Bos taurus 93.86 0.00e+00 1213.00
IUUC-Cja-019594 Callithrix jacchus 96.81 0.00e+00 1070.00
IUUC-Cfa-020965 Canis familiaris 96.24 0.00e+00 1255.00
IUUC-Cpo-021308 Cavia porcellus 93.63 0.00e+00 1260.00
IUUC-Csa-023865 Chlorocebus sabaeus 98.55 0.00e+00 1350.00
IUUC-Cho-024778 Choloepus hoffmanni 82.37 1.00e-162 566.00
IUUC-Dre-027628 Danio rerio 54.80 2.00e-177 615.00
IUUC-Dno-029899 Dasypus novemcinctus 94.17 0.00e+00 1298.00
IUUC-Dor-031105 Dipodomys ordii 81.90 0.00e+00 1078.00
IUUC-Ete-032314 Echinops telfairi 86.88 0.00e+00 1092.00
IUUC-Eca-033797 Equus caballus 94.81 0.00e+00 1153.00
IUUC-Eeu-034811 Erinaceus europaeus 84.15 0.00e+00 894.00
IUUC-Fca-036516 Felis catus 95.48 0.00e+00 1190.00
IUUC-Fal-036824 Ficedula albicollis 77.55 0.00e+00 939.00
IUUC-Gga-040271 Gallus gallus 80.49 0.00e+00 1075.00
IUUC-Gac-041399 Gasterosteus aculeatus 61.85 0.00e+00 792.00
IUUC-Ggo-044415 Gorilla gorilla 99.42 0.00e+00 1357.00
IUUC-Itr-048356 Ictidomys tridecemlineatus 94.09 0.00e+00 1064.00
IUUC-Lch-049897 Latimeria chalumnae 65.76 0.00e+00 833.00
IUUC-Loc-052162 Lepisosteus oculatus 66.15 0.00e+00 862.00
IUUC-Laf-054031 Loxodonta africana 95.37 0.00e+00 1278.00
IUUC-Mcc-054680 Macaca mulatta 98.55 0.00e+00 1350.00
IUUC-Meu-056199 Macropus eugenii 85.02 3.00e-108 386.00
IUUC-Mga-059675 Meleagris gallopavo 79.85 0.00e+00 1025.00
IUUC-Mmr-061694 Microcebus murinus 96.82 0.00e+00 1334.00
IUUC-Mdo-062900 Monodelphis domestica 90.01 0.00e+00 1233.00
IUUC-Mmu-063178 Mus musculus 93.63 0.00e+00 1284.00
IUUC-Mpu-066584 Mustela putorius furo 95.66 0.00e+00 1260.00
IUUC-Mlu-067859 Myotis lucifugus 94.58 0.00e+00 1202.00
IUUC-Nle-069172 Nomascus leucogenys 99.13 0.00e+00 1328.00
IUUC-Opr-070992 Ochotona princeps 90.63 0.00e+00 1025.00
IUUC-Ont-072577 Oreochromis niloticus 61.42 0.00e+00 790.00
IUUC-Oan-072870 Ornithorhynchus anatinus 84.70 0.00e+00 915.00
IUUC-Ocu-074849 Oryctolagus cuniculus 92.76 0.00e+00 1262.00
IUUC-Ola-087146 Oryzias latipes 60.56 0.00e+00 778.00
IUUC-Oga-088307 Otolemur garnettii 95.36 0.00e+00 1257.00
IUUC-Oar-090192 Ovis aries 91.91 0.00e+00 1224.00
IUUC-Ptr-091049 Pan troglodytes 99.71 0.00e+00 1361.00
IUUC-Pan-091995 Papio anubis 98.70 0.00e+00 1353.00
IUUC-Psi-093154 Pelodiscus sinensis 79.75 0.00e+00 996.00
IUUC-Pma-094334 Petromyzon marinus 46.44 1.00e-138 486.00
IUUC-Pfo-096154 Poecilia formosa 60.72 0.00e+00 768.00
IUUC-Pab-098264 Pongo abelii 99.10 0.00e+00 1296.00
IUUC-Pca-100884 Procavia capensis 73.08 0.00e+00 947.00
IUUC-Pva-102114 Pteropus vampyrus 94.80 0.00e+00 1296.00
IUUC-Rno-105392 Rattus norvegicus 93.92 0.00e+00 1285.00
IUUC-Sha-106508 Sarcophilus harrisii 86.94 0.00e+00 1172.00
IUUC-Sar-113107 Sorex araneus 90.73 0.00e+00 844.00
IUUC-Ssc-115489 Sus scrofa 96.09 0.00e+00 1254.00
IUUC-Tgu-116734 Taeniopygia guttata 78.48 0.00e+00 1024.00
IUUC-Tru-117632 Takifugu rubripes 61.24 0.00e+00 778.00
IUUC-Tsy-119400 Tarsius syrichta 95.48 0.00e+00 1224.00
IUUC-Tni-120602 Tetraodon nigroviridis 60.06 0.00e+00 787.00
IUUC-Tbe-127833 Tupaia belangeri 94.19 0.00e+00 666.00
IUUC-Ttr-129289 Tursiops truncatus 95.17 0.00e+00 765.00
IUUC-Vpa-130253 Vicugna pacos 95.30 0.00e+00 635.00
Created Date 25-Jun-2017

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